Do rural second homes shape commensal microbiota of urban dwellers? A pilot study among urban elderly in Finland

Mika Saarenpää, Marja I. Roslund, Riikka Puhakka, Mira Grönroos, Anirudra Parajuli, Nan Hui, Noora Nurminen, Olli H. Laitinen, Heikki Hyöty, Ondrej Cinek, Aki Sinkkonen, the ADELE research group, Damiano Cerrone, Iida Mäkelä, Sami Oikarinen, Juho Rajaniemi, Laura Soininen, Yan Sun, Raisa Valve, Heli K. Vari

Research output: Contribution to journalArticleScientificpeer-review

Abstract

According to the hygiene and biodiversity hypotheses, increased hygiene levels and reduced contact with biodiversity can partially explain the high prevalence of immune-mediated diseases in developed countries. A disturbed commensal microbiota, especially in the gut, has been linked to multiple immune-mediated diseases. Previous studies imply that gut microbiota composition is associated with the everyday living environment and can be modified by increasing direct physical exposure to biodiverse materials. In this pilot study, the effects of rural-second-home tourism were investigated on the gut microbiota for the first time. Rural-second-home tourism, a popular form of outdoor recreation in Northern Europe, North America, and Russia, has the potential to alter the human microbiota by increasing exposure to nature and environmental microbes. The hypotheses were that the use of rural second homes is associated with differences in the gut microbiota and that the microbiota related to health benefits are more diverse or common among the rural-second-home users. Based on 16S rRNA Illumina MiSeq sequencing of stool samples from 10 urban elderly having access and 15 lacking access to a rural second home, the first hypothesis was supported: the use of rural second homes was found to be associated with lower gut microbiota diversity and RIG-I-like receptor signaling pathway levels. The second hypothesis was not supported: health-related microbiota were not more diverse or common among the second-home users. The current study encourages further research on the possible health outcomes or causes of the observed microbiological differences. Activities and diet during second-home visits, standard of equipment, surrounding environment, and length of the visits are all postulated to play a role in determining the effects of rural-second-home tourism on the gut microbiota.

Original languageEnglish
Article number3742
Number of pages19
JournalInternational journal of environmental research and public health
Volume18
Issue number7
DOIs
Publication statusPublished - Apr 2021
Publication typeA1 Journal article-refereed

Keywords

  • Cottage
  • Elderly
  • Fecal microbiota
  • Gut microbiota
  • Immune-mediated diseases
  • Outdoor recreation
  • Rural areas
  • Second home
  • Stool sample

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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