Epileptiform and periodic EEG activities induced by rapid sevoflurane anaesthesia induction

Eila Sonkajärvi, Seppo Rytky, Seppo Alahuhta, Kalervo Suominen, Timo Kumpulainen, Pasi Ohtonen, Elina Karvonen, Ville Jäntti

    Research output: Contribution to journalArticleScientificpeer-review

    3 Citations (Scopus)


    Objectives: The aim of the study was to compare the EEG findings and haemodynamic parameters of adult male patients while undergoing mask induction with sevoflurane anaesthesia with either controlled hyperventilation (CH) or spontaneous breathing (SB). Methods: Twenty male patients, aged 23–52 (mean 42) years were anaesthetized randomly with either spontaneous breathing or mild controlled hyperventilation via mask. EEG was recorded using a full 10–20 electrode set. Results: Anaesthesia induction with high inhaled concentrations of sevoflurane produced several epileptiform and periodic EEG patterns. CH doubled the amount of these EEG patterns compared to SB. Higher heart rate was recorded in the CH group. Conclusions: We describe a high incidence of paroxysmal EEG activity: epileptiform and generalized periodic discharges (GPDs) during rapid sevoflurane in nitrous oxide-oxygen mask induction in hyperventilated male patients. However these activities have no effect to the heart rate or the mean arterial pressure. Significance: The monitoring of GPDs and burst suppression patterns during rapid anaesthesia induction with sevoflurane provides possibility to study the effects of volatile anaesthetics in the healthy brain. In order to analyse the different sources of EEG patterns a wide-band multichannel EEG recording is necessary.

    Original languageEnglish
    Pages (from-to)638-645
    Number of pages8
    JournalClinical Neurophysiology
    Issue number3
    Publication statusPublished - 2018
    Publication typeA1 Journal article-refereed


    • Anaesthesia
    • Burst-suppression
    • EEG
    • Epileptiform
    • GPD
    • Sevoflurane

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    • Publication forum level 1


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