Coagulopathy in acute Puumala hantavirus infection

Sirpa Koskela, Satu Mäkelä, Tomas Strandin, Antti Vaheri, Tuula Outinen, Lotta Joutsi-Korhonen, Ilkka Pörsti, Jukka Mustonen, Outi Laine

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Abstract

Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein–kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis.

Original languageEnglish
Article number1553
JournalViruses
Volume13
Issue number8
DOIs
Publication statusPublished - Aug 2021
Publication typeA2 Review article in a scientific journal

Keywords

  • Acute kidney injury
  • Coagulation
  • Complement system
  • DIC
  • Endothelium
  • Fibrinolysis
  • Platelet
  • Puumala hantavirus

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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