Effect of remdesivir post hospitalization for COVID-19 infection from the randomized SOLIDARITY Finland trial

Solidarity Finland Investigators, Olli P.O. Nevalainen, Saana Horstia, Sanna Laakkonen, Jarno Rutanen, Jussi M.J. Mustonen, Ilkka E.J. Kalliala, Hanna Ansakorpi, Hanna Riikka Kreivi, Pauliina Kuutti, Juuso Paajanen, Seppo Parkkila, Erja Leena Paukkeri, Markus Perola, Negar Pourjamal, Andreas Renner, Tuomas Rosberg, Taija Rutanen, Joni Savolainen, Jari K. HaukkaGordon H. Guyatt, Kari A.O. Tikkinen

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We report the first long-term follow-up of a randomized trial (NCT04978259) addressing the effects of remdesivir on recovery (primary outcome) and other patient-important outcomes one year after hospitalization resulting from COVID-19. Of the 208 patients recruited from 11 Finnish hospitals, 198 survived, of whom 181 (92%) completed follow-up. At one year, self-reported recovery occurred in 85% in remdesivir and 86% in standard of care (SoC) (RR 0.94, 95% CI 0.47-1.90). We infer no convincing difference between remdesivir and SoC in quality of life or symptom outcomes (p > 0.05). Of the 21 potential long-COVID symptoms, patients reported moderate/major bother from fatigue (26%), joint pain (22%), and problems with memory (19%) and attention/concentration (18%). In conclusion, after a one-year follow-up of hospitalized patients, one in six reported they had not recovered well from COVID-19. Our results provide no convincing evidence of remdesivir benefit, but wide confidence intervals included possible benefit and harm.

Original languageEnglish
Article number6152
Number of pages6
JournalNature Communications
Publication statusPublished - Oct 2022
Publication typeA1 Journal article-refereed

Publication forum classification

  • Publication forum level 3

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • General
  • Physics and Astronomy(all)


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