Dexamethasone inhibits inducible nitric-oxide synthase expression and nitric oxide production by destabilizing mRNA in lipopolysaccharide-treated macrophages

R Korhonen, A Lahti, M Hämäläinen, H Kankaanranta, E Moilanen

Research output: Contribution to journalArticleScientificpeer-review

131 Citations (Scopus)
Original languageEnglish
Pages (from-to)698-704
JournalMOLECULAR PHARMACOLOGY
Volume62
Issue number3
DOIs
Publication statusPublished - 2002
Publication typeA1 Journal article-refereed

Keywords

  • activator protein 1 (ap-1)
  • cyclooxygenase 2 (cox2)
  • glucocorticoid reseptor gr
  • glucocorticoid-responsive element (gre)
  • glyceraldehyde-3-phosphate dehydrogenase (gapdh)
  • inducible nitric-oxide synthase (inos)
  • interferon-gamma (ifn-gamma)
  • lipopolysaccharide (lps)
  • nitric oxide (no)
  • nitric-oxide synthase (nos)
  • nuclear factor kappa b (nf-kb)
  • rnase protection assay (rpa)
  • tristetraprolin (ttp)

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