Computational Models of Astrocyte Function at Glutamatergic Synapses

Kerstin Lenk; Audrey Denizot; Barbara Genocchi; Ippa Seppälä; Marsa Taheri; Suhita Nadkarni

doi:10.1007/978-1-0716-3742-5_11

Computational Models of Astrocyte Function at Glutamatergic Synapses

Kerstin Lenk, Audrey Denizot, Barbara Genocchi, Ippa Seppälä, Marsa Taheri, Suhita Nadkarni

Faculty of Medicine and Health Technology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Scientific › peer-review

Abstract

At tripartite synapses, astrocytes are in close contact with neurons and contribute to various functions, from synaptic transmission, maintenance of ion homeostasis, and glutamate uptake to metabolism. However, disentangling the precise contribution of astrocytes to those phenomena and the underlying biochemical mechanisms is remarkably challenging. This notably results from their highly ramified morphology, the nanoscopic size of the majority of astrocyte processes, and the poorly understood information encoded by their spatiotemporally diverse calcium signals. This book chapter presents selected computational models of the involvement of astrocytes in glutamatergic transmission. The goal of this chapter is to present representative models of astrocyte function in conjunction with the biological questions they can investigate.

Original language	English
Title of host publication	New Technologies for Glutamate Interaction
Subtitle of host publication	Neurons and Glia
Editors	Maria Kukley
Publisher	Humana Press
Pages	229-263
Number of pages	35
ISBN (Electronic)	978-1-0716-3742-5
ISBN (Print)	978-1-0716-3741-8
DOIs	https://doi.org/10.1007/978-1-0716-3742-5_11
Publication status	Published - 2024
Publication type	A3 Book chapter

Publication series

Name	Neuromethods
Volume	2780
ISSN (Print)	0893-2336
ISSN (Electronic)	1940-6045

Keywords

Calcium signaling
Computational neuroscience
Glutamatergic transmission
Simulation
Tripartite synapses

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

General Neuroscience
General Biochemistry,Genetics and Molecular Biology
General Pharmacology, Toxicology and Pharmaceutics
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-1-0716-3742-5_11

https://research.utu.fi/converis/portal/detail/Publication/393291670Licence: Unspecified

Cite this

@inbook{514396c02a674254b074be015ba1c00c,

title = "Computational Models of Astrocyte Function at Glutamatergic Synapses",

abstract = "At tripartite synapses, astrocytes are in close contact with neurons and contribute to various functions, from synaptic transmission, maintenance of ion homeostasis, and glutamate uptake to metabolism. However, disentangling the precise contribution of astrocytes to those phenomena and the underlying biochemical mechanisms is remarkably challenging. This notably results from their highly ramified morphology, the nanoscopic size of the majority of astrocyte processes, and the poorly understood information encoded by their spatiotemporally diverse calcium signals. This book chapter presents selected computational models of the involvement of astrocytes in glutamatergic transmission. The goal of this chapter is to present representative models of astrocyte function in conjunction with the biological questions they can investigate.",

keywords = "Calcium signaling, Computational neuroscience, Glutamatergic transmission, Simulation, Tripartite synapses",

author = "Kerstin Lenk and Audrey Denizot and Barbara Genocchi and Ippa Sepp{\"a}l{\"a} and Marsa Taheri and Suhita Nadkarni",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2024.",

year = "2024",

doi = "10.1007/978-1-0716-3742-5_11",

language = "English",

isbn = "978-1-0716-3741-8",

series = "Neuromethods",

publisher = "Humana Press",

pages = "229--263",

editor = "Maria Kukley",

booktitle = "New Technologies for Glutamate Interaction",

address = "United States",

}

Computational Models of Astrocyte Function at Glutamatergic Synapses. / Lenk, Kerstin; Denizot, Audrey; Genocchi, Barbara et al.
New Technologies for Glutamate Interaction: Neurons and Glia. ed. / Maria Kukley. Humana Press, 2024. p. 229-263 (Neuromethods; Vol. 2780).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Scientific › peer-review

TY - CHAP

T1 - Computational Models of Astrocyte Function at Glutamatergic Synapses

AU - Lenk, Kerstin

AU - Denizot, Audrey

AU - Genocchi, Barbara

AU - Seppälä, Ippa

AU - Taheri, Marsa

AU - Nadkarni, Suhita

N1 - Publisher Copyright: © The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2024.

PY - 2024

Y1 - 2024

N2 - At tripartite synapses, astrocytes are in close contact with neurons and contribute to various functions, from synaptic transmission, maintenance of ion homeostasis, and glutamate uptake to metabolism. However, disentangling the precise contribution of astrocytes to those phenomena and the underlying biochemical mechanisms is remarkably challenging. This notably results from their highly ramified morphology, the nanoscopic size of the majority of astrocyte processes, and the poorly understood information encoded by their spatiotemporally diverse calcium signals. This book chapter presents selected computational models of the involvement of astrocytes in glutamatergic transmission. The goal of this chapter is to present representative models of astrocyte function in conjunction with the biological questions they can investigate.

AB - At tripartite synapses, astrocytes are in close contact with neurons and contribute to various functions, from synaptic transmission, maintenance of ion homeostasis, and glutamate uptake to metabolism. However, disentangling the precise contribution of astrocytes to those phenomena and the underlying biochemical mechanisms is remarkably challenging. This notably results from their highly ramified morphology, the nanoscopic size of the majority of astrocyte processes, and the poorly understood information encoded by their spatiotemporally diverse calcium signals. This book chapter presents selected computational models of the involvement of astrocytes in glutamatergic transmission. The goal of this chapter is to present representative models of astrocyte function in conjunction with the biological questions they can investigate.

KW - Calcium signaling

KW - Computational neuroscience

KW - Glutamatergic transmission

KW - Simulation

KW - Tripartite synapses

U2 - 10.1007/978-1-0716-3742-5_11

DO - 10.1007/978-1-0716-3742-5_11

M3 - Chapter

AN - SCOPUS:85189523677

SN - 978-1-0716-3741-8

T3 - Neuromethods

SP - 229

EP - 263

BT - New Technologies for Glutamate Interaction

A2 - Kukley, Maria

PB - Humana Press

ER -

Computational Models of Astrocyte Function at Glutamatergic Synapses

Abstract

Publication series

Keywords

Publication forum classification

ASJC Scopus subject areas

UN SDGs

Access to Document

Fingerprint

Cite this