Description of the local hemodynamic environment in intracranial aneurysm wall subdivisions

Yogesh Karnam, Fernando Mut, Alexander K. Yu, Boyle Cheng, Sepideh Amin-Hanjani, Fady T. Charbel, Henry H. Woo, Mika Niemelä, Riikka Tulamo, Behnam Rezai Jahromi, Juhana Frösen, Yasutaka Tobe, Anne M. Robertson, Juan R. Cebral

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)
2 Downloads (Pure)

Abstract

Intracranial aneurysms (IAs) pose severe health risks influenced by hemodynamics. This study focuses on the intricate characterization of hemodynamic conditions within the IA walls and their influence on bleb development, aiming to enhance understanding of aneurysm stability and the risk of rupture. The methods emphasized utilizing a comprehensive dataset of 359 IAs and 213 IA blebs from 268 patients to reconstruct patient-specific vascular models, analyzing blood flow using finite element methods to solve the unsteady Navier–Stokes equations, the segmentation of aneurysm wall subregions and the hemodynamic metrics wall shear stress (WSS), its metrics, and the critical points in WSS fields were computed and analyzed across different aneurysm subregions defined by saccular, streamwise, and topographical divisions. The results revealed significant variations in these metrics, correlating distinct hemodynamic environments with wall features on the aneurysm walls, such as bleb formation. Critical findings indicated that regions with low WSS and high OSI, particularly in the body and central regions of aneurysms, are prone to conditions that promote bleb formation. Conversely, areas exposed to high WSS and positive divergence, like the aneurysm neck, inflow, and outflow regions, exhibited a different but substantial risk profile for bleb development, influenced by flow impingements and convergences. These insights highlight the complexity of aneurysm behavior, suggesting that both high and low-shear environments can contribute to aneurysm pathology through distinct mechanisms.

Original languageEnglish
Article numbere3844
Number of pages17
JournalINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
Volume40
Issue number8
DOIs
Publication statusPublished - Aug 2024
Publication typeA1 Journal article-refereed

Keywords

  • bleb
  • CFD
  • hemodynamics
  • intracranial aneurysm
  • WSS

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • Software
  • Biomedical Engineering
  • Modelling and Simulation
  • Molecular Biology
  • Computational Theory and Mathematics
  • Applied Mathematics

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