Earlier life leisure-time physical activity in relation to age-related frailty syndrome

Laura Kolehmainen; Satu Havulinna; Tiia Ngandu; Timo Strandberg; Esko Levälahti; Jenni Lehtisalo; Riitta Antikainen; Elina Hietikko; Markku Peltonen; Auli Pölönen; Hilkka Soininen; Jaakko Tuomilehto; Tiina Laatikainen; Rainer Rauramaa; Miia Kivipelto; Jenni Kulmala

doi:10.1093/ageing/afaa132

Earlier life leisure-time physical activity in relation to age-related frailty syndrome

Laura Kolehmainen, Satu Havulinna, Tiia Ngandu, Timo Strandberg, Esko Levälahti, Jenni Lehtisalo, Riitta Antikainen, Elina Hietikko, Markku Peltonen, Auli Pölönen, Hilkka Soininen, Jaakko Tuomilehto, Tiina Laatikainen, Rainer Rauramaa, Miia Kivipelto, Jenni Kulmala

Department of Internal medicine

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

BACKGROUND: frailty syndrome is common amongst older people. Low physical activity is part of frailty, but long-term prospective studies investigating leisure-time physical activity (LTPA) during the life course as a predictor of frailty are still warranted. The aim of this study is to investigate whether earlier life LTPA predicts frailty in older age.

METHODS: the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) included older adults (aged 60-77 years) from the general population who were at increased risk of cognitive decline. Frailty was assessed for 1,137 participants at a baseline visit using a modified version of Fried's phenotype, including five criteria: weight loss, exhaustion, weakness, slowness and low physical activity. Self-reported data on earlier life LTPA were available from previous population-based studies (average follow-up time 13.6 years). A binomial logistic regression analysis was used to investigate the association between earlier life LTPA and pre-frailty/frailty in older age.

RESULTS: the prevalence of frailty and pre-frailty was 0.8% and 27.3%, respectively. In the analyses, pre-frail and frail groups were combined. People who had been physically very active (OR 0.37, 95% CI 0.23-0.60) or moderately active (OR 0.45, 95% CI 0.32-0.65) earlier in life had lower odds of becoming pre-frail/frail than individuals who had been sedentary.

CONCLUSIONS: frailty was rare in this relatively healthy study population, but almost a third of the participants were pre-frail. Earlier life LTPA was associated with lower levels of pre-frailty/frailty. The results highlight the importance of physical activity when aiming to promote healthy old age.

Original language	English
Pages (from-to)	161-168
Number of pages	8
Journal	AGE AND AGEING
Volume	50
Issue number	1
Early online date	17 Aug 2020
DOIs	https://doi.org/10.1093/ageing/afaa132
Publication status	Published - 8 Jan 2021
Publication type	A1 Journal article-refereed

Publication forum classification

Publication forum level 3

Access to Document

10.1093/ageing/afaa132

Cite this

Kolehmainen, L., Havulinna, S., Ngandu, T., Strandberg, T., Levälahti, E., Lehtisalo, J., Antikainen, R., Hietikko, E., Peltonen, M., Pölönen, A., Soininen, H., Tuomilehto, J., Laatikainen, T., Rauramaa, R., Kivipelto, M., & Kulmala, J. (2021). Earlier life leisure-time physical activity in relation to age-related frailty syndrome. AGE AND AGEING, 50(1), 161-168. https://doi.org/10.1093/ageing/afaa132

@article{834b2557965f464292a1a1ef834d70c6,

title = "Earlier life leisure-time physical activity in relation to age-related frailty syndrome",

abstract = "BACKGROUND: frailty syndrome is common amongst older people. Low physical activity is part of frailty, but long-term prospective studies investigating leisure-time physical activity (LTPA) during the life course as a predictor of frailty are still warranted. The aim of this study is to investigate whether earlier life LTPA predicts frailty in older age.METHODS: the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) included older adults (aged 60-77 years) from the general population who were at increased risk of cognitive decline. Frailty was assessed for 1,137 participants at a baseline visit using a modified version of Fried's phenotype, including five criteria: weight loss, exhaustion, weakness, slowness and low physical activity. Self-reported data on earlier life LTPA were available from previous population-based studies (average follow-up time 13.6 years). A binomial logistic regression analysis was used to investigate the association between earlier life LTPA and pre-frailty/frailty in older age.RESULTS: the prevalence of frailty and pre-frailty was 0.8% and 27.3%, respectively. In the analyses, pre-frail and frail groups were combined. People who had been physically very active (OR 0.37, 95% CI 0.23-0.60) or moderately active (OR 0.45, 95% CI 0.32-0.65) earlier in life had lower odds of becoming pre-frail/frail than individuals who had been sedentary.CONCLUSIONS: frailty was rare in this relatively healthy study population, but almost a third of the participants were pre-frail. Earlier life LTPA was associated with lower levels of pre-frailty/frailty. The results highlight the importance of physical activity when aiming to promote healthy old age.",

author = "Laura Kolehmainen and Satu Havulinna and Tiia Ngandu and Timo Strandberg and Esko Lev{\"a}lahti and Jenni Lehtisalo and Riitta Antikainen and Elina Hietikko and Markku Peltonen and Auli P{\"o}l{\"o}nen and Hilkka Soininen and Jaakko Tuomilehto and Tiina Laatikainen and Rainer Rauramaa and Miia Kivipelto and Jenni Kulmala",

note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.",

year = "2021",

month = jan,

day = "8",

doi = "10.1093/ageing/afaa132",

language = "English",

volume = "50",

pages = "161--168",

journal = "AGE AND AGEING",

issn = "0002-0729",

publisher = "Oxford University Press",

number = "1",

}

Kolehmainen, L, Havulinna, S, Ngandu, T, Strandberg, T, Levälahti, E, Lehtisalo, J, Antikainen, R, Hietikko, E, Peltonen, M, Pölönen, A, Soininen, H, Tuomilehto, J, Laatikainen, T, Rauramaa, R, Kivipelto, M & Kulmala, J 2021, 'Earlier life leisure-time physical activity in relation to age-related frailty syndrome', AGE AND AGEING, vol. 50, no. 1, pp. 161-168. https://doi.org/10.1093/ageing/afaa132

TY - JOUR

T1 - Earlier life leisure-time physical activity in relation to age-related frailty syndrome

AU - Kolehmainen, Laura

AU - Havulinna, Satu

AU - Ngandu, Tiia

AU - Strandberg, Timo

AU - Levälahti, Esko

AU - Lehtisalo, Jenni

AU - Antikainen, Riitta

AU - Hietikko, Elina

AU - Peltonen, Markku

AU - Pölönen, Auli

AU - Soininen, Hilkka

AU - Tuomilehto, Jaakko

AU - Laatikainen, Tiina

AU - Rauramaa, Rainer

AU - Kivipelto, Miia

AU - Kulmala, Jenni

PY - 2021/1/8

Y1 - 2021/1/8

N2 - BACKGROUND: frailty syndrome is common amongst older people. Low physical activity is part of frailty, but long-term prospective studies investigating leisure-time physical activity (LTPA) during the life course as a predictor of frailty are still warranted. The aim of this study is to investigate whether earlier life LTPA predicts frailty in older age.METHODS: the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) included older adults (aged 60-77 years) from the general population who were at increased risk of cognitive decline. Frailty was assessed for 1,137 participants at a baseline visit using a modified version of Fried's phenotype, including five criteria: weight loss, exhaustion, weakness, slowness and low physical activity. Self-reported data on earlier life LTPA were available from previous population-based studies (average follow-up time 13.6 years). A binomial logistic regression analysis was used to investigate the association between earlier life LTPA and pre-frailty/frailty in older age.RESULTS: the prevalence of frailty and pre-frailty was 0.8% and 27.3%, respectively. In the analyses, pre-frail and frail groups were combined. People who had been physically very active (OR 0.37, 95% CI 0.23-0.60) or moderately active (OR 0.45, 95% CI 0.32-0.65) earlier in life had lower odds of becoming pre-frail/frail than individuals who had been sedentary.CONCLUSIONS: frailty was rare in this relatively healthy study population, but almost a third of the participants were pre-frail. Earlier life LTPA was associated with lower levels of pre-frailty/frailty. The results highlight the importance of physical activity when aiming to promote healthy old age.

AB - BACKGROUND: frailty syndrome is common amongst older people. Low physical activity is part of frailty, but long-term prospective studies investigating leisure-time physical activity (LTPA) during the life course as a predictor of frailty are still warranted. The aim of this study is to investigate whether earlier life LTPA predicts frailty in older age.METHODS: the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) included older adults (aged 60-77 years) from the general population who were at increased risk of cognitive decline. Frailty was assessed for 1,137 participants at a baseline visit using a modified version of Fried's phenotype, including five criteria: weight loss, exhaustion, weakness, slowness and low physical activity. Self-reported data on earlier life LTPA were available from previous population-based studies (average follow-up time 13.6 years). A binomial logistic regression analysis was used to investigate the association between earlier life LTPA and pre-frailty/frailty in older age.RESULTS: the prevalence of frailty and pre-frailty was 0.8% and 27.3%, respectively. In the analyses, pre-frail and frail groups were combined. People who had been physically very active (OR 0.37, 95% CI 0.23-0.60) or moderately active (OR 0.45, 95% CI 0.32-0.65) earlier in life had lower odds of becoming pre-frail/frail than individuals who had been sedentary.CONCLUSIONS: frailty was rare in this relatively healthy study population, but almost a third of the participants were pre-frail. Earlier life LTPA was associated with lower levels of pre-frailty/frailty. The results highlight the importance of physical activity when aiming to promote healthy old age.

U2 - 10.1093/ageing/afaa132

DO - 10.1093/ageing/afaa132

M3 - Article

C2 - 32808971

VL - 50

SP - 161

EP - 168

JO - AGE AND AGEING

JF - AGE AND AGEING

SN - 0002-0729

IS - 1

ER -

Earlier life leisure-time physical activity in relation to age-related frailty syndrome

Abstract

Publication forum classification

Access to Document

Fingerprint

Cite this