Effects of maternal lifestyle interventions on child neurobehavioral development: Follow-up of randomized controlled trials

Malou D. Menting; Cornelieke van de Beek; Kristiina Rono; Annemieke Hoek; Henk Groen; Rebecca C. Painter; Polina Girchenko; Marius Lahti-Pulkkinen; Saila B. Koivusalo; Katri Räikkönen; Johan G. Eriksson; Tessa J. Roseboom; Kati Heinonen

doi:10.1111/sjop.12575

Effects of maternal lifestyle interventions on child neurobehavioral development: Follow-up of randomized controlled trials

Malou D. Menting^*
, Cornelieke van de Beek
, Kristiina Rono
, Annemieke Hoek
, Henk Groen
, Rebecca C. Painter
, Polina Girchenko
, Marius Lahti-Pulkkinen
, Saila B. Koivusalo
, Katri Räikkönen
, Johan G. Eriksson
, Tessa J. Roseboom
, Kati Heinonen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

7 Citations (Scopus)

Abstract

Obesity is a major public health problem. Children of women who were obese before or during pregnancy are at increased risk for neurobehavioral developmental problems. Whether a maternal lifestyle intervention conducted before and during pregnancy in obese women affects child neurobehavioral development is unknown. This study reports on the follow-up of a subsample of two randomized controlled trials, the Finnish RADIEL (n = 216) and Dutch LIFEstyle (n = 305) trial. Women with a pre-pregnancy BMI ≥29 kg/m² wishing to conceive or who were already pregnant (<20 weeks) were allocated to a lifestyle intervention or to care as usual. Child neurodevelopment was measured with the Ages and Stages Questionnaire and child behavioral problems were measured with the Childhood Behavior Checklist (RADIEL) or the Strengths and Difficulties Questionnaire (LIFEstyle) at age 3-6 years. We used linear and binary logistic regression analyses to assess the effects of the lifestyle interventions on children's neurobehavioral developmental scores. Follow-up data was available from 161(38%) RADIEL and 96(32%) LIFEstyle children. Child neurodevelopmental scores did not differ significantly between children in the intervention and the control group (RADIEL:median = 275 vs. 280; LIFEstyle:median = 270 vs 267). Child behavioral problem scores did not differ significantly between children in the intervention and the control group (RADIEL:median = 22 vs. 21; LIFEstyle:median = 8 vs. 8). We did not observe considerable effects of the lifestyle interventions before or during pregnancy in obese women on child neurobehavioral development. With our sample sizes, we were not able to detect subtle differences in neurobehavioral development however.

Original language	English
Pages (from-to)	548-558
Number of pages	11
Journal	Scandinavian Journal of Psychology
Volume	60
Issue number	6
DOIs	https://doi.org/10.1111/sjop.12575
Publication status	Published - 1 Dec 2019
Publication type	A1 Journal article-refereed

Funding

This study was conducted with the support of a grant from the Dutch Heart Foundation (grant number 2013T085); a grant from the European Union's Horizon 2020 research and innovation program DynaHealth (grant number: 633595); grants from the Academy of Finland (grant number 1284859 and 12848591); with the support from the Academy of Finland (grant number 12853241) and with the support of the University of Helsinki. The department of Obstetrics and Gynecology UMCG receives an unrestricted educational grant from Ferring Pharmaceutical BV The Netherlands. The authors have no other financial relationships relevant to this article to disclose. This study was conducted with the support of a grant from the Dutch Heart Foundation (grant number 2013T085); a grant from the European Union's Horizon 2020 research and innovation program DynaHealth (grant number: 633595); grants from the Academy of Finland (grant number 1284859 and 12848591); with the support from the Academy of Finland (grant number 12853241) and with the support of the University of Helsinki. The department of Obstetrics and Gynecology UMCG receives an unrestricted educational grant from Ferring Pharmaceutical BV The Netherlands. The authors have no other financial relationships relevant to this article to disclose.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

behavioral problems
lifestyle intervention
neurodevelopment
obesity
Pregnancy

ASJC Scopus subject areas

Developmental and Educational Psychology
Arts and Humanities (miscellaneous)
General Psychology

Access to Document

10.1111/sjop.12575

Cite this

Menting, M. D., van de Beek, C., Rono, K., Hoek, A., Groen, H., Painter, R. C., Girchenko, P., Lahti-Pulkkinen, M., Koivusalo, S. B., Räikkönen, K., Eriksson, J. G., Roseboom, T. J., & Heinonen, K. (2019). Effects of maternal lifestyle interventions on child neurobehavioral development: Follow-up of randomized controlled trials. Scandinavian Journal of Psychology, 60(6), 548-558. https://doi.org/10.1111/sjop.12575

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title = "Effects of maternal lifestyle interventions on child neurobehavioral development: Follow-up of randomized controlled trials",

abstract = "Obesity is a major public health problem. Children of women who were obese before or during pregnancy are at increased risk for neurobehavioral developmental problems. Whether a maternal lifestyle intervention conducted before and during pregnancy in obese women affects child neurobehavioral development is unknown. This study reports on the follow-up of a subsample of two randomized controlled trials, the Finnish RADIEL (n = 216) and Dutch LIFEstyle (n = 305) trial. Women with a pre-pregnancy BMI ≥29 kg/m2 wishing to conceive or who were already pregnant (<20 weeks) were allocated to a lifestyle intervention or to care as usual. Child neurodevelopment was measured with the Ages and Stages Questionnaire and child behavioral problems were measured with the Childhood Behavior Checklist (RADIEL) or the Strengths and Difficulties Questionnaire (LIFEstyle) at age 3-6 years. We used linear and binary logistic regression analyses to assess the effects of the lifestyle interventions on children's neurobehavioral developmental scores. Follow-up data was available from 161(38\%) RADIEL and 96(32\%) LIFEstyle children. Child neurodevelopmental scores did not differ significantly between children in the intervention and the control group (RADIEL:median = 275 vs. 280; LIFEstyle:median = 270 vs 267). Child behavioral problem scores did not differ significantly between children in the intervention and the control group (RADIEL:median = 22 vs. 21; LIFEstyle:median = 8 vs. 8). We did not observe considerable effects of the lifestyle interventions before or during pregnancy in obese women on child neurobehavioral development. With our sample sizes, we were not able to detect subtle differences in neurobehavioral development however.",

keywords = "behavioral problems, lifestyle intervention, neurodevelopment, obesity, Pregnancy",

author = "Menting, \{Malou D.\} and \{van de Beek\}, Cornelieke and Kristiina Rono and Annemieke Hoek and Henk Groen and Painter, \{Rebecca C.\} and Polina Girchenko and Marius Lahti-Pulkkinen and Koivusalo, \{Saila B.\} and Katri R{\"a}ikk{\"o}nen and Eriksson, \{Johan G.\} and Roseboom, \{Tessa J.\} and Kati Heinonen",

note = "Funding Information: This study was conducted with the support of a grant from the Dutch Heart Foundation (grant number 2013T085); a grant from the European Union's Horizon 2020 research and innovation program DynaHealth (grant number: 633595); grants from the Academy of Finland (grant number 1284859 and 12848591); with the support from the Academy of Finland (grant number 12853241) and with the support of the University of Helsinki. The department of Obstetrics and Gynecology UMCG receives an unrestricted educational grant from Ferring Pharmaceutical BV The Netherlands. The authors have no other financial relationships relevant to this article to disclose. Funding Information: This study was conducted with the support of a grant from the Dutch Heart Foundation (grant number 2013T085); a grant from the European Union's Horizon 2020 research and innovation program DynaHealth (grant number: 633595); grants from the Academy of Finland (grant number 1284859 and 12848591); with the support from the Academy of Finland (grant number 12853241) and with the support of the University of Helsinki. The department of Obstetrics and Gynecology UMCG receives an unrestricted educational grant from Ferring Pharmaceutical BV The Netherlands. The authors have no other financial relationships relevant to this article to disclose. Publisher Copyright: {\textcopyright} 2019 The Authors. Scandinavian Journal of Psychology published by Scandinavian Psychological Associations and John Wiley \& Sons Ltd",

year = "2019",

month = dec,

day = "1",

doi = "10.1111/sjop.12575",

language = "English",

volume = "60",

pages = "548--558",

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Menting, MD, van de Beek, C, Rono, K, Hoek, A, Groen, H, Painter, RC, Girchenko, P, Lahti-Pulkkinen, M, Koivusalo, SB, Räikkönen, K, Eriksson, JG, Roseboom, TJ & Heinonen, K 2019, 'Effects of maternal lifestyle interventions on child neurobehavioral development: Follow-up of randomized controlled trials', Scandinavian Journal of Psychology, vol. 60, no. 6, pp. 548-558. https://doi.org/10.1111/sjop.12575

TY - JOUR

T1 - Effects of maternal lifestyle interventions on child neurobehavioral development

T2 - Follow-up of randomized controlled trials

AU - Menting, Malou D.

AU - van de Beek, Cornelieke

AU - Rono, Kristiina

AU - Hoek, Annemieke

AU - Groen, Henk

AU - Painter, Rebecca C.

AU - Girchenko, Polina

AU - Lahti-Pulkkinen, Marius

AU - Koivusalo, Saila B.

AU - Räikkönen, Katri

AU - Eriksson, Johan G.

AU - Roseboom, Tessa J.

AU - Heinonen, Kati

N1 - Funding Information: This study was conducted with the support of a grant from the Dutch Heart Foundation (grant number 2013T085); a grant from the European Union's Horizon 2020 research and innovation program DynaHealth (grant number: 633595); grants from the Academy of Finland (grant number 1284859 and 12848591); with the support from the Academy of Finland (grant number 12853241) and with the support of the University of Helsinki. The department of Obstetrics and Gynecology UMCG receives an unrestricted educational grant from Ferring Pharmaceutical BV The Netherlands. The authors have no other financial relationships relevant to this article to disclose. Funding Information: This study was conducted with the support of a grant from the Dutch Heart Foundation (grant number 2013T085); a grant from the European Union's Horizon 2020 research and innovation program DynaHealth (grant number: 633595); grants from the Academy of Finland (grant number 1284859 and 12848591); with the support from the Academy of Finland (grant number 12853241) and with the support of the University of Helsinki. The department of Obstetrics and Gynecology UMCG receives an unrestricted educational grant from Ferring Pharmaceutical BV The Netherlands. The authors have no other financial relationships relevant to this article to disclose. Publisher Copyright: © 2019 The Authors. Scandinavian Journal of Psychology published by Scandinavian Psychological Associations and John Wiley & Sons Ltd

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Obesity is a major public health problem. Children of women who were obese before or during pregnancy are at increased risk for neurobehavioral developmental problems. Whether a maternal lifestyle intervention conducted before and during pregnancy in obese women affects child neurobehavioral development is unknown. This study reports on the follow-up of a subsample of two randomized controlled trials, the Finnish RADIEL (n = 216) and Dutch LIFEstyle (n = 305) trial. Women with a pre-pregnancy BMI ≥29 kg/m2 wishing to conceive or who were already pregnant (<20 weeks) were allocated to a lifestyle intervention or to care as usual. Child neurodevelopment was measured with the Ages and Stages Questionnaire and child behavioral problems were measured with the Childhood Behavior Checklist (RADIEL) or the Strengths and Difficulties Questionnaire (LIFEstyle) at age 3-6 years. We used linear and binary logistic regression analyses to assess the effects of the lifestyle interventions on children's neurobehavioral developmental scores. Follow-up data was available from 161(38%) RADIEL and 96(32%) LIFEstyle children. Child neurodevelopmental scores did not differ significantly between children in the intervention and the control group (RADIEL:median = 275 vs. 280; LIFEstyle:median = 270 vs 267). Child behavioral problem scores did not differ significantly between children in the intervention and the control group (RADIEL:median = 22 vs. 21; LIFEstyle:median = 8 vs. 8). We did not observe considerable effects of the lifestyle interventions before or during pregnancy in obese women on child neurobehavioral development. With our sample sizes, we were not able to detect subtle differences in neurobehavioral development however.

AB - Obesity is a major public health problem. Children of women who were obese before or during pregnancy are at increased risk for neurobehavioral developmental problems. Whether a maternal lifestyle intervention conducted before and during pregnancy in obese women affects child neurobehavioral development is unknown. This study reports on the follow-up of a subsample of two randomized controlled trials, the Finnish RADIEL (n = 216) and Dutch LIFEstyle (n = 305) trial. Women with a pre-pregnancy BMI ≥29 kg/m2 wishing to conceive or who were already pregnant (<20 weeks) were allocated to a lifestyle intervention or to care as usual. Child neurodevelopment was measured with the Ages and Stages Questionnaire and child behavioral problems were measured with the Childhood Behavior Checklist (RADIEL) or the Strengths and Difficulties Questionnaire (LIFEstyle) at age 3-6 years. We used linear and binary logistic regression analyses to assess the effects of the lifestyle interventions on children's neurobehavioral developmental scores. Follow-up data was available from 161(38%) RADIEL and 96(32%) LIFEstyle children. Child neurodevelopmental scores did not differ significantly between children in the intervention and the control group (RADIEL:median = 275 vs. 280; LIFEstyle:median = 270 vs 267). Child behavioral problem scores did not differ significantly between children in the intervention and the control group (RADIEL:median = 22 vs. 21; LIFEstyle:median = 8 vs. 8). We did not observe considerable effects of the lifestyle interventions before or during pregnancy in obese women on child neurobehavioral development. With our sample sizes, we were not able to detect subtle differences in neurobehavioral development however.

KW - behavioral problems

KW - lifestyle intervention

KW - neurodevelopment

KW - obesity

KW - Pregnancy

U2 - 10.1111/sjop.12575

DO - 10.1111/sjop.12575

M3 - Article

C2 - 31498898

AN - SCOPUS:85073927633

SN - 0036-5564

VL - 60

SP - 548

EP - 558

JO - Scandinavian Journal of Psychology

JF - Scandinavian Journal of Psychology

IS - 6

ER -

Effects of maternal lifestyle interventions on child neurobehavioral development: Follow-up of randomized controlled trials

Abstract

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this