Coagulopathy in acute Puumala hantavirus infection

Sirpa Koskela, Satu Mäkelä, Tomas Strandin, Antti Vaheri, Tuula Outinen, Lotta Joutsi-Korhonen, Ilkka Pörsti, Jukka Mustonen, Outi Laine

Research output: Contribution to journalReview Articlepeer-review

3 Downloads (Pure)


Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein–kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis.

Original languageEnglish
Article number1553
Issue number8
Publication statusPublished - Aug 2021
Publication typeA2 Review article in a scientific journal


  • Acute kidney injury
  • Coagulation
  • Complement system
  • DIC
  • Endothelium
  • Fibrinolysis
  • Platelet
  • Puumala hantavirus

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


Dive into the research topics of 'Coagulopathy in acute Puumala hantavirus infection'. Together they form a unique fingerprint.

Cite this