Common features of chromatin in aging and cancer: Cause or coincidence?

Linda Zane, Vivek Sharma, Tom Misteli

    Research output: Contribution to journalReview Articlepeer-review

    55 Citations (Scopus)

    Abstract

    Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly - or possibly coincidentally - several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis.

    Original languageEnglish
    Pages (from-to)686-694
    Number of pages9
    JournalTRENDS IN CELL BIOLOGY
    Volume24
    Issue number11
    DOIs
    Publication statusPublished - 2014
    Publication typeA2 Review article in a scientific journal

    ASJC Scopus subject areas

    • Cell Biology
    • General Medicine

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