Coagulopathy in acute Puumala hantavirus infection

Sirpa Koskela; Satu Mäkelä; Tomas Strandin; Antti Vaheri; Tuula Outinen; Lotta Joutsi-Korhonen; Ilkka Pörsti; Jukka Mustonen; Outi Laine

doi:10.3390/v13081553

Coagulopathy in acute Puumala hantavirus infection

Sirpa Koskela, Satu Mäkelä, Tomas Strandin, Antti Vaheri, Tuula Outinen, Lotta Joutsi-Korhonen, Ilkka Pörsti, Jukka Mustonen, Outi Laine

Research output: Contribution to journal › Review Article › peer-review

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Abstract

Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein–kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis.

Original language	English
Article number	1553
Journal	Viruses
Volume	13
Issue number	8
DOIs	https://doi.org/10.3390/v13081553
Publication status	Published - Aug 2021
Publication type	A2 Review article in a scientific journal

Keywords

Acute kidney injury
Coagulation
Complement system
DIC
Endothelium
Fibrinolysis
Platelet
Puumala hantavirus

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Infectious Diseases
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/v13081553Licence: CC BY

viruses-13-01553Final published version, 557 KBLicence: CC BY

http://urn.fi/URN:NBN:fi:tuni-202108306867Licence: CC BY

Cite this

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title = "Coagulopathy in acute Puumala hantavirus infection",

abstract = "Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein–kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis.",

keywords = "Acute kidney injury, Coagulation, Complement system, DIC, Endothelium, Fibrinolysis, Platelet, Puumala hantavirus",

author = "Sirpa Koskela and Satu M{\"a}kel{\"a} and Tomas Strandin and Antti Vaheri and Tuula Outinen and Lotta Joutsi-Korhonen and Ilkka P{\"o}rsti and Jukka Mustonen and Outi Laine",

note = "Funding Information: Funding: The research of the authors has been supported by Sigrid Juselius Foundation, The Competitive State Research Funding of the Expert Responsibility Area of Tampere University Hospital, and The Finnish Kidney Foundation. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).",

year = "2021",

month = aug,

doi = "10.3390/v13081553",

language = "English",

volume = "13",

number = "8",

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TY - JOUR

T1 - Coagulopathy in acute Puumala hantavirus infection

AU - Koskela, Sirpa

AU - Mäkelä, Satu

AU - Strandin, Tomas

AU - Vaheri, Antti

AU - Outinen, Tuula

AU - Joutsi-Korhonen, Lotta

AU - Pörsti, Ilkka

AU - Mustonen, Jukka

AU - Laine, Outi

N1 - Funding Information: Funding: The research of the authors has been supported by Sigrid Juselius Foundation, The Competitive State Research Funding of the Expert Responsibility Area of Tampere University Hospital, and The Finnish Kidney Foundation. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

PY - 2021/8

Y1 - 2021/8

N2 - Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein–kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis.

AB - Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein–kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis.

KW - Acute kidney injury

KW - Coagulation

KW - Complement system

KW - DIC

KW - Endothelium

KW - Fibrinolysis

KW - Platelet

KW - Puumala hantavirus

U2 - 10.3390/v13081553

DO - 10.3390/v13081553

M3 - Review Article

C2 - 34452419

AN - SCOPUS:85112230228

VL - 13

IS - 8

M1 - 1553

ER -

Coagulopathy in acute Puumala hantavirus infection

Abstract

Keywords

Publication forum classification

ASJC Scopus subject areas

UN SDGs

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