TY - GEN
T1 - Discovery and use of efficient biomarkers for objective disease state assessment in Alzheimer's disease
AU - Van Gils, Mark
AU - Koikkalainen, Juha
AU - Mattila, Jussi
AU - Herukka, Sanna Kaisa
AU - Lötjönen, Jyrki
AU - Soininen, Hilkka
PY - 2010
Y1 - 2010
N2 - Objective and early detection of Alzheimer's disease (AD) is a demanding problem requiring consideration of manymodal observations. Potentially, many features could be used to discern between people without AD and those at different stages of the disease. Such features include results from cognitive and memory tests, imaging (MRI, PET) results, cerebral spine fluid data, blood markers etc. However, in order to define an efficient and limited set of features that can be employed in classifiers requires mining of data from many patient cases. In this study we used two databases, ADNI and Kuopio LMCI, to investigate the relative importance of features and their combinations. Optimal feature combinations are to be used in a Clinical Decision Support System that is to be used in clinical AD diagnosis practice.
AB - Objective and early detection of Alzheimer's disease (AD) is a demanding problem requiring consideration of manymodal observations. Potentially, many features could be used to discern between people without AD and those at different stages of the disease. Such features include results from cognitive and memory tests, imaging (MRI, PET) results, cerebral spine fluid data, blood markers etc. However, in order to define an efficient and limited set of features that can be employed in classifiers requires mining of data from many patient cases. In this study we used two databases, ADNI and Kuopio LMCI, to investigate the relative importance of features and their combinations. Optimal feature combinations are to be used in a Clinical Decision Support System that is to be used in clinical AD diagnosis practice.
U2 - 10.1109/IEMBS.2010.5626311
DO - 10.1109/IEMBS.2010.5626311
M3 - Conference contribution
C2 - 21095977
AN - SCOPUS:78650842607
SN - 9781424441235
T3 - 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
SP - 2886
EP - 2889
BT - 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
T2 - 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Y2 - 31 August 2010 through 4 September 2010
ER -