Common features of chromatin in aging and cancer: Cause or coincidence?

Linda Zane; Vivek Sharma; Tom Misteli

doi:10.1016/j.tcb.2014.07.001

Common features of chromatin in aging and cancer: Cause or coincidence?

Linda Zane, Vivek Sharma, Tom Misteli

Research output: Contribution to journal › Review Article › peer-review

38 Citations (Scopus)

Abstract

Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly - or possibly coincidentally - several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis.

Original language	English
Pages (from-to)	686-694
Number of pages	9
Journal	TRENDS IN CELL BIOLOGY
Volume	24
Issue number	11
DOIs	https://doi.org/10.1016/j.tcb.2014.07.001
Publication status	Published - 2014
Publication type	A2 Review article in a scientific journal

ASJC Scopus subject areas

Cell Biology
Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tcb.2014.07.001

Cite this

@article{e03d900e1f6e46cba26ddf26bafe8f7e,

title = "Common features of chromatin in aging and cancer: Cause or coincidence?",

abstract = "Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly - or possibly coincidentally - several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis.",

author = "Linda Zane and Vivek Sharma and Tom Misteli",

year = "2014",

doi = "10.1016/j.tcb.2014.07.001",

language = "English",

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pages = "686--694",

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TY - JOUR

T1 - Common features of chromatin in aging and cancer

T2 - Cause or coincidence?

AU - Zane, Linda

AU - Sharma, Vivek

AU - Misteli, Tom

PY - 2014

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N2 - Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly - or possibly coincidentally - several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis.

AB - Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly - or possibly coincidentally - several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis.

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U2 - 10.1016/j.tcb.2014.07.001

DO - 10.1016/j.tcb.2014.07.001

M3 - Review Article

C2 - 25103681

AN - SCOPUS:84927698872

SN - 0962-8924

VL - 24

SP - 686

EP - 694

JO - TRENDS IN CELL BIOLOGY

JF - TRENDS IN CELL BIOLOGY

IS - 11

ER -

Common features of chromatin in aging and cancer: Cause or coincidence?

Abstract

ASJC Scopus subject areas

UN SDGs

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