Dynamic Integrated Backscatter Detects Radiotherapy-induced Cardiac Changes Better than Strain Analysis: A Prospective Three-year Study

Suvi Sirkku Tuohinen; Tanja Skytta; Heini Huhtala; Vesa Virtanen; Pirkko Liisa Kellokumpu-Lehtinen; Pekka Raatikainen

doi:10.21873/anticanres.15729

Dynamic Integrated Backscatter Detects Radiotherapy-induced Cardiac Changes Better than Strain Analysis: A Prospective Three-year Study

Suvi Sirkku Tuohinen, Tanja Skytta, Heini Huhtala, Vesa Virtanen, Pirkko Liisa Kellokumpu-Lehtinen, Pekka Raatikainen

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Abstract

BACKGROUND/AIM: Radiotherapy (RT) related myocardial changes were analyzed by deformation imaging echocardiography in this study. PATIENTS AND METHODS: Ninety-nine breast cancer patients were studied at baseline, after chemotherapy, after RT, and three years after RT (3Y). Eighty patients received RT only, and twenty patients had right-sided breast cancer. Echocardiography included cyclic variation of the integrated backscatter in the septum (sCV) and posterior wall (pCV), global longitudinal strain (GLS), and left ventricular ejection fraction (LVEF). RESULTS: In patients with left-sided breast cancer, sCV declined from 11.3±3.3 dB at baseline to 10.3±2.9 dB after RT (p=0.001). No changes were observed after chemotherapy (p=0.211) or in patients with right-sided breast cancer after RT (p=0.977). No other parameters declined after RT. The decline in sCV was independently associated with the left anterior descending coronary artery radiation dose (β=-0.290, p=0.020). CONCLUSION: In contrast to other parameters, sCV correlated with heart radiation dose.

Original language	English
Pages (from-to)	2507-2517
Number of pages	11
Journal	Anticancer research
Volume	42
Issue number	5
DOIs	https://doi.org/10.21873/anticanres.15729
Publication status	Published - 2022
Publication type	A1 Journal article-refereed

Keywords

breast cancer
cyclic variation of the integrated backscatter
global longitudinal strain
myocardial imaging
Radiotherapy
speckle tracking echocardiography

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Publication forum level 1

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

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10.21873/anticanres.15729Licence: CC BY-NC-ND

2507.fullFinal published version, 3.15 MBLicence: CC BY-NC-ND

https://urn.fi/URN:NBN:fi:tuni-202205164941Licence: CC BY-NC-ND

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@article{195205b6ef124db0a3cd51a0b421e75d,

title = "Dynamic Integrated Backscatter Detects Radiotherapy-induced Cardiac Changes Better than Strain Analysis: A Prospective Three-year Study",

abstract = "BACKGROUND/AIM: Radiotherapy (RT) related myocardial changes were analyzed by deformation imaging echocardiography in this study. PATIENTS AND METHODS: Ninety-nine breast cancer patients were studied at baseline, after chemotherapy, after RT, and three years after RT (3Y). Eighty patients received RT only, and twenty patients had right-sided breast cancer. Echocardiography included cyclic variation of the integrated backscatter in the septum (sCV) and posterior wall (pCV), global longitudinal strain (GLS), and left ventricular ejection fraction (LVEF). RESULTS: In patients with left-sided breast cancer, sCV declined from 11.3±3.3 dB at baseline to 10.3±2.9 dB after RT (p=0.001). No changes were observed after chemotherapy (p=0.211) or in patients with right-sided breast cancer after RT (p=0.977). No other parameters declined after RT. The decline in sCV was independently associated with the left anterior descending coronary artery radiation dose (β=-0.290, p=0.020). CONCLUSION: In contrast to other parameters, sCV correlated with heart radiation dose.",

keywords = "breast cancer, cyclic variation of the integrated backscatter, global longitudinal strain, myocardial imaging, Radiotherapy, speckle tracking echocardiography",

author = "Tuohinen, {Suvi Sirkku} and Tanja Skytta and Heini Huhtala and Vesa Virtanen and Kellokumpu-Lehtinen, {Pirkko Liisa} and Pekka Raatikainen",

year = "2022",

doi = "10.21873/anticanres.15729",

language = "English",

volume = "42",

pages = "2507--2517",

number = "5",

}

TY - JOUR

T1 - Dynamic Integrated Backscatter Detects Radiotherapy-induced Cardiac Changes Better than Strain Analysis

T2 - A Prospective Three-year Study

AU - Tuohinen, Suvi Sirkku

AU - Skytta, Tanja

AU - Huhtala, Heini

AU - Virtanen, Vesa

AU - Kellokumpu-Lehtinen, Pirkko Liisa

AU - Raatikainen, Pekka

PY - 2022

Y1 - 2022

N2 - BACKGROUND/AIM: Radiotherapy (RT) related myocardial changes were analyzed by deformation imaging echocardiography in this study. PATIENTS AND METHODS: Ninety-nine breast cancer patients were studied at baseline, after chemotherapy, after RT, and three years after RT (3Y). Eighty patients received RT only, and twenty patients had right-sided breast cancer. Echocardiography included cyclic variation of the integrated backscatter in the septum (sCV) and posterior wall (pCV), global longitudinal strain (GLS), and left ventricular ejection fraction (LVEF). RESULTS: In patients with left-sided breast cancer, sCV declined from 11.3±3.3 dB at baseline to 10.3±2.9 dB after RT (p=0.001). No changes were observed after chemotherapy (p=0.211) or in patients with right-sided breast cancer after RT (p=0.977). No other parameters declined after RT. The decline in sCV was independently associated with the left anterior descending coronary artery radiation dose (β=-0.290, p=0.020). CONCLUSION: In contrast to other parameters, sCV correlated with heart radiation dose.

AB - BACKGROUND/AIM: Radiotherapy (RT) related myocardial changes were analyzed by deformation imaging echocardiography in this study. PATIENTS AND METHODS: Ninety-nine breast cancer patients were studied at baseline, after chemotherapy, after RT, and three years after RT (3Y). Eighty patients received RT only, and twenty patients had right-sided breast cancer. Echocardiography included cyclic variation of the integrated backscatter in the septum (sCV) and posterior wall (pCV), global longitudinal strain (GLS), and left ventricular ejection fraction (LVEF). RESULTS: In patients with left-sided breast cancer, sCV declined from 11.3±3.3 dB at baseline to 10.3±2.9 dB after RT (p=0.001). No changes were observed after chemotherapy (p=0.211) or in patients with right-sided breast cancer after RT (p=0.977). No other parameters declined after RT. The decline in sCV was independently associated with the left anterior descending coronary artery radiation dose (β=-0.290, p=0.020). CONCLUSION: In contrast to other parameters, sCV correlated with heart radiation dose.

KW - breast cancer

KW - cyclic variation of the integrated backscatter

KW - global longitudinal strain

KW - myocardial imaging

KW - Radiotherapy

KW - speckle tracking echocardiography

U2 - 10.21873/anticanres.15729

DO - 10.21873/anticanres.15729

M3 - Article

C2 - 35489739

AN - SCOPUS:85129166695

SN - 1791-7530

VL - 42

SP - 2507

EP - 2517

JO - Anticancer research

JF - Anticancer research

IS - 5

ER -

Dynamic Integrated Backscatter Detects Radiotherapy-induced Cardiac Changes Better than Strain Analysis: A Prospective Three-year Study

Abstract

Keywords

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ASJC Scopus subject areas

UN SDGs

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