Common features of chromatin in aging and cancer: Cause or coincidence?

Linda Zane; Vivek Sharma; Tom Misteli

doi:10.1016/j.tcb.2014.07.001

Common features of chromatin in aging and cancer: Cause or coincidence?

Linda Zane
, Vivek Sharma
, Tom Misteli^*

^*Corresponding author for this work

Research output: Contribution to journal › Review Article › peer-review

61 Citations (Scopus)

Abstract

Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly - or possibly coincidentally - several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis.

Original language	English
Pages (from-to)	686-694
Number of pages	9
Journal	Trends in Cell Biology
Volume	24
Issue number	11
DOIs	https://doi.org/10.1016/j.tcb.2014.07.001
Publication status	Published - 2014
Publication type	A2 Review article in a scientific journal

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Cell Biology
General Medicine

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10.1016/j.tcb.2014.07.001

Cite this

@article{e03d900e1f6e46cba26ddf26bafe8f7e,

title = "Common features of chromatin in aging and cancer: Cause or coincidence?",

abstract = "Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly - or possibly coincidentally - several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis.",

author = "Linda Zane and Vivek Sharma and Tom Misteli",

year = "2014",

doi = "10.1016/j.tcb.2014.07.001",

language = "English",

volume = "24",

pages = "686--694",

journal = "Trends in Cell Biology",

issn = "0962-8924",

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number = "11",

}

TY - JOUR

T1 - Common features of chromatin in aging and cancer

T2 - Cause or coincidence?

AU - Zane, Linda

AU - Sharma, Vivek

AU - Misteli, Tom

PY - 2014

Y1 - 2014

N2 - Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly - or possibly coincidentally - several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis.

AB - Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly - or possibly coincidentally - several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis.

UR - https://www.scopus.com/pages/publications/84927698872

U2 - 10.1016/j.tcb.2014.07.001

DO - 10.1016/j.tcb.2014.07.001

M3 - Review Article

C2 - 25103681

AN - SCOPUS:84927698872

SN - 0962-8924

VL - 24

SP - 686

EP - 694

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 11

ER -

Common features of chromatin in aging and cancer: Cause or coincidence?

Abstract

UN SDGs

ASJC Scopus subject areas

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