Comprehensive characterisation of the compressive behaviour of hydrogels using a new modelling procedure and redefining compression testing

Jairan Nafar Dastgerdi; Janne T. Koivisto; Olli Orell; Pantea Rava; Jarno Jokinen; Mikko Kanerva; Minna Kellomäki

doi:10.1016/j.mtcomm.2021.102518

Comprehensive characterisation of the compressive behaviour of hydrogels using a new modelling procedure and redefining compression testing

Jairan Nafar Dastgerdi^*
, Janne T. Koivisto
, Olli Orell
, Pantea Rava
, Jarno Jokinen
, Mikko Kanerva
, Minna Kellomäki

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

16 Citations (Scopus)

136 Downloads (Pure)

Abstract

The aim of tissue engineering is the regeneration of damaged tissue or the production of representative tissue organoids in vitro. To achieve this, one approach is to use hydrogels, water-swollen hydrophilic and crosslinked polymer networks, that can accommodate encapsulation of living cells and help the regeneration process. Even though mechanically biomimicking target tissue is important for a favorable cell response, the mechanical characterisation of tissues or hydrogels is not yet a fully defined process with various possible models and methods existing. In this paper, for the first time, a specific procedure and model has been suggested for the discussion of the nonlinear stress-strain relationship in large deformations of hydrogels. Moreover, this approach has comprehensively characterised the compressive material performance of hydrogels in a theoretical framework. To present the performance and utility of the introduced procedure, it is used with two different compositions of bioamine crosslinked gellan gum hydrogel. In addition, a three-dimensional digital image correlation technique has been utilized together with compression testing to measure the actual force and deformation in unconfined compression. The material model parameters were obtained to represent nonlinear stress-strain behaviour and the viscoelastic response (relaxation) of gellan gum hydrogel in compression.

Original language	English
Article number	102518
Number of pages	14
Journal	Materials Today Communications
Volume	28
DOIs	https://doi.org/10.1016/j.mtcomm.2021.102518
Publication status	Published - Sept 2021
Publication type	A1 Journal article-refereed

Funding

J.T. Koivisto and M. Kellomäki would like to thank the Human Spare Parts program of Business Finland and the Center of Excellence – Body on Chip (312409, 326587, 336663) of the Academy of Finland for the funding of this research. J.T. Koivisto would also like to acknowledge the support given by the Finnish Cultural Foundation the Pirkanmaa Regional Fund personal grant number 50151501 . J. Nafar Dastgerdi, O. Orell and M. Kanerva would like to thank the LuxTurrim5G project grant by Business Finland and the related subtask (10098/31/2016) about compression testing of polymers and polymer composites carried out by Tampere University of Technology. The authors wish to thank Peter Heath for help with language checking and proof-reading the manuscript. CSC–IT Center for Science (Finland) is acknowledged for computational resources. J.T. Koivisto and M. Kellom?ki would like to thank the Human Spare Parts program of Business Finland and the Center of Excellence ? Body on Chip (312409, 326587, 336663) of the Academy of Finlandfor the funding of this research. J.T. Koivisto would also like to acknowledge the support given by the Finnish Cultural Foundation the Pirkanmaa Regional Fund personal grant number 50151501. J. Nafar Dastgerdi, O. Orell and M. Kanerva would like to thank the LuxTurrim5G project grant by Business Finlandand the related subtask (10098/31/2016) about compression testing of polymers and polymer composites carried out by Tampere University of Technology. The authors wish to thank Peter Heath for help with language checking and proof-reading the manuscript. CSC?IT Center for Science (Finland) is acknowledged for computational resources.

Keywords

Compression testing
Gellan gum
Hydrogel
Mechanical properties
Viscoelastic deformation

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Materials Chemistry

Access to Document

10.1016/j.mtcomm.2021.102518

(Accepted Manuscript) Dastgerdi & Koivisto 2021 - Comprehensive characterisation of the compressive behaviour of hydrogels using a new modelling procedure and redefining compression testingAccepted author manuscript, 1.95 MBLicence: CC BY-NC-ND

https://urn.fi/URN:NBN:fi:tuni-202211018077Licence: CC BY-NC-ND

Cite this

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title = "Comprehensive characterisation of the compressive behaviour of hydrogels using a new modelling procedure and redefining compression testing",

abstract = "The aim of tissue engineering is the regeneration of damaged tissue or the production of representative tissue organoids in vitro. To achieve this, one approach is to use hydrogels, water-swollen hydrophilic and crosslinked polymer networks, that can accommodate encapsulation of living cells and help the regeneration process. Even though mechanically biomimicking target tissue is important for a favorable cell response, the mechanical characterisation of tissues or hydrogels is not yet a fully defined process with various possible models and methods existing. In this paper, for the first time, a specific procedure and model has been suggested for the discussion of the nonlinear stress-strain relationship in large deformations of hydrogels. Moreover, this approach has comprehensively characterised the compressive material performance of hydrogels in a theoretical framework. To present the performance and utility of the introduced procedure, it is used with two different compositions of bioamine crosslinked gellan gum hydrogel. In addition, a three-dimensional digital image correlation technique has been utilized together with compression testing to measure the actual force and deformation in unconfined compression. The material model parameters were obtained to represent nonlinear stress-strain behaviour and the viscoelastic response (relaxation) of gellan gum hydrogel in compression.",

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note = "Funding Information: J.T. Koivisto and M. Kellom{\"a}ki would like to thank the Human Spare Parts program of Business Finland and the Center of Excellence {\textendash} Body on Chip (312409, 326587, 336663) of the Academy of Finland for the funding of this research. J.T. Koivisto would also like to acknowledge the support given by the Finnish Cultural Foundation the Pirkanmaa Regional Fund personal grant number 50151501 . J. Nafar Dastgerdi, O. Orell and M. Kanerva would like to thank the LuxTurrim5G project grant by Business Finland and the related subtask (10098/31/2016) about compression testing of polymers and polymer composites carried out by Tampere University of Technology. The authors wish to thank Peter Heath for help with language checking and proof-reading the manuscript. CSC{\textendash}IT Center for Science (Finland) is acknowledged for computational resources. Funding Information: J.T. Koivisto and M. Kellom?ki would like to thank the Human Spare Parts program of Business Finland and the Center of Excellence ? Body on Chip (312409, 326587, 336663) of the Academy of Finlandfor the funding of this research. J.T. Koivisto would also like to acknowledge the support given by the Finnish Cultural Foundation the Pirkanmaa Regional Fund personal grant number 50151501. J. Nafar Dastgerdi, O. Orell and M. Kanerva would like to thank the LuxTurrim5G project grant by Business Finlandand the related subtask (10098/31/2016) about compression testing of polymers and polymer composites carried out by Tampere University of Technology. The authors wish to thank Peter Heath for help with language checking and proof-reading the manuscript. CSC?IT Center for Science (Finland) is acknowledged for computational resources. Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

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doi = "10.1016/j.mtcomm.2021.102518",

language = "English",

volume = "28",

journal = "Materials Today Communications",

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AU - Nafar Dastgerdi, Jairan

AU - Koivisto, Janne T.

AU - Orell, Olli

AU - Rava, Pantea

AU - Jokinen, Jarno

AU - Kanerva, Mikko

AU - Kellomäki, Minna

N1 - Funding Information: J.T. Koivisto and M. Kellomäki would like to thank the Human Spare Parts program of Business Finland and the Center of Excellence – Body on Chip (312409, 326587, 336663) of the Academy of Finland for the funding of this research. J.T. Koivisto would also like to acknowledge the support given by the Finnish Cultural Foundation the Pirkanmaa Regional Fund personal grant number 50151501 . J. Nafar Dastgerdi, O. Orell and M. Kanerva would like to thank the LuxTurrim5G project grant by Business Finland and the related subtask (10098/31/2016) about compression testing of polymers and polymer composites carried out by Tampere University of Technology. The authors wish to thank Peter Heath for help with language checking and proof-reading the manuscript. CSC–IT Center for Science (Finland) is acknowledged for computational resources. Funding Information: J.T. Koivisto and M. Kellom?ki would like to thank the Human Spare Parts program of Business Finland and the Center of Excellence ? Body on Chip (312409, 326587, 336663) of the Academy of Finlandfor the funding of this research. J.T. Koivisto would also like to acknowledge the support given by the Finnish Cultural Foundation the Pirkanmaa Regional Fund personal grant number 50151501. J. Nafar Dastgerdi, O. Orell and M. Kanerva would like to thank the LuxTurrim5G project grant by Business Finlandand the related subtask (10098/31/2016) about compression testing of polymers and polymer composites carried out by Tampere University of Technology. The authors wish to thank Peter Heath for help with language checking and proof-reading the manuscript. CSC?IT Center for Science (Finland) is acknowledged for computational resources. Publisher Copyright: © 2021 Elsevier Ltd

PY - 2021/9

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N2 - The aim of tissue engineering is the regeneration of damaged tissue or the production of representative tissue organoids in vitro. To achieve this, one approach is to use hydrogels, water-swollen hydrophilic and crosslinked polymer networks, that can accommodate encapsulation of living cells and help the regeneration process. Even though mechanically biomimicking target tissue is important for a favorable cell response, the mechanical characterisation of tissues or hydrogels is not yet a fully defined process with various possible models and methods existing. In this paper, for the first time, a specific procedure and model has been suggested for the discussion of the nonlinear stress-strain relationship in large deformations of hydrogels. Moreover, this approach has comprehensively characterised the compressive material performance of hydrogels in a theoretical framework. To present the performance and utility of the introduced procedure, it is used with two different compositions of bioamine crosslinked gellan gum hydrogel. In addition, a three-dimensional digital image correlation technique has been utilized together with compression testing to measure the actual force and deformation in unconfined compression. The material model parameters were obtained to represent nonlinear stress-strain behaviour and the viscoelastic response (relaxation) of gellan gum hydrogel in compression.

AB - The aim of tissue engineering is the regeneration of damaged tissue or the production of representative tissue organoids in vitro. To achieve this, one approach is to use hydrogels, water-swollen hydrophilic and crosslinked polymer networks, that can accommodate encapsulation of living cells and help the regeneration process. Even though mechanically biomimicking target tissue is important for a favorable cell response, the mechanical characterisation of tissues or hydrogels is not yet a fully defined process with various possible models and methods existing. In this paper, for the first time, a specific procedure and model has been suggested for the discussion of the nonlinear stress-strain relationship in large deformations of hydrogels. Moreover, this approach has comprehensively characterised the compressive material performance of hydrogels in a theoretical framework. To present the performance and utility of the introduced procedure, it is used with two different compositions of bioamine crosslinked gellan gum hydrogel. In addition, a three-dimensional digital image correlation technique has been utilized together with compression testing to measure the actual force and deformation in unconfined compression. The material model parameters were obtained to represent nonlinear stress-strain behaviour and the viscoelastic response (relaxation) of gellan gum hydrogel in compression.

KW - Compression testing

KW - Gellan gum

KW - Hydrogel

KW - Mechanical properties

KW - Viscoelastic deformation

U2 - 10.1016/j.mtcomm.2021.102518

DO - 10.1016/j.mtcomm.2021.102518

M3 - Article

AN - SCOPUS:85107997063

SN - 2352-4928

VL - 28

JO - Materials Today Communications

JF - Materials Today Communications

M1 - 102518

ER -

Comprehensive characterisation of the compressive behaviour of hydrogels using a new modelling procedure and redefining compression testing

Abstract

Funding

Keywords

Publication forum classification

ASJC Scopus subject areas

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