Effects of two double bonds on the hydrocarbon interior of a phospholipid bilayer

Marja Hyvönen; Mika Ala-Korpela; Juha Vaara; Tapio T. Rantala; Jukka Jokisaari

doi:10.1016/0009-2614(95)01113-N

Effects of two double bonds on the hydrocarbon interior of a phospholipid bilayer

Marja Hyvönen^*
, Mika Ala-Korpela
, Juha Vaara
, Tapio T. Rantala
, Jukka Jokisaari

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

7 Citations (Scopus)

Abstract

A phospholipid bilayer was modelled by duplicating a monolayer system of 36 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphatidylcholine (PLPC) molecules ( 16:0 18:2) plus 1368 water molecules and simulated using molecular dynamics. The analyses revealed distinct characteristics in the membrane structure due to polyunsaturation. The orientational behaviour of the fatty acid chains in the PLPC bilayer was found to be seemingly different from that in monounsaturated or in saturated phospholipid bilayers. The specific attributes responsible for the observed behaviour of the saturated and polyunsaturated chains are discussed and their relative importance assessed.

Original language	English
Pages (from-to)	300-306
Number of pages	7
Journal	Chemical Physics Letters
Volume	246
Issue number	3
DOIs	https://doi.org/10.1016/0009-2614(95)01113-N
Publication status	Published - 24 Nov 1995
Externally published	Yes
Publication type	A1 Journal article-refereed

ASJC Scopus subject areas

Physical and Theoretical Chemistry
General Physics and Astronomy

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10.1016/0009-2614(95)01113-N

Cite this

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title = "Effects of two double bonds on the hydrocarbon interior of a phospholipid bilayer",

abstract = "A phospholipid bilayer was modelled by duplicating a monolayer system of 36 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphatidylcholine (PLPC) molecules ( 16:0 18:2) plus 1368 water molecules and simulated using molecular dynamics. The analyses revealed distinct characteristics in the membrane structure due to polyunsaturation. The orientational behaviour of the fatty acid chains in the PLPC bilayer was found to be seemingly different from that in monounsaturated or in saturated phospholipid bilayers. The specific attributes responsible for the observed behaviour of the saturated and polyunsaturated chains are discussed and their relative importance assessed.",

author = "Marja Hyv{\"o}nen and Mika Ala-Korpela and Juha Vaara and Rantala, \{Tapio T.\} and Jukka Jokisaari",

year = "1995",

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doi = "10.1016/0009-2614(95)01113-N",

language = "English",

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T1 - Effects of two double bonds on the hydrocarbon interior of a phospholipid bilayer

AU - Hyvönen, Marja

AU - Ala-Korpela, Mika

AU - Vaara, Juha

AU - Rantala, Tapio T.

AU - Jokisaari, Jukka

PY - 1995/11/24

Y1 - 1995/11/24

N2 - A phospholipid bilayer was modelled by duplicating a monolayer system of 36 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphatidylcholine (PLPC) molecules ( 16:0 18:2) plus 1368 water molecules and simulated using molecular dynamics. The analyses revealed distinct characteristics in the membrane structure due to polyunsaturation. The orientational behaviour of the fatty acid chains in the PLPC bilayer was found to be seemingly different from that in monounsaturated or in saturated phospholipid bilayers. The specific attributes responsible for the observed behaviour of the saturated and polyunsaturated chains are discussed and their relative importance assessed.

AB - A phospholipid bilayer was modelled by duplicating a monolayer system of 36 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphatidylcholine (PLPC) molecules ( 16:0 18:2) plus 1368 water molecules and simulated using molecular dynamics. The analyses revealed distinct characteristics in the membrane structure due to polyunsaturation. The orientational behaviour of the fatty acid chains in the PLPC bilayer was found to be seemingly different from that in monounsaturated or in saturated phospholipid bilayers. The specific attributes responsible for the observed behaviour of the saturated and polyunsaturated chains are discussed and their relative importance assessed.

U2 - 10.1016/0009-2614(95)01113-N

DO - 10.1016/0009-2614(95)01113-N

M3 - Article

AN - SCOPUS:4243491046

SN - 0009-2614

VL - 246

SP - 300

EP - 306

JO - Chemical Physics Letters

JF - Chemical Physics Letters

IS - 3

ER -

Effects of two double bonds on the hydrocarbon interior of a phospholipid bilayer

Abstract

ASJC Scopus subject areas

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