Crystal structure of an in vitro affinity- and specificity-matured anti-testosterone Fab in complex with testosterone. Improved affinity results from small structural changes within the variable domains

Jarkko Valjakka; Ari Hemminki; Seija Niemi; Hans Söderlund; Kristiina Takkinen; Juha Rouvinen

Crystal structure of an in vitro affinity- and specificity-matured anti-testosterone Fab in complex with testosterone. Improved affinity results from small structural changes within the variable domains

Jarkko Valjakka
, Ari Hemminki
, Seija Niemi
, Hans Söderlund
, Kristiina Takkinen
, Juha Rouvinen

Research output: Contribution to journal › Article › Scientific › peer-review

50 Citations (Scopus)

Original language	English
Pages (from-to)	44021-44027
Journal	Journal of Biological Chemistry
Volume	Nov 15;277(46)
Publication status	Published - 2002
Externally published	Yes
Publication type	A1 Journal article-refereed

Cite this

@article{ac420859bbce46caa8197d88836191f3,

title = "Crystal structure of an in vitro affinity- and specificity-matured anti-testosterone Fab in complex with testosterone. Improved affinity results from small structural changes within the variable domains",

author = "Jarkko Valjakka and Ari Hemminki and Seija Niemi and Hans S{\"o}derlund and Kristiina Takkinen and Juha Rouvinen",

year = "2002",

language = "English",

volume = "Nov 15;277(46)",

pages = "44021--44027",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

}

Crystal structure of an in vitro affinity- and specificity-matured anti-testosterone Fab in complex with testosterone. Improved affinity results from small structural changes within the variable domains. / Valjakka, Jarkko; Hemminki, Ari; Niemi, Seija et al.
In: Journal of Biological Chemistry, Vol. Nov 15;277(46), 2002, p. 44021-44027.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Crystal structure of an in vitro affinity- and specificity-matured anti-testosterone Fab in complex with testosterone. Improved affinity results from small structural changes within the variable domains

AU - Valjakka, Jarkko

AU - Hemminki, Ari

AU - Niemi, Seija

AU - Söderlund, Hans

AU - Takkinen, Kristiina

AU - Rouvinen, Juha

PY - 2002

Y1 - 2002

M3 - Article

SN - 0021-9258

VL - Nov 15;277(46)

SP - 44021

EP - 44027

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

ER -