Dietary Ruminant and Industrial Trans-Fatty Acids Intake and Colorectal Cancer Risk

Monireh Sadat Seyyedsalehi; Giulia Collatuzzo; Hamideh Rashidian; Maryam Hadji; Mahin Gholipour; Elham Mohebbi; Farin Kamangar; Eero Pukkala; Inge Huybrechts; Marc J. Gunter; Veronique Chajes; Paolo Boffetta; Kazem Zendehdel

doi:10.3390/nu14224912

Dietary Ruminant and Industrial Trans-Fatty Acids Intake and Colorectal Cancer Risk

Monireh Sadat Seyyedsalehi
, Giulia Collatuzzo
, Hamideh Rashidian
, Maryam Hadji
, Mahin Gholipour
, Elham Mohebbi
, Farin Kamangar
, Eero Pukkala
, Inge Huybrechts
, Marc J. Gunter
, Veronique Chajes
, Paolo Boffetta^*
, Kazem Zendehdel

^*Corresponding author for this work

Health Sciences

Research output: Contribution to journal › Article › Scientific › peer-review

13 Citations (Scopus)

19 Downloads (Pure)

Abstract

As colorectal cancer (CRC) is largely due to modifiable lifestyle habits, the awareness on its risk factors is highly important. Dietary fatty acids have been linked to CRC risk. We explored the association between dietary trans fatty acids (TFAs) intake and CRC risk. We analyzed 865 CRC cases (434 in colon and 404 in rectum) and 3206 controls of the IROPICAN study, with data collected by trained interviewers using validated questionnaires. TFAs intake (industrial and ruminant types) was categorized into quartiles. Multivariate logistic regression models were built to calculate the odds ratios (OR) for the association between CRC and TFAs. We observed a positive association between industrial TFAs and colon cancer (OR for highest vs lowest quartile [OR_Q4vsQ1] = 1.28, 95% confidence interval 1.07–1.54). A higher association was observed between industrial TFAs and CRC, occurring after 50 years of age. In addition, elaidic acid was associated with an increased risk of colon (OR_Q4vsQ1 = 1.58, 1.24–2.02) and specifically of proximal colon cancer (OR _Q4vsQ1 = 2.12, 1.40–3.20), as well as of rectum cancer (OR_Q4vsQ1 = 1.40, 1.07–1.83). An inverse association was observed between ruminant TFAs intake and colon cancer risk (OR_Q4vsQ1 = 0.80, 0.67–0.97). Industrial TFAs, such as semisolid/solid hydrogenated oils, may increase the risk of CRC, especially colon and proximal colon cancer. In contrast, ruminant TFAs do not appear to be associated with CRC. Awareness programs and regulatory actions regarding hydrogenated oils are warranted, given their high consumption through ultra-processed foods in more developed and less developed countries.

Original language	English
Article number	4912
Number of pages	13
Journal	Nutrients
Volume	14
Issue number	22
DOIs	https://doi.org/10.3390/nu14224912
Publication status	Published - Nov 2022
Publication type	A1 Journal article-refereed

Funding

This research was supported by the National Institute for Medical Research Development (NIMAD) and Foundation for cancer research (AIRC). We thank our colleagues who provided insight and expertise that greatly assisted the research, and all of them agree with all the conclusions of this paper. The study was funded by National Institute of Medical Research Development (NIMAD) (Code: IR.NIMAD.REC.1394.027) and supported by Investigator Grant N. 24706 of Fondazione AIRC.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

animal products
colorectal cancer
conjugated linoleic acid
diet
elaidic acid
industrial fat
trans fatty acid

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Food Science
Nutrition and Dietetics

Access to Document

10.3390/nu14224912Licence: CC BY

nutrients-14-04912Final published version, 256 KBLicence: CC BY

https://urn.fi/URN:NBN:fi:tuni-202212129085Licence: CC BY

Cite this

@article{dca189c109cb46cbb1faa6b92215549e,

title = "Dietary Ruminant and Industrial Trans-Fatty Acids Intake and Colorectal Cancer Risk",

abstract = "As colorectal cancer (CRC) is largely due to modifiable lifestyle habits, the awareness on its risk factors is highly important. Dietary fatty acids have been linked to CRC risk. We explored the association between dietary trans fatty acids (TFAs) intake and CRC risk. We analyzed 865 CRC cases (434 in colon and 404 in rectum) and 3206 controls of the IROPICAN study, with data collected by trained interviewers using validated questionnaires. TFAs intake (industrial and ruminant types) was categorized into quartiles. Multivariate logistic regression models were built to calculate the odds ratios (OR) for the association between CRC and TFAs. We observed a positive association between industrial TFAs and colon cancer (OR for highest vs lowest quartile [ORQ4vsQ1] = 1.28, 95\% confidence interval 1.07{\textendash}1.54). A higher association was observed between industrial TFAs and CRC, occurring after 50 years of age. In addition, elaidic acid was associated with an increased risk of colon (ORQ4vsQ1 = 1.58, 1.24{\textendash}2.02) and specifically of proximal colon cancer (OR Q4vsQ1 = 2.12, 1.40{\textendash}3.20), as well as of rectum cancer (ORQ4vsQ1 = 1.40, 1.07{\textendash}1.83). An inverse association was observed between ruminant TFAs intake and colon cancer risk (ORQ4vsQ1 = 0.80, 0.67{\textendash}0.97). Industrial TFAs, such as semisolid/solid hydrogenated oils, may increase the risk of CRC, especially colon and proximal colon cancer. In contrast, ruminant TFAs do not appear to be associated with CRC. Awareness programs and regulatory actions regarding hydrogenated oils are warranted, given their high consumption through ultra-processed foods in more developed and less developed countries.",

keywords = "animal products, colorectal cancer, conjugated linoleic acid, diet, elaidic acid, industrial fat, trans fatty acid",

author = "Seyyedsalehi, \{Monireh Sadat\} and Giulia Collatuzzo and Hamideh Rashidian and Maryam Hadji and Mahin Gholipour and Elham Mohebbi and Farin Kamangar and Eero Pukkala and Inge Huybrechts and Gunter, \{Marc J.\} and Veronique Chajes and Paolo Boffetta and Kazem Zendehdel",

note = "Funding Information: This research was supported by the National Institute for Medical Research Development (NIMAD) and Foundation for cancer research (AIRC). We thank our colleagues who provided insight and expertise that greatly assisted the research, and all of them agree with all the conclusions of this paper. Funding Information: The study was funded by National Institute of Medical Research Development (NIMAD) (Code: IR.NIMAD.REC.1394.027) and supported by Investigator Grant N. 24706 of Fondazione AIRC. Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = nov,

doi = "10.3390/nu14224912",

language = "English",

volume = "14",

journal = "Nutrients",

issn = "2072-6643",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "22",

}

TY - JOUR

T1 - Dietary Ruminant and Industrial Trans-Fatty Acids Intake and Colorectal Cancer Risk

AU - Seyyedsalehi, Monireh Sadat

AU - Collatuzzo, Giulia

AU - Rashidian, Hamideh

AU - Hadji, Maryam

AU - Gholipour, Mahin

AU - Mohebbi, Elham

AU - Kamangar, Farin

AU - Pukkala, Eero

AU - Huybrechts, Inge

AU - Gunter, Marc J.

AU - Chajes, Veronique

AU - Boffetta, Paolo

AU - Zendehdel, Kazem

N1 - Funding Information: This research was supported by the National Institute for Medical Research Development (NIMAD) and Foundation for cancer research (AIRC). We thank our colleagues who provided insight and expertise that greatly assisted the research, and all of them agree with all the conclusions of this paper. Funding Information: The study was funded by National Institute of Medical Research Development (NIMAD) (Code: IR.NIMAD.REC.1394.027) and supported by Investigator Grant N. 24706 of Fondazione AIRC. Publisher Copyright: © 2022 by the authors.

PY - 2022/11

Y1 - 2022/11

N2 - As colorectal cancer (CRC) is largely due to modifiable lifestyle habits, the awareness on its risk factors is highly important. Dietary fatty acids have been linked to CRC risk. We explored the association between dietary trans fatty acids (TFAs) intake and CRC risk. We analyzed 865 CRC cases (434 in colon and 404 in rectum) and 3206 controls of the IROPICAN study, with data collected by trained interviewers using validated questionnaires. TFAs intake (industrial and ruminant types) was categorized into quartiles. Multivariate logistic regression models were built to calculate the odds ratios (OR) for the association between CRC and TFAs. We observed a positive association between industrial TFAs and colon cancer (OR for highest vs lowest quartile [ORQ4vsQ1] = 1.28, 95% confidence interval 1.07–1.54). A higher association was observed between industrial TFAs and CRC, occurring after 50 years of age. In addition, elaidic acid was associated with an increased risk of colon (ORQ4vsQ1 = 1.58, 1.24–2.02) and specifically of proximal colon cancer (OR Q4vsQ1 = 2.12, 1.40–3.20), as well as of rectum cancer (ORQ4vsQ1 = 1.40, 1.07–1.83). An inverse association was observed between ruminant TFAs intake and colon cancer risk (ORQ4vsQ1 = 0.80, 0.67–0.97). Industrial TFAs, such as semisolid/solid hydrogenated oils, may increase the risk of CRC, especially colon and proximal colon cancer. In contrast, ruminant TFAs do not appear to be associated with CRC. Awareness programs and regulatory actions regarding hydrogenated oils are warranted, given their high consumption through ultra-processed foods in more developed and less developed countries.

AB - As colorectal cancer (CRC) is largely due to modifiable lifestyle habits, the awareness on its risk factors is highly important. Dietary fatty acids have been linked to CRC risk. We explored the association between dietary trans fatty acids (TFAs) intake and CRC risk. We analyzed 865 CRC cases (434 in colon and 404 in rectum) and 3206 controls of the IROPICAN study, with data collected by trained interviewers using validated questionnaires. TFAs intake (industrial and ruminant types) was categorized into quartiles. Multivariate logistic regression models were built to calculate the odds ratios (OR) for the association between CRC and TFAs. We observed a positive association between industrial TFAs and colon cancer (OR for highest vs lowest quartile [ORQ4vsQ1] = 1.28, 95% confidence interval 1.07–1.54). A higher association was observed between industrial TFAs and CRC, occurring after 50 years of age. In addition, elaidic acid was associated with an increased risk of colon (ORQ4vsQ1 = 1.58, 1.24–2.02) and specifically of proximal colon cancer (OR Q4vsQ1 = 2.12, 1.40–3.20), as well as of rectum cancer (ORQ4vsQ1 = 1.40, 1.07–1.83). An inverse association was observed between ruminant TFAs intake and colon cancer risk (ORQ4vsQ1 = 0.80, 0.67–0.97). Industrial TFAs, such as semisolid/solid hydrogenated oils, may increase the risk of CRC, especially colon and proximal colon cancer. In contrast, ruminant TFAs do not appear to be associated with CRC. Awareness programs and regulatory actions regarding hydrogenated oils are warranted, given their high consumption through ultra-processed foods in more developed and less developed countries.

KW - animal products

KW - colorectal cancer

KW - conjugated linoleic acid

KW - diet

KW - elaidic acid

KW - industrial fat

KW - trans fatty acid

U2 - 10.3390/nu14224912

DO - 10.3390/nu14224912

M3 - Article

AN - SCOPUS:85142645296

SN - 2072-6643

VL - 14

JO - Nutrients

JF - Nutrients

IS - 22

M1 - 4912

ER -

Dietary Ruminant and Industrial Trans-Fatty Acids Intake and Colorectal Cancer Risk

Abstract

Funding

UN SDGs

Keywords

Publication forum classification

ASJC Scopus subject areas

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