Defined-size DNA triple crossover construct for molecular electronics: Modification, positioning and conductance properties

Veikko Linko; Jenni Leppiniemi; Seppo Tapio Paasonen; Vesa P. Hytönen; J. Jussi Toppari

doi:10.1088/0957-4484/22/27/275610

Defined-size DNA triple crossover construct for molecular electronics: Modification, positioning and conductance properties

Veikko Linko, Jenni Leppiniemi, Seppo Tapio Paasonen, Vesa P. Hytönen, J. Jussi Toppari

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

We present a novel, defined-size, small and rigid DNA template, a so-called B-A-B complex, based on DNA triple crossover motifs (TX tiles), which can be utilized in molecular scale patterning for nanoelectronics, plasmonics and sensing applications. The feasibility of the designed construct is demonstrated by functionalizing the TX tiles with one biotin-triethylene glycol (TEG) and efficiently decorating them with streptavidin, and furthermore by positioning and anchoring single thiol-modified B-A-B complexes to certain locations on a chip via dielectrophoretic trapping. Finally, we characterize the conductance properties of the non-functionalized construct, first by measuring DC conductivity and second by utilizing AC impedance spectroscopy in order to describe the conductivity mechanism of a single B-A-B complex using a detailed equivalent circuit model. This analysis also reveals further information about the conductivity of DNA structures in general.

Original language	English
Article number	275610
Pages (from-to)	275610
Journal	Nanotechnology
Volume	22
Issue number	27
DOIs	https://doi.org/10.1088/0957-4484/22/27/275610
Publication status	Published - 2011
Publication type	A1 Journal article-refereed

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title = "Defined-size DNA triple crossover construct for molecular electronics: Modification, positioning and conductance properties",

abstract = "We present a novel, defined-size, small and rigid DNA template, a so-called B-A-B complex, based on DNA triple crossover motifs (TX tiles), which can be utilized in molecular scale patterning for nanoelectronics, plasmonics and sensing applications. The feasibility of the designed construct is demonstrated by functionalizing the TX tiles with one biotin-triethylene glycol (TEG) and efficiently decorating them with streptavidin, and furthermore by positioning and anchoring single thiol-modified B-A-B complexes to certain locations on a chip via dielectrophoretic trapping. Finally, we characterize the conductance properties of the non-functionalized construct, first by measuring DC conductivity and second by utilizing AC impedance spectroscopy in order to describe the conductivity mechanism of a single B-A-B complex using a detailed equivalent circuit model. This analysis also reveals further information about the conductivity of DNA structures in general.",

author = "Veikko Linko and Jenni Leppiniemi and Paasonen, {Seppo Tapio} and Hyt{\"o}nen, {Vesa P.} and {Jussi Toppari}, J.",

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T1 - Defined-size DNA triple crossover construct for molecular electronics: Modification, positioning and conductance properties

AU - Linko, Veikko

AU - Leppiniemi, Jenni

AU - Paasonen, Seppo Tapio

AU - Hytönen, Vesa P.

AU - Jussi Toppari, J.

PY - 2011

Y1 - 2011

N2 - We present a novel, defined-size, small and rigid DNA template, a so-called B-A-B complex, based on DNA triple crossover motifs (TX tiles), which can be utilized in molecular scale patterning for nanoelectronics, plasmonics and sensing applications. The feasibility of the designed construct is demonstrated by functionalizing the TX tiles with one biotin-triethylene glycol (TEG) and efficiently decorating them with streptavidin, and furthermore by positioning and anchoring single thiol-modified B-A-B complexes to certain locations on a chip via dielectrophoretic trapping. Finally, we characterize the conductance properties of the non-functionalized construct, first by measuring DC conductivity and second by utilizing AC impedance spectroscopy in order to describe the conductivity mechanism of a single B-A-B complex using a detailed equivalent circuit model. This analysis also reveals further information about the conductivity of DNA structures in general.

AB - We present a novel, defined-size, small and rigid DNA template, a so-called B-A-B complex, based on DNA triple crossover motifs (TX tiles), which can be utilized in molecular scale patterning for nanoelectronics, plasmonics and sensing applications. The feasibility of the designed construct is demonstrated by functionalizing the TX tiles with one biotin-triethylene glycol (TEG) and efficiently decorating them with streptavidin, and furthermore by positioning and anchoring single thiol-modified B-A-B complexes to certain locations on a chip via dielectrophoretic trapping. Finally, we characterize the conductance properties of the non-functionalized construct, first by measuring DC conductivity and second by utilizing AC impedance spectroscopy in order to describe the conductivity mechanism of a single B-A-B complex using a detailed equivalent circuit model. This analysis also reveals further information about the conductivity of DNA structures in general.

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DO - 10.1088/0957-4484/22/27/275610

M3 - Article

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VL - 22

SP - 275610

JO - Nanotechnology

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Defined-size DNA triple crossover construct for molecular electronics: Modification, positioning and conductance properties

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