COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021: a test-negative case–control study

Mustafa Mahfuz; Md Ashraful Alam; Shad  Mohammad Fahim; S M Tafsir Hasan; Monira Sarmin; Subhasish Das; Ishita Mostafa; Shahana Parveen; Mustafizur  Rahman; Shams E Arifeen; John D. Clemens; Tahmeed Ahmed

doi:10.1136/bmjopen-2021-058074

COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021: a test-negative case–control study

Mustafa Mahfuz, Md Ashraful Alam, Shad Mohammad Fahim, S M Tafsir Hasan, Monira Sarmin, Subhasish Das, Ishita Mostafa, Shahana Parveen, Mustafizur Rahman, Shams E Arifeen, John D. Clemens, Tahmeed Ahmed

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Abstract

Objective
To identify factors associated with COVID- 19 positivity among staff and their family members of icddr,b, a health research institute located in Bangladesh.

Setting
Dhaka, Bangladesh.

Participants
A total of 4295 symptomatic people were tested for SARS-CoV-2 by reverse-transcription PCR between 19 March 2020 and 15 April 2021. Multivariable
logistic regression was done to identify the factors associated with COVID- 19 positivity by contrasting test positives with test negatives.

Result
Forty-three per cent of the participants were tested positive for SARS-CoV-2. The median age was high in positive cases (37 years vs 34 years). Among
the positive cases, 97% were recovered, 2.1% had reinfections, 24 died and 41 were active cases as of 15 April 2021. Multivariable regression analysis showed that age more than 60 years (adjusted OR (aOR)=2.1, 95% CI 1.3 to 3.3; pwere tested negative.

Conclusions
The study findings suggest that older age, fever, cough and anosmia were associated with COVID- 19 among the study participants.

Original language	English
Number of pages	10
Journal	BMJ Open
Volume	12
Issue number	6
DOIs	https://doi.org/10.1136/bmjopen-2021-058074
Publication status	Published - 1 Jun 2022
Publication type	A1 Journal article-refereed

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Publication forum level 1

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e058074.full-1Final published version, 744 KBLicence: CC BY-NC

https://urn.fi/URN:NBN:fi:tuni-202303062754Licence: CC BY-NC

Cite this

Mahfuz, M., Alam, M. A., Mohammad Fahim, S., Hasan, S. M. T., Sarmin, M., Das, S., Mostafa, I., Parveen, S., Rahman, M., Arifeen, S. E., Clemens, J. D., & Ahmed, T. (2022). COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021: a test-negative case–control study. BMJ Open, 12(6). https://doi.org/10.1136/bmjopen-2021-058074

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title = "COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021: a test-negative case–control study",

abstract = "Objective To identify factors associated with COVID- 19 positivity among staff and their family members of icddr,b, a health research institute located in Bangladesh. Setting Dhaka, Bangladesh. Participants A total of 4295 symptomatic people were tested for SARS-CoV-2 by reverse-transcription PCR between 19 March 2020 and 15 April 2021. Multivariable logistic regression was done to identify the factors associated with COVID- 19 positivity by contrasting test positives with test negatives.Result Forty-three per cent of the participants were tested positive for SARS-CoV-2. The median age was high in positive cases (37 years vs 34 years). Among the positive cases, 97% were recovered, 2.1% had reinfections, 24 died and 41 were active cases as of 15 April 2021. Multivariable regression analysis showed that age more than 60 years (adjusted OR (aOR)=2.1, 95% CI 1.3 to 3.3; pwere tested negative.Conclusions The study findings suggest that older age, fever, cough and anosmia were associated with COVID- 19 among the study participants.",

author = "Mustafa Mahfuz and Alam, {Md Ashraful} and {Mohammad Fahim}, Shad and Hasan, {S M Tafsir} and Monira Sarmin and Subhasish Das and Ishita Mostafa and Shahana Parveen and Mustafizur Rahman and Arifeen, {Shams E} and Clemens, {John D.} and Tahmeed Ahmed",

year = "2022",

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doi = "10.1136/bmjopen-2021-058074",

language = "English",

volume = "12",

journal = "BMJ Open",

issn = "2044-6055",

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number = "6",

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Mahfuz, M, Alam, MA, Mohammad Fahim, S, Hasan, SMT, Sarmin, M, Das, S, Mostafa, I, Parveen, S, Rahman, M, Arifeen, SE, Clemens, JD & Ahmed, T 2022, 'COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021: a test-negative case–control study', BMJ Open, vol. 12, no. 6. https://doi.org/10.1136/bmjopen-2021-058074

TY - JOUR

T1 - COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021

T2 - a test-negative case–control study

AU - Mahfuz, Mustafa

AU - Alam, Md Ashraful

AU - Mohammad Fahim, Shad

AU - Hasan, S M Tafsir

AU - Sarmin, Monira

AU - Das, Subhasish

AU - Mostafa, Ishita

AU - Parveen, Shahana

AU - Rahman, Mustafizur

AU - Arifeen, Shams E

AU - Clemens, John D.

AU - Ahmed, Tahmeed

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Objective To identify factors associated with COVID- 19 positivity among staff and their family members of icddr,b, a health research institute located in Bangladesh. Setting Dhaka, Bangladesh. Participants A total of 4295 symptomatic people were tested for SARS-CoV-2 by reverse-transcription PCR between 19 March 2020 and 15 April 2021. Multivariable logistic regression was done to identify the factors associated with COVID- 19 positivity by contrasting test positives with test negatives.Result Forty-three per cent of the participants were tested positive for SARS-CoV-2. The median age was high in positive cases (37 years vs 34 years). Among the positive cases, 97% were recovered, 2.1% had reinfections, 24 died and 41 were active cases as of 15 April 2021. Multivariable regression analysis showed that age more than 60 years (adjusted OR (aOR)=2.1, 95% CI 1.3 to 3.3; pwere tested negative.Conclusions The study findings suggest that older age, fever, cough and anosmia were associated with COVID- 19 among the study participants.

AB - Objective To identify factors associated with COVID- 19 positivity among staff and their family members of icddr,b, a health research institute located in Bangladesh. Setting Dhaka, Bangladesh. Participants A total of 4295 symptomatic people were tested for SARS-CoV-2 by reverse-transcription PCR between 19 March 2020 and 15 April 2021. Multivariable logistic regression was done to identify the factors associated with COVID- 19 positivity by contrasting test positives with test negatives.Result Forty-three per cent of the participants were tested positive for SARS-CoV-2. The median age was high in positive cases (37 years vs 34 years). Among the positive cases, 97% were recovered, 2.1% had reinfections, 24 died and 41 were active cases as of 15 April 2021. Multivariable regression analysis showed that age more than 60 years (adjusted OR (aOR)=2.1, 95% CI 1.3 to 3.3; pwere tested negative.Conclusions The study findings suggest that older age, fever, cough and anosmia were associated with COVID- 19 among the study participants.

U2 - 10.1136/bmjopen-2021-058074

DO - 10.1136/bmjopen-2021-058074

M3 - Article

SN - 2044-6055

VL - 12

JO - BMJ Open

JF - BMJ Open

IS - 6

ER -

COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021: a test-negative case–control study

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