Dynamic Integrated Backscatter Detects Radiotherapy-induced Cardiac Changes Better than Strain Analysis: A Prospective Three-year Study

Suvi Sirkku Tuohinen, Tanja Skytta, Heini Huhtala, Vesa Virtanen, Pirkko Liisa Kellokumpu-Lehtinen, Pekka Raatikainen

Research output: Contribution to journalArticleScientificpeer-review

Abstract

BACKGROUND/AIM: Radiotherapy (RT) related myocardial changes were analyzed by deformation imaging echocardiography in this study. PATIENTS AND METHODS: Ninety-nine breast cancer patients were studied at baseline, after chemotherapy, after RT, and three years after RT (3Y). Eighty patients received RT only, and twenty patients had right-sided breast cancer. Echocardiography included cyclic variation of the integrated backscatter in the septum (sCV) and posterior wall (pCV), global longitudinal strain (GLS), and left ventricular ejection fraction (LVEF). RESULTS: In patients with left-sided breast cancer, sCV declined from 11.3±3.3 dB at baseline to 10.3±2.9 dB after RT (p=0.001). No changes were observed after chemotherapy (p=0.211) or in patients with right-sided breast cancer after RT (p=0.977). No other parameters declined after RT. The decline in sCV was independently associated with the left anterior descending coronary artery radiation dose (β=-0.290, p=0.020). CONCLUSION: In contrast to other parameters, sCV correlated with heart radiation dose.

Original languageEnglish
Pages (from-to)2507-2517
Number of pages11
JournalAnticancer research
Volume42
Issue number5
DOIs
Publication statusPublished - 2022
Publication typeA1 Journal article-refereed

Keywords

  • breast cancer
  • cyclic variation of the integrated backscatter
  • global longitudinal strain
  • myocardial imaging
  • Radiotherapy
  • speckle tracking echocardiography

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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