Dynamic covalent crosslinked hyaluronic acid hydrogels and nanomaterials for biomedical applications

Shujiang Wang, Shima Tavakoli, Rohith Pavan Parvathaneni, Ganesh N Nawale, Oommen P Oommen, Jöns Hilborn, Oommen P Varghese

Research output: Contribution to journalReview Articlepeer-review


Hyaluronic acid (HA), one of the main components of the extracellular matrix (ECM), is extensively used in the design of hydrogels and nanoparticles for different biomedical applications due to its critical role in vivo, degradability by endogenous enzymes, and absence of immunogenicity. HA-based hydrogels and nanoparticles have been developed by utilizing different crosslinking chemistries. The development of such crosslinking chemistries indicates that even subtle differences in the structure of reactive groups or the procedure of crosslinking may have a profound impact on the intended mechanical, physical and biological outcomes. There are widespread examples of modified HA polymers that can form either covalently or physically crosslinked biomaterials. More recently, studies have been focused on dynamic covalent crosslinked HA-based biomaterials since these types of crosslinking allow the preparation of dynamic structures with the ability to form in situ, be injectable, and have self-healing properties. In this review, HA-based hydrogels and nanomaterials that are crosslinked by dynamic-covalent coupling (DCC) chemistry have been critically assessed.

Original languageEnglish
Pages (from-to)6399-6412
Number of pages14
JournalBiomaterials Science
Issue number22
Publication statusPublished - 2022
Publication typeA2 Review article in a scientific journal


  • Hydrogels/chemistry
  • Hyaluronic Acid/chemistry
  • Biocompatible Materials/chemistry
  • Extracellular Matrix
  • Nanostructures

Publication forum classification

  • Publication forum level 1


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