Current perspectives of limbal-derived stem cells and its application in ocular surface regeneration and limbal stem cell transplantation

Vivek Singh; Anil Tiwari; Abhinav Reddy Kethiri; Virender Singh Sangwan

doi:10.1002/sctm.20-0408

Current perspectives of limbal-derived stem cells and its application in ocular surface regeneration and limbal stem cell transplantation

Vivek Singh, Anil Tiwari, Abhinav Reddy Kethiri, Virender Singh Sangwan

Research output: Contribution to journal › Review Article › peer-review

27 Citations (Scopus)

Abstract

Limbal stem cells are involved in replenishing and maintaining the epithelium of the cornea. Damage to the limbus due to chemical/physical injury, infections, or genetic disorders leads to limbal stem cell deficiency (LSCD) with partial or total vision loss. Presently, LSCD is treated by transplanting limbal stem cells from the healthy eye of the recipient, living-related, or cadaveric donors. This review discusses limbal-derived stem cells, the importance of extracellular matrix in stem cell niche maintenance, the historical perspective of treating LSCD, including related advantages and limitations, and our experience of limbal stem cell transplantation over the decades.

Original language	English
Pages (from-to)	1121-1128
Number of pages	8
Journal	Stem Cells Translational Medicine
Volume	10
Issue number	8
DOIs	https://doi.org/10.1002/sctm.20-0408
Publication status	Published - Aug 2021
Externally published	Yes
Publication type	A2 Review article in a scientific journal

Keywords

Cell Transplantation
Cells, Cultured
Corneal Diseases/therapy
Epithelium, Corneal
Humans
Limbus Corneae
Stem Cell Transplantation

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10.1002/sctm.20-0408Licence: CC BY

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title = "Current perspectives of limbal-derived stem cells and its application in ocular surface regeneration and limbal stem cell transplantation",

abstract = "Limbal stem cells are involved in replenishing and maintaining the epithelium of the cornea. Damage to the limbus due to chemical/physical injury, infections, or genetic disorders leads to limbal stem cell deficiency (LSCD) with partial or total vision loss. Presently, LSCD is treated by transplanting limbal stem cells from the healthy eye of the recipient, living-related, or cadaveric donors. This review discusses limbal-derived stem cells, the importance of extracellular matrix in stem cell niche maintenance, the historical perspective of treating LSCD, including related advantages and limitations, and our experience of limbal stem cell transplantation over the decades.",

keywords = "Cell Transplantation, Cells, Cultured, Corneal Diseases/therapy, Epithelium, Corneal, Humans, Limbus Corneae, Stem Cell Transplantation",

author = "Vivek Singh and Anil Tiwari and Kethiri, {Abhinav Reddy} and Sangwan, {Virender Singh}",

note = "{\textcopyright} 2021 The Authors. STEM CELLS TRANSLATIONAL MEDICINE published by Wiley Periodicals LLC on behalf of AlphaMed Press.",

year = "2021",

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doi = "10.1002/sctm.20-0408",

language = "English",

volume = "10",

pages = "1121--1128",

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T1 - Current perspectives of limbal-derived stem cells and its application in ocular surface regeneration and limbal stem cell transplantation

AU - Singh, Vivek

AU - Tiwari, Anil

AU - Kethiri, Abhinav Reddy

AU - Sangwan, Virender Singh

PY - 2021/8

Y1 - 2021/8

N2 - Limbal stem cells are involved in replenishing and maintaining the epithelium of the cornea. Damage to the limbus due to chemical/physical injury, infections, or genetic disorders leads to limbal stem cell deficiency (LSCD) with partial or total vision loss. Presently, LSCD is treated by transplanting limbal stem cells from the healthy eye of the recipient, living-related, or cadaveric donors. This review discusses limbal-derived stem cells, the importance of extracellular matrix in stem cell niche maintenance, the historical perspective of treating LSCD, including related advantages and limitations, and our experience of limbal stem cell transplantation over the decades.

AB - Limbal stem cells are involved in replenishing and maintaining the epithelium of the cornea. Damage to the limbus due to chemical/physical injury, infections, or genetic disorders leads to limbal stem cell deficiency (LSCD) with partial or total vision loss. Presently, LSCD is treated by transplanting limbal stem cells from the healthy eye of the recipient, living-related, or cadaveric donors. This review discusses limbal-derived stem cells, the importance of extracellular matrix in stem cell niche maintenance, the historical perspective of treating LSCD, including related advantages and limitations, and our experience of limbal stem cell transplantation over the decades.

KW - Cell Transplantation

KW - Cells, Cultured

KW - Corneal Diseases/therapy

KW - Epithelium, Corneal

KW - Humans

KW - Limbus Corneae

KW - Stem Cell Transplantation

U2 - 10.1002/sctm.20-0408

DO - 10.1002/sctm.20-0408

M3 - Review Article

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SN - 2157-6564

VL - 10

SP - 1121

EP - 1128

JO - Stem Cells Translational Medicine

JF - Stem Cells Translational Medicine

IS - 8

ER -

Current perspectives of limbal-derived stem cells and its application in ocular surface regeneration and limbal stem cell transplantation

Abstract

Keywords

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