TY - JOUR
T1 - Effect of lipid-based nutrient supplements on morbidity among children with stunting
T2 - secondary analysis of a randomized trial in Uganda
AU - Mutumba, Rolland
AU - Mbabazi, Joseph
AU - Pesu, Hannah
AU - Lewis, Jack I.
AU - Mølgaard, Christian
AU - Ritz, Christian
AU - Olsen, Mette F.
AU - Briend, Andre
AU - Nabukeera-Barungi, Nicolette
AU - Wells, Jonathan C.
AU - Friis, Henrik
AU - Grenov, Benedikte
AU - Mupere, Ezekiel
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025
Y1 - 2025
N2 - Background: Children with stunting are at risk of infections. We assessed the effect of lipid-based nutrient supplement (LNS) on morbidity in children with stunting. Methods: This was a secondary analysis of a randomized, 2×2 factorial trial among 12–59 months-old, stunted children in Uganda. Children were randomized to LNS containing milk or soy protein and whey permeate or maltodextrin, or no supplementation, for 12 weeks. The outcomes were caregiver-reported morbidity after 2, 4, 8 and 12 weeks, serum C-reactive protein (S-CRP), α1-acid glycoprotein (S-AGP), and phase-angle (PhA) by bioimpedance. Results: Of 750 children, mean (SD) age was 32.0 (11.7) months, 55% (n = 412) were male. LNS increased diarrhoea prevalence (18.1% vs 7.3%, P = 0.001) during the first two weeks, but not thereafter. There was no effect of LNS on cough or fever. LNS resulted in greater decline in S-AGP (−0.10 g/L, 95% CI: −0.17, −0.03, P = 0.003) but not S-CRP (25%, 95% CI: −11, 74, P = 0.193), and greater increase in PhA (0.10 degrees, 95% CI: 0.01, 0.18, P = 0.030), explained by greater fat-free mass. Milk compared to soy protein in LNS resulted in higher PhA (0.10 degrees, 95% CI: 0.02, 0.17, P = 0.013), not explained by fat-free mass. Conclusion: LNS supplementation in children with stunting had no effect on morbidity but resulted in a small reduction in sub-acute systemic inflammation. The possible effect of LNS supplementation on inflammation in stunted children requires further evaluation. (www.isrctn.com: ISRCTN13093195).
AB - Background: Children with stunting are at risk of infections. We assessed the effect of lipid-based nutrient supplement (LNS) on morbidity in children with stunting. Methods: This was a secondary analysis of a randomized, 2×2 factorial trial among 12–59 months-old, stunted children in Uganda. Children were randomized to LNS containing milk or soy protein and whey permeate or maltodextrin, or no supplementation, for 12 weeks. The outcomes were caregiver-reported morbidity after 2, 4, 8 and 12 weeks, serum C-reactive protein (S-CRP), α1-acid glycoprotein (S-AGP), and phase-angle (PhA) by bioimpedance. Results: Of 750 children, mean (SD) age was 32.0 (11.7) months, 55% (n = 412) were male. LNS increased diarrhoea prevalence (18.1% vs 7.3%, P = 0.001) during the first two weeks, but not thereafter. There was no effect of LNS on cough or fever. LNS resulted in greater decline in S-AGP (−0.10 g/L, 95% CI: −0.17, −0.03, P = 0.003) but not S-CRP (25%, 95% CI: −11, 74, P = 0.193), and greater increase in PhA (0.10 degrees, 95% CI: 0.01, 0.18, P = 0.030), explained by greater fat-free mass. Milk compared to soy protein in LNS resulted in higher PhA (0.10 degrees, 95% CI: 0.02, 0.17, P = 0.013), not explained by fat-free mass. Conclusion: LNS supplementation in children with stunting had no effect on morbidity but resulted in a small reduction in sub-acute systemic inflammation. The possible effect of LNS supplementation on inflammation in stunted children requires further evaluation. (www.isrctn.com: ISRCTN13093195).
U2 - 10.1038/s41430-025-01611-3
DO - 10.1038/s41430-025-01611-3
M3 - Article
AN - SCOPUS:105001515242
SN - 0954-3007
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
M1 - 104938
ER -
