Coeliac disease: what can we learn from prospective studies about disease risk?

Marisa Stahl, Sibylle Koletzko, Carin Andrén Aronsson, Katri Lindfors, Edwin Liu, Daniel Agardh, TEDDY Study Group

    Research output: Contribution to journalReview Articlepeer-review

    32 Downloads (Pure)

    Abstract

    Paediatric prospective studies of coeliac disease with longitudinal collection of biological samples and clinical data offer a unique perspective on disease risk. This Review highlights the information now available from international paediatric prospective studies on genetic and environmental risk factors for coeliac disease. In addition, recent omics studies have made it possible to study complex interactions between genetic and environmental factors and thereby further our insight into the causes of the disease. In the future, paediatric prospective studies will be able to provide more detailed risk prediction models combining genes, the environment, and biological corroboration from multiomics. Such studies could also contribute to biomarker development and an improved understanding of disease pathogenesis.

    Original languageEnglish
    Pages (from-to)63-74
    Number of pages12
    JournalThe Lancet. Child and adolescent health
    Volume8
    Issue number1
    Early online date13 Nov 2023
    DOIs
    Publication statusPublished - 2024
    Publication typeA2 Review article in a scientific journal

    Publication forum classification

    • Publication forum level 3

    Fingerprint

    Dive into the research topics of 'Coeliac disease: what can we learn from prospective studies about disease risk?'. Together they form a unique fingerprint.

    Cite this