Differences in psychosocial functioning between psychotic disorders in the Finnish SUPER study

Johan Ahti, Tuula Kieseppä, Jaana Suvisaari, Kimmo Suokas, Minna Holm, Asko Wegelius, Ari Ahola-Olli, Katja Häkkinen, Olli Kampman, Markku Lähteenvuo, Tiina Paunio, Jari Tiihonen, Annamari Tuulio-Henriksson, Erkki Isometsä, the SUPER researchers

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Background: Psychotic disorders differ in their impact on psychosocial functioning. However, few studies have directly compared psychosocial functioning and its determinants between schizophrenia, schizoaffective disorder (SAD), bipolar disorder (BD), and major depressive disorder with psychotic features (psychotic MDD). Objective: We compared rates of independent living, employment, marriage, and having children between these diagnostic groups in a large national sample of participants with psychotic disorders in Finland. Methods: A cross-sectional substudy of participants (N = 9148) aged 18 to 65 years in the Finnish SUPER study, recruited nationwide from health- and social care settings and with advertisements. Psychosis diagnoses, age of onset, and hospitalizations were collected from healthcare registers. Participants were interviewed for psychosocial functioning. Associations of age of onset, hospitalizations, gender, and education with psychosocial functioning were analyzed using logistic regression models. Results: Of participants, 13.8% were employed or studying, 72.0% living independently and 32.5% had children. Overall, BD was associated with best, SAD and psychotic MDD with intermediate, and schizophrenia with worst level of psychosocial functioning. Greatest differences were found in independent living (OR 4.06 for BD vs. schizophrenia). In multivariate models, gender and number of hospitalizations predicted employment, marriage, and independent living in all diagnostic categories, and age of onset in some diagnostic categories. Conclusions: Level of functioning and psychosocial outcomes differed markedly between psychotic disorders, particularly in independent living. Outcomes were worst for schizophrenia and best for BD. Across all psychotic disorders, female gender and lifetime number of hospitalizations had strong independent associations with marriage, employment, and independent living.

Original languageEnglish
Pages (from-to)10-17
Number of pages8
JournalSCHIZOPHRENIA RESEARCH
Volume244
DOIs
Publication statusPublished - Jun 2022
Publication typeA1 Journal article-refereed

Keywords

  • Bipolar disorder
  • Level of functioning
  • Outcome
  • Psychotic depression
  • Schizoaffective disorder
  • Schizophrenia

Publication forum classification

  • Publication forum level 2

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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