Configurable multi-wavelength laser light engine for endoscopic fluorescence imaging

Zoe Ylöniemi, Visa Kaivosoja, Lasse Orsila, Tero Vierimaa, Petteri Uusimaa

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review


Multiple clinically approved dyes and several new dyes currently in clinical studies are used for fluorescence-guided surgery, diagnosis and imaging. These present a wide range of absorption and emission spectra and create a demand for endoscopic illumination sources with multiple wavelengths. Fluorescent imaging with simultaneous white light overlay image benefit from laser light sources for fluorescence excitation and white light illumination to allow for easy spectral filtering on imaging side. Emerging applications with imaging of two or more complementary fluorescent dyes further adds to desire for a configurable multi-wavelength endoscopic light source. The multi-wavelength configurable and cloud connected oncology laser platform Modulight ML7710 was developed further to accommodate the light engine requirements of real-time multi-wavelength endoscopic fluorescence imaging. The configurable medical illumination platform enables simultaneous multi-wavelength fluorescence excitation with wide dynamic range and color balance adjustable RGB white light illumination. Multi-wavelength light output functionality was further developed to support industry standard endoscopic light guides without the need of additional external optical elements. Laser light sources for imaging typically suffer from unwanted speckle patterns. This issue is solved with internal speckle remover which greatly reduces speckle contrast even when used with high-speed imaging applications. The platform also offers possibility for spectral measurement of fluorescence from the target to the supplement or facilitate high-resolution imaging. The configurable touchscreen user interface allows for simple application for specific operation and cloud-based connectivity enables modern configuration, data logging, planning and control with platform for future machine learning and AI analysis.

Original languageEnglish
Title of host publicationEndoscopic Microscopy XVII
EditorsGuillermo J. Tearney, Thomas D. Wang, Melissa J. Suter
Number of pages6
ISBN (Electronic)9781510647459
Publication statusPublished - 2022
Publication typeA4 Article in conference proceedings
EventEndoscopic Microscopy - San Francisco, United States
Duration: 22 Jan 202227 Jan 2022
Conference number: XVII

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceEndoscopic Microscopy
Country/TerritoryUnited States
CitySan Francisco


  • endoscopy
  • fluorescence imaging
  • medical laser
  • multi-wavelength platform
  • speckle removal
  • theranostics

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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