Domain-specific transfer learning in the automated scoring of tumor-stroma ratio from histopathological images of colorectal cancer

Liisa Petäinen, Juha P. Väyrynen, Pekka Ruusuvuori, Ilkka Pölönen, Sami Äyrämö, Teijo Kuopio

    Research output: Contribution to journalArticleScientificpeer-review

    3 Downloads (Pure)


    Tumor-stroma ratio (TSR) is a prognostic factor for many types of solid tumors. In this study, we propose a method for automated estimation of TSR from histopathological images of colorectal cancer. The method is based on convolutional neural networks which were trained to classify colorectal cancer tissue in hematoxylin-eosin stained samples into three classes: stroma, tumor and other. The models were trained using a data set that consists of 1343 whole slide images. Three different training setups were applied with a transfer learning approach using domain-specific data i.e. an external colorectal cancer histopathological data set. The three most accurate models were chosen as a classifier, TSR values were predicted and the results were compared to a visual TSR estimation made by a pathologist. The results suggest that classification accuracy does not improve when domain-specific data are used in the pre-training of the convolutional neural network models in the task at hand. Classification accuracy for stroma, tumor and other reached 96.1% on an independent test set. Among the three classes the best model gained the highest accuracy (99.3%) for class tumor. When TSR was predicted with the best model, the correlation between the predicted values and values estimated by an experienced pathologist was 0.57. Further research is needed to study associations between computationally predicted TSR values and other clinicopathological factors of colorectal cancer and the overall survival of the patients.

    Original languageEnglish
    Article numbere0286270
    Number of pages13
    JournalPLoS ONE
    Issue number5
    Publication statusPublished - May 2023
    Publication typeA1 Journal article-refereed

    Publication forum classification

    • Publication forum level 1

    ASJC Scopus subject areas

    • General


    Dive into the research topics of 'Domain-specific transfer learning in the automated scoring of tumor-stroma ratio from histopathological images of colorectal cancer'. Together they form a unique fingerprint.

    Cite this