Currently, ultrasound technology is routinely used for monitoring of the left side of the human heart during open-heart surgery. However, this method shows shortcomings in providing accurate information of the right ventricle and atrium. The aim of this paper is to demonstrate how Digital Image Correlation (DIC) can be used to monitor the functioning of the heart during open-heart surgery and potentially overcome some of the shortcomings of ultrasound methods. Being a contact-free method is a major asset from a practical implementation perspective of DIC. In this paper, we present the methodology of the experiment and some preliminary results of a study in which a DIC system was installed in an operating room and image sequences of the heart were taken at three stages of the surgery. We present a procedure for obtaining DIC measurements in this challenging setting, discuss how the data was extracted as well as how the measured values changed during the operation in the context of the surgical stages and interventions performed.