Early-pregnancy BMI, maternal gestational weight gain, and asthma and allergic diseases in children

Vincent Ojwang; Bright I. Nwaru; Hanna-Mari Takkinen; Heli Tapanainen; Minna Kaila; Suvi Ahonen; Onni Niemelä; Anna Maija Haapala; Jorma Ilonen; Jorma Toppari; Heikki Hyöty; Riitta Veijola; Mikael Knip; Suvi M. Virtanen

doi:10.1111/pai.14240

Early-pregnancy BMI, maternal gestational weight gain, and asthma and allergic diseases in children

Vincent Ojwang^*
, Bright I. Nwaru
, Hanna-Mari Takkinen
, Heli Tapanainen
, Minna Kaila
, Suvi Ahonen
, Onni Niemelä
, Anna Maija Haapala
, Jorma Ilonen
, Jorma Toppari
, Heikki Hyöty
, Riitta Veijola
, Mikael Knip
, Suvi M. Virtanen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

4 Citations (Scopus)

12 Downloads (Pure)

Abstract

Background: Association of early pregnancy body mass index (BMI) and maternal gestational weight gain (GWG), and asthma and allergic disease in children is unclear. Methods: We analyzed data from 3176 mother–child pairs in a prospective birth cohort study. Maternal anthropometric measurements in the first and last antenatal clinic visits were obtained through post-delivery questionnaires to calculate early pregnancy BMI and maternal GWG. Asthma and allergic diseases in children by the age of 5 years was assessed using a validated questionnaire. Furthermore, serum samples were analyzed for IgE antibodies to eight allergens. We applied Cox proportional hazards and logistic regression analyses to estimate the association of early pregnancy BMI and maternal GWG (as continuous variables and categorized into quarters), and asthma, atopic eczema, atopic sensitization, and allergic rhinitis in children. Results: Neither early pregnancy BMI nor maternal GWG was associated with asthma and allergic disease in children when analyzed as continuous variables. However, compared to the first quarter of GWG (a rate <0.32 kg/week), mothers in the third quarter (rate 0.42–0.52 kg/week) had children with significantly higher odds of developing atopic eczema (adjusted OR 1.49, 95% CI [1.13–1.96]) by 5 years of age. Conclusion: Association of early pregnancy BMI and maternal GWG, and asthma and allergic disease in children, is inconsistent. High maternal GWG may be associated with increased odds of atopic eczema.

Original language	English
Article number	e14240
Number of pages	10
Journal	Pediatric Allergy and Immunology
Volume	35
Issue number	9
DOIs	https://doi.org/10.1111/pai.14240
Publication status	Published - Sept 2024
Publication type	A1 Journal article-refereed

Funding

The study was supported by funding from Research Council of Finland (grants 63,672, 68,292, 79,685, 79,686, 80,846, 114,666, 126,813, 129,492, 139,391, 201,988, 210,632, 250,114, 276,475, 308,066, 339,922); the Prevaller Consortium; the Foundation for Pediatric Research; the Tampere Tuberculosis Foundation; the Juho Vainio Foundation; the Yrjo Jahnsson Foundation; European Foundation for the Study of Diabetes; Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital (grants 9E082, 9F089, 9G087, 9H092, 9\u2009J147, 9\u2009K149, 9\u2009L042, 9\u2009L117, 9\u2009M036, 9\u2009M114, 9\u2009N086, 9P057, 9R055, 9S074, 9\u2009T072, 9\u2009U065, 9\u2009V072, 9X062, 9AA084, 9AB083); the Juvenile Diabetes Research Foundation (grants 4\u20131998\u2010274, 4\u20131999\u2010731, 4\u20132001\u2010435, 1\u2010SRA\u20102016\u2010342\u2010M\u2010R, 1\u2010SRA\u20102019\u2010732\u2010M\u2010B, and 3\u2010SRA\u20102020\u2010955\u2010S\u2010B); the Novo Nordisk Foundation; the European Union Biomed 2 Program (BMH4\u2010CT98\u20103314); the European Union Horizon 2020 Research and Innovation Programme (grant 874,864 HEDIMED).

Funders	Funder number
Tampereen tuberkuloosisäätiö
Lastentautien tutkimussäätiö
Juho Vainion Säätiö
Novo Nordisk Fonden
Yrjö Jahnssonin säätiö
European Lung Foundation	9AA084, 9G087, 9X062, 9F089, 9AB083, 9 N086, 9 K149, 9 J147, 9 U065, 9P057, 9S074, 9E082, 9H092, 9 V072, 9R055
Strategic Research Council at the Research Council of Finland	129,492, 139,391, 201,988, 276,475, 63,672, 68,292, 80,846, 308,066, 126,813, 250,114, 210,632, 79,686, 339,922, 79,685, 114,666
Strategic Research Council at the Research Council of Finland
Horizon 2020	874,864 HEDIMED
Horizon 2020
Juvenile Diabetes Research Foundation International	1‐SRA‐2019‐732‐M‐B, 4–1998‐274, 3‐SRA‐2020‐955‐S‐B
Juvenile Diabetes Research Foundation International
European Union Biomed 2 Program	BMH4‐CT98‐3314

Keywords

allergic rhinitis
asthma
atopic eczema
atopic sensitization
BMI
children
early pregnancy
gestational weight gain

Publication forum classification

Publication forum level 2

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Immunology and Allergy
Immunology

Access to Document

10.1111/pai.14240Licence: CC BY

Pediatric Allergy Immunology - 2024 - Ojwang’ - Early‐pregnancy BMI maternal gestational weight gain and asthma andFinal published version, 400 KBLicence: CC BY

https://urn.fi/URN:NBN:fi:tuni-202410039077Licence: CC BY

Cite this

Ojwang, V., Nwaru, B. I., Takkinen, H.-M., Tapanainen, H., Kaila, M., Ahonen, S., Niemelä, O., Haapala, A. M., Ilonen, J., Toppari, J., Hyöty, H., Veijola, R., Knip, M., & Virtanen, S. M. (2024). Early-pregnancy BMI, maternal gestational weight gain, and asthma and allergic diseases in children. Pediatric Allergy and Immunology, 35(9), Article e14240. https://doi.org/10.1111/pai.14240

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title = "Early-pregnancy BMI, maternal gestational weight gain, and asthma and allergic diseases in children",

abstract = "Background: Association of early pregnancy body mass index (BMI) and maternal gestational weight gain (GWG), and asthma and allergic disease in children is unclear. Methods: We analyzed data from 3176 mother–child pairs in a prospective birth cohort study. Maternal anthropometric measurements in the first and last antenatal clinic visits were obtained through post-delivery questionnaires to calculate early pregnancy BMI and maternal GWG. Asthma and allergic diseases in children by the age of 5 years was assessed using a validated questionnaire. Furthermore, serum samples were analyzed for IgE antibodies to eight allergens. We applied Cox proportional hazards and logistic regression analyses to estimate the association of early pregnancy BMI and maternal GWG (as continuous variables and categorized into quarters), and asthma, atopic eczema, atopic sensitization, and allergic rhinitis in children. Results: Neither early pregnancy BMI nor maternal GWG was associated with asthma and allergic disease in children when analyzed as continuous variables. However, compared to the first quarter of GWG (a rate <0.32 kg/week), mothers in the third quarter (rate 0.42–0.52 kg/week) had children with significantly higher odds of developing atopic eczema (adjusted OR 1.49, 95\% CI [1.13–1.96]) by 5 years of age. Conclusion: Association of early pregnancy BMI and maternal GWG, and asthma and allergic disease in children, is inconsistent. High maternal GWG may be associated with increased odds of atopic eczema.",

keywords = "allergic rhinitis, asthma, atopic eczema, atopic sensitization, BMI, children, early pregnancy, gestational weight gain",

author = "Vincent Ojwang and Nwaru, \{Bright I.\} and Hanna-Mari Takkinen and Heli Tapanainen and Minna Kaila and Suvi Ahonen and Onni Niemel{\"a} and Haapala, \{Anna Maija\} and Jorma Ilonen and Jorma Toppari and Heikki Hy{\"o}ty and Riitta Veijola and Mikael Knip and Virtanen, \{Suvi M.\}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley \& Sons Ltd.",

year = "2024",

month = sep,

doi = "10.1111/pai.14240",

language = "English",

volume = "35",

journal = "Pediatric Allergy and Immunology",

issn = "0905-6157",

publisher = "Blackwell Munksgaard",

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TY - JOUR

T1 - Early-pregnancy BMI, maternal gestational weight gain, and asthma and allergic diseases in children

AU - Ojwang, Vincent

AU - Nwaru, Bright I.

AU - Takkinen, Hanna-Mari

AU - Tapanainen, Heli

AU - Kaila, Minna

AU - Ahonen, Suvi

AU - Niemelä, Onni

AU - Haapala, Anna Maija

AU - Ilonen, Jorma

AU - Toppari, Jorma

AU - Hyöty, Heikki

AU - Veijola, Riitta

AU - Knip, Mikael

AU - Virtanen, Suvi M.

PY - 2024/9

Y1 - 2024/9

N2 - Background: Association of early pregnancy body mass index (BMI) and maternal gestational weight gain (GWG), and asthma and allergic disease in children is unclear. Methods: We analyzed data from 3176 mother–child pairs in a prospective birth cohort study. Maternal anthropometric measurements in the first and last antenatal clinic visits were obtained through post-delivery questionnaires to calculate early pregnancy BMI and maternal GWG. Asthma and allergic diseases in children by the age of 5 years was assessed using a validated questionnaire. Furthermore, serum samples were analyzed for IgE antibodies to eight allergens. We applied Cox proportional hazards and logistic regression analyses to estimate the association of early pregnancy BMI and maternal GWG (as continuous variables and categorized into quarters), and asthma, atopic eczema, atopic sensitization, and allergic rhinitis in children. Results: Neither early pregnancy BMI nor maternal GWG was associated with asthma and allergic disease in children when analyzed as continuous variables. However, compared to the first quarter of GWG (a rate <0.32 kg/week), mothers in the third quarter (rate 0.42–0.52 kg/week) had children with significantly higher odds of developing atopic eczema (adjusted OR 1.49, 95% CI [1.13–1.96]) by 5 years of age. Conclusion: Association of early pregnancy BMI and maternal GWG, and asthma and allergic disease in children, is inconsistent. High maternal GWG may be associated with increased odds of atopic eczema.

AB - Background: Association of early pregnancy body mass index (BMI) and maternal gestational weight gain (GWG), and asthma and allergic disease in children is unclear. Methods: We analyzed data from 3176 mother–child pairs in a prospective birth cohort study. Maternal anthropometric measurements in the first and last antenatal clinic visits were obtained through post-delivery questionnaires to calculate early pregnancy BMI and maternal GWG. Asthma and allergic diseases in children by the age of 5 years was assessed using a validated questionnaire. Furthermore, serum samples were analyzed for IgE antibodies to eight allergens. We applied Cox proportional hazards and logistic regression analyses to estimate the association of early pregnancy BMI and maternal GWG (as continuous variables and categorized into quarters), and asthma, atopic eczema, atopic sensitization, and allergic rhinitis in children. Results: Neither early pregnancy BMI nor maternal GWG was associated with asthma and allergic disease in children when analyzed as continuous variables. However, compared to the first quarter of GWG (a rate <0.32 kg/week), mothers in the third quarter (rate 0.42–0.52 kg/week) had children with significantly higher odds of developing atopic eczema (adjusted OR 1.49, 95% CI [1.13–1.96]) by 5 years of age. Conclusion: Association of early pregnancy BMI and maternal GWG, and asthma and allergic disease in children, is inconsistent. High maternal GWG may be associated with increased odds of atopic eczema.

KW - allergic rhinitis

KW - asthma

KW - atopic eczema

KW - atopic sensitization

KW - BMI

KW - children

KW - early pregnancy

KW - gestational weight gain

U2 - 10.1111/pai.14240

DO - 10.1111/pai.14240

M3 - Article

AN - SCOPUS:85204063455

SN - 0905-6157

VL - 35

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

IS - 9

M1 - e14240

ER -

Early-pregnancy BMI, maternal gestational weight gain, and asthma and allergic diseases in children

Abstract

Funding

Keywords

Publication forum classification

ASJC Scopus subject areas

Access to Document

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Cite this