Abstract
Background: Claudins are tight junction proteins and their expression is often different in normal and corresponding tumor cells. In the present study, we determined how the expression of claudins 1-5 and 7 correlated to survival, grade and stage of patients with renal cell cancer (RCC). Patients and Methods: Primary tumor samples were collected retrospectively from 229 RCC patients. Claudins were detected by immunohistochemistry using commercial monoclonal antibodies against claudins 1-5 and 7. Median survival time was 6.5 years confidence interval (CI) (4.5-8.5, n=224). Kaplan-Meier survival estimated method was used in survival analyses. Results: Positive expression was detected in 62%, 67%, 45%, 55%, 7% and 35% of cases for claudins 1, 2, 3, 4, 5 and 7, respectively. High expression of claudin 2 was observed in 20% of cases while high expression of other claudins was less frequent. Claudins were compared to classical prognostic factors. On cross-tabulation, claudin 1 (p
| Original language | English |
|---|---|
| Pages (from-to) | 4181-4188 |
| Number of pages | 8 |
| Journal | Anticancer Research |
| Volume | 34 |
| Issue number | 8 |
| Publication status | Published - 2014 |
| Publication type | A1 Journal article-refereed |
Keywords
- Claudins
- Expression
- Prognostic factors
- Renal cell cancer (RCC)
Publication forum classification
- Publication forum level 1
