Consumption of Yoghurt and Other Dairy Products and Risk of Colorectal Cancer in Iran: The IROPICAN Study

Giulia Collatuzzo, Monireh Sadat Seyyedsalehi, Abbas Rezaeianzadeh, Maryam Marzban, Hamideh Rashidian, Maryam Hadji, Farin Kamangar, Arash Etemadi, Eero Pukkala, Kazem Zendehdel, Paolo Boffetta

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background: There is evidence of an inverse association between yoghurt intake and risk of colorectal cancer (CRC). We aimed at investigating the association between the intake of yoghurt and other dairy foods consumed in Iran and CRC risk. Methods: Our analysis included 4070 subjects within the IROPICAN (Iran Study of Opium and Cancer) study. Detailed information was collected by the use of validated questionnaires. We estimated adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between the intake of total dairy products, and, separately, of yo-ghurt, milk, cheese, kashk, dough, cream, ice cream, and other milk products, and CRC using un-conditional logistic regression analyses. The intake was categorized in tertiles. Results: Overall, we analyzed 865 cases and 3205 controls. Total dairy products intake was not associated with CRC. The OR for one tertile increase (OR_T) in yoghurt intake was 0.97 (95% CI 0.87–1.08) for CRC and 0.66 (95% CI 0.52–0.84) for proximal colon cancer. Cream intake was associated with CRC (OR_T3 = 1.33, 95% CI 1.08–1.64), colon (OR_T3 = 1.37, 95% CI 1.03–1.81), and proximal cancer (OR_T3 = 1.29, 95% CI 1.04–1.61). The OR of distal colon cancer for ice cream intake was 0.59 (95% CI 0.43–0.82). Other dairy products were not associated with CRC risk.

Original languageEnglish
Article number2506
Number of pages15
JournalNUTRIENTS
Volume14
Issue number12
DOIs
Publication statusPublished - Jun 2022
Publication typeA1 Journal article-refereed

Keywords

  • colon
  • colorectal cancer
  • dairy products
  • diet
  • nutrition epidemiology
  • yoghurt

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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