Comparison of linear and non-linear heart rate variability indices between preterm infants at their theoretical term age and full term newborns

E. Helander, N. Khodor, A. Kallonen, A. Värri, H. Patural, G. Carrault, P. Pladys

    Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

    Abstract

    Heart rate variability (HRV) enables non-invasive evaluation of cardiac autonomic activity. Preterm infants are known to have altered HRV characteristics that remain even when reaching their term age. Little is known about non-linear HRV measures between full term and preterm babies close to their theoretical full term. In this study, we calculated sample entropy, shape-describing parameters (skewness and kurtosis) and detrended fluctuation analysis coefficients α1 and α2 from RR time series of 16 very preterm babies (37 weeks, “FT group”) infants. Compared to the FT group, smaller values of sample entropy and lower values of α1 were found in the PT group. No difference in α2, kurtosis, or skewness was found. This indicates decrease in overall complexity of HR dynamics in the PT group. When various HRV indices, that included also non-linear indices, were projected to the principal component analysis space obtained from the FT group, a good separation between the PT and FT groups was found. The study was limited by a small sample but the results were in line with literature. The combinations of several HRV parameters can be of interest for future studies on the degree of ANS maturity.

    Original languageEnglish
    Title of host publicationEMBEC and NBC 2017 - Joint Conference of the European Medical and Biological Engineering Conference EMBEC 2017 and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2017
    PublisherSpringer Verlag
    Pages153-156
    Number of pages4
    ISBN (Print)9789811051210
    DOIs
    Publication statusPublished - 2018
    Publication typeA4 Article in conference proceedings
    EventJoint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC) -
    Duration: 1 Jan 1900 → …

    Publication series

    NameIFMBE Proceedings
    Volume65
    ISSN (Print)1680-0737

    Conference

    ConferenceJoint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC)
    Period1/01/00 → …

    Keywords

    • Autonomic nervous system
    • Detrended fluctuation analysis
    • Heart rate variability
    • Premature infant
    • Sample entropy

    Publication forum classification

    • Publication forum level 1

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Bioengineering

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