Educational history is an independent predictor of cognitive deficits and long-term survival in postacute patients with mild to moderate ischemic stroke

Johanna Ojala-Oksala; Hanna Jokinen; Valtteri Kopsi; Kalevi Lehtonen; Liisa Luukkonen; Antti Paukkunen; Lotte Seeck; Susanna Melkas; Tarja Pohjasvaara; Pekka Karhunen; Marja Hietanen; Timo Erkinjuntti; Niku Oksala

doi:10.1161/strokeaha.112.667618

Educational history is an independent predictor of cognitive deficits and long-term survival in postacute patients with mild to moderate ischemic stroke

Johanna Ojala-Oksala, Hanna Jokinen, Valtteri Kopsi, Kalevi Lehtonen, Liisa Luukkonen, Antti Paukkunen, Lotte Seeck, Susanna Melkas, Tarja Pohjasvaara, Pekka Karhunen, Marja Hietanen, Timo Erkinjuntti, Niku Oksala

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Abstract

Background and Purpose-Poststroke cognitive decline and white matter lesions (WML) are related to poor poststroke survival. Whether cognitive reserve as reflected by educational history associates with cognitive decline, recurrent strokes, and poststroke mortality independent of WML is not known. Methods-A total of 486 consecutive acute mild/moderate ischemic stroke patients subjected to comprehensive neuropsychological assessment (n=409) and magnetic resonance imaging (n=395) 3 months poststroke were included in the study and followed-up for up to 12 years. Odds ratios (OR) for logistic and hazard ratios for Cox regression analyses are reported (OR and hazard ratio ≤1 indicates a beneficial effect). Results-Long educational history (per tertile) was associated with lower frequency of executive dysfunction in models adjusted for age, sex, marital status, and stroke severity (OR, 0.75: P

Original language	English
Pages (from-to)	2931-2935
Number of pages	5
Journal	STROKE
Volume	43
Issue number	11
DOIs	https://doi.org/10.1161/strokeaha.112.667618
Publication status	Published - 2012
Publication type	A1 Journal article-refereed

Keywords

education
stroke
survival

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10.1161/strokeaha.112.667618

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Ojala-Oksala, J., Jokinen, H., Kopsi, V., Lehtonen, K., Luukkonen, L., Paukkunen, A., Seeck, L., Melkas, S., Pohjasvaara, T., Karhunen, P., Hietanen, M., Erkinjuntti, T., & Oksala, N. (2012). Educational history is an independent predictor of cognitive deficits and long-term survival in postacute patients with mild to moderate ischemic stroke. STROKE, 43(11), 2931-2935. https://doi.org/10.1161/strokeaha.112.667618

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title = "Educational history is an independent predictor of cognitive deficits and long-term survival in postacute patients with mild to moderate ischemic stroke",

abstract = "Background and Purpose-Poststroke cognitive decline and white matter lesions (WML) are related to poor poststroke survival. Whether cognitive reserve as reflected by educational history associates with cognitive decline, recurrent strokes, and poststroke mortality independent of WML is not known. Methods-A total of 486 consecutive acute mild/moderate ischemic stroke patients subjected to comprehensive neuropsychological assessment (n=409) and magnetic resonance imaging (n=395) 3 months poststroke were included in the study and followed-up for up to 12 years. Odds ratios (OR) for logistic and hazard ratios for Cox regression analyses are reported (OR and hazard ratio ≤1 indicates a beneficial effect). Results-Long educational history (per tertile) was associated with lower frequency of executive dysfunction in models adjusted for age, sex, marital status, and stroke severity (OR, 0.75: P",

keywords = "education, stroke, survival, education, stroke, survival",

author = "Johanna Ojala-Oksala and Hanna Jokinen and Valtteri Kopsi and Kalevi Lehtonen and Liisa Luukkonen and Antti Paukkunen and Lotte Seeck and Susanna Melkas and Tarja Pohjasvaara and Pekka Karhunen and Marja Hietanen and Timo Erkinjuntti and Niku Oksala",

year = "2012",

doi = "10.1161/strokeaha.112.667618",

language = "English",

volume = "43",

pages = "2931--2935",

number = "11",

}

Ojala-Oksala, J, Jokinen, H, Kopsi, V, Lehtonen, K, Luukkonen, L, Paukkunen, A, Seeck, L, Melkas, S, Pohjasvaara, T, Karhunen, P, Hietanen, M, Erkinjuntti, T & Oksala, N 2012, 'Educational history is an independent predictor of cognitive deficits and long-term survival in postacute patients with mild to moderate ischemic stroke', STROKE, vol. 43, no. 11, pp. 2931-2935. https://doi.org/10.1161/strokeaha.112.667618

TY - JOUR

T1 - Educational history is an independent predictor of cognitive deficits and long-term survival in postacute patients with mild to moderate ischemic stroke

AU - Ojala-Oksala, Johanna

AU - Jokinen, Hanna

AU - Kopsi, Valtteri

AU - Lehtonen, Kalevi

AU - Luukkonen, Liisa

AU - Paukkunen, Antti

AU - Seeck, Lotte

AU - Melkas, Susanna

AU - Pohjasvaara, Tarja

AU - Karhunen, Pekka

AU - Hietanen, Marja

AU - Erkinjuntti, Timo

AU - Oksala, Niku

PY - 2012

Y1 - 2012

N2 - Background and Purpose-Poststroke cognitive decline and white matter lesions (WML) are related to poor poststroke survival. Whether cognitive reserve as reflected by educational history associates with cognitive decline, recurrent strokes, and poststroke mortality independent of WML is not known. Methods-A total of 486 consecutive acute mild/moderate ischemic stroke patients subjected to comprehensive neuropsychological assessment (n=409) and magnetic resonance imaging (n=395) 3 months poststroke were included in the study and followed-up for up to 12 years. Odds ratios (OR) for logistic and hazard ratios for Cox regression analyses are reported (OR and hazard ratio ≤1 indicates a beneficial effect). Results-Long educational history (per tertile) was associated with lower frequency of executive dysfunction in models adjusted for age, sex, marital status, and stroke severity (OR, 0.75: P

AB - Background and Purpose-Poststroke cognitive decline and white matter lesions (WML) are related to poor poststroke survival. Whether cognitive reserve as reflected by educational history associates with cognitive decline, recurrent strokes, and poststroke mortality independent of WML is not known. Methods-A total of 486 consecutive acute mild/moderate ischemic stroke patients subjected to comprehensive neuropsychological assessment (n=409) and magnetic resonance imaging (n=395) 3 months poststroke were included in the study and followed-up for up to 12 years. Odds ratios (OR) for logistic and hazard ratios for Cox regression analyses are reported (OR and hazard ratio ≤1 indicates a beneficial effect). Results-Long educational history (per tertile) was associated with lower frequency of executive dysfunction in models adjusted for age, sex, marital status, and stroke severity (OR, 0.75: P

KW - education

KW - stroke

KW - survival

KW - education

KW - stroke

KW - survival

U2 - 10.1161/strokeaha.112.667618

DO - 10.1161/strokeaha.112.667618

M3 - Article

AN - SCOPUS:84868201364

VL - 43

SP - 2931

EP - 2935

IS - 11

ER -

Educational history is an independent predictor of cognitive deficits and long-term survival in postacute patients with mild to moderate ischemic stroke

Abstract

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