Abstract
The use of diazo compounds in homologation reactions is timeless. Despite the first transformations being reported almost a century ago, this class of compounds continues to be used in both academia and industry. In this chapter we cover the main methods for preparation of diazo compounds mostly used for homologations, as well as the most common homologation methods, specifically the homologation of aldehydes and ketones, carboxylic acids, and their derivatives. The topics are introduced through a brief historical perspective and compile the most relevant works on the field of homologations with diazo compounds.
| Original language | English |
|---|---|
| Title of host publication | Homologation Reactions |
| Subtitle of host publication | Reagents, Applications, and Mechanisms: Volume 1 and 2 |
| Editors | Vittorio Pace |
| Publisher | Wiley-VCH Verlag |
| Pages | 1-77 |
| Number of pages | 77 |
| Volume | 1-2 |
| ISBN (Electronic) | 9783527830237 |
| ISBN (Print) | 9783527351244 |
| DOIs | |
| Publication status | Published - 2023 |
| Publication type | A3 Book chapter |
Keywords
- Arndt–Eistert homologation
- Buchner–Curtius–Schlotterbeck reaction
- Colvin rearrangement
- Diazo compounds
- Roskamp reaction
- Seyferth–Gilbert
- Wolff rearrangement
- α-diazo carbonyl
Publication forum classification
- Publication forum level 2
ASJC Scopus subject areas
- General Chemistry
- General Chemical Engineering