Crystal structure of an in vitro affinity- and specificity-matured anti-testosterone Fab in complex with testosterone. Improved affinity results from small structural changes within the variable domains

Jarkko Valjakka; Ari Hemminki; Seija Niemi; Hans Söderlund; Kristiina Takkinen; Juha Rouvinen

Crystal structure of an in vitro affinity- and specificity-matured anti-testosterone Fab in complex with testosterone. Improved affinity results from small structural changes within the variable domains

Jarkko Valjakka, Ari Hemminki, Seija Niemi, Hans Söderlund, Kristiina Takkinen, Juha Rouvinen

Research output: Contribution to journal › Article › Scientific › peer-review

48 Citations (Scopus)

Original language	English
Pages (from-to)	44021-44027
Journal	Journal of Biological Chemistry
Volume	Nov 15;277(46)
Publication status	Published - 2002
Externally published	Yes
Publication type	A1 Journal article-refereed

Cite this

@article{ac420859bbce46caa8197d88836191f3,

title = "Crystal structure of an in vitro affinity- and specificity-matured anti-testosterone Fab in complex with testosterone. Improved affinity results from small structural changes within the variable domains",

author = "Jarkko Valjakka and Ari Hemminki and Seija Niemi and Hans S{\"o}derlund and Kristiina Takkinen and Juha Rouvinen",

year = "2002",

language = "English",

volume = "Nov 15;277(46)",

pages = "44021--44027",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology",

}

Crystal structure of an in vitro affinity- and specificity-matured anti-testosterone Fab in complex with testosterone. Improved affinity results from small structural changes within the variable domains. / Valjakka, Jarkko; Hemminki, Ari; Niemi, Seija et al.
In: Journal of Biological Chemistry, Vol. Nov 15;277(46), 2002, p. 44021-44027.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Crystal structure of an in vitro affinity- and specificity-matured anti-testosterone Fab in complex with testosterone. Improved affinity results from small structural changes within the variable domains

AU - Valjakka, Jarkko

AU - Hemminki, Ari

AU - Niemi, Seija

AU - Söderlund, Hans

AU - Takkinen, Kristiina

AU - Rouvinen, Juha

PY - 2002

Y1 - 2002

M3 - Article

SN - 0021-9258

VL - Nov 15;277(46)

SP - 44021

EP - 44027

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

ER -