ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents with Celiac Disease

Maria Luisa Mearin; Daniel Agardh; Henedina Antunes; Abdul Al-Toma; Renata Auricchio; Gemma Castillejo; Carlo Catassi; Carolina Ciacci; Valentina Discepolo; Jernej Dolinsek; Ester Donat; Peter Gillett; Steffano Guandalini; Steffen Husby, Md, Dmsc; Sibylle Koletzko, Md; Tunde Koltai; Ilma Rita Korponay-Szabó; Kalle Kurppa; Elena Lionetti; Karl Mårild; Eva Martinez Ojinaga; Caroline Meijer; Chiara Monachesi; Isabel Polanco; Alina Popp; Maria Roca; Alfonso Rodriguez-Herrera; Raanan Shamir; Ketil Stordal; Riccardo Troncone; Francesco Valitutti; Anita Vreugdenhil; Margreet Wessels; Penny Whiting

doi:10.1097/MPG.0000000000003540

ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents with Celiac Disease

Maria Luisa Mearin, Daniel Agardh, Henedina Antunes, Abdul Al-Toma, Renata Auricchio, Gemma Castillejo, Carlo Catassi, Carolina Ciacci, Valentina Discepolo, Jernej Dolinsek, Ester Donat, Peter Gillett, Steffano Guandalini, Steffen Husby, Md, Dmsc, Sibylle Koletzko, Md, Tunde Koltai, Ilma Rita Korponay-Szabó, Kalle Kurppa, Elena Lionetti, Karl MårildEva Martinez Ojinaga, Caroline Meijer, Chiara Monachesi, Isabel Polanco, Alina Popp, Maria Roca, Alfonso Rodriguez-Herrera, Raanan Shamir, Ketil Stordal, Riccardo Troncone, Francesco Valitutti, Anita Vreugdenhil, Margreet Wessels, Penny Whiting

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Abstract

There is a need for consensus on the recommendations for follow-up of children and adolescents with celiac disease. Objectives: To gather the current evidence and to offer recommendations for follow-up and management. Methods: The Special Interest Group on Celiac Diseases of the European Society of Paediatric Gastroenterology Hepatology and Nutrition formulated ten questions considered to be essential for follow-up care. A literature search (January 2010-March 2020) was performed in PubMed or Medline. Relevant publications were identified and potentially eligible studies were assessed. Statements and recommendations were developed and discussed by all coauthors. Recommendations were voted upon: joint agreement was set as at least 85%. Results: Publications (n = 2775) were identified and 164 were included. Using evidence or expert opinion, 37 recommendations were formulated on: The need to perform follow-up, its frequency and what should be assessed, how to assess adherence to the gluten-free diet, when to expect catch-up growth, how to treat anemia, how to approach persistent high serum levels of antibodies against tissue-transglutaminase, the indication to perform biopsies, assessment of quality of life, management of children with unclear diagnosis for which a gluten-challenge is indicated, children with associated type 1 diabetes or IgA deficiency, cases of potential celiac disease, which professionals should perform follow-up, how to improve the communication to patients and their parents/caregivers and transition from pediatric to adult health care. Conclusions: We offer recommendations to improve follow-up of children and adolescents with celiac disease and highlight gaps that should be investigated to further improve management.

Original language	English
Pages (from-to)	369-386
Number of pages	18
Journal	Journal of Pediatric Gastroenterology and Nutrition
Volume	75
Issue number	3
DOIs	https://doi.org/10.1097/MPG.0000000000003540
Publication status	Published - 2022
Publication type	A1 Journal article-refereed

Keywords

celiac disease
children and adolescents
follow-up
position paper European Society of Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN)

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/MPG.0000000000003540

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Mearin, M. L., Agardh, D., Antunes, H., Al-Toma, A., Auricchio, R., Castillejo, G., Catassi, C., Ciacci, C., Discepolo, V., Dolinsek, J., Donat, E., Gillett, P., Guandalini, S., Husby, Md, Dmsc, S., Koletzko, Md, S., Koltai, T., Korponay-Szabó, I. R., Kurppa, K., Lionetti, E., ... Whiting, P. (2022). ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents with Celiac Disease. Journal of Pediatric Gastroenterology and Nutrition, 75(3), 369-386. https://doi.org/10.1097/MPG.0000000000003540

@article{e8fbac014f934146890227a3105cea82,

title = "ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents with Celiac Disease",

abstract = "There is a need for consensus on the recommendations for follow-up of children and adolescents with celiac disease. Objectives: To gather the current evidence and to offer recommendations for follow-up and management. Methods: The Special Interest Group on Celiac Diseases of the European Society of Paediatric Gastroenterology Hepatology and Nutrition formulated ten questions considered to be essential for follow-up care. A literature search (January 2010-March 2020) was performed in PubMed or Medline. Relevant publications were identified and potentially eligible studies were assessed. Statements and recommendations were developed and discussed by all coauthors. Recommendations were voted upon: joint agreement was set as at least 85%. Results: Publications (n = 2775) were identified and 164 were included. Using evidence or expert opinion, 37 recommendations were formulated on: The need to perform follow-up, its frequency and what should be assessed, how to assess adherence to the gluten-free diet, when to expect catch-up growth, how to treat anemia, how to approach persistent high serum levels of antibodies against tissue-transglutaminase, the indication to perform biopsies, assessment of quality of life, management of children with unclear diagnosis for which a gluten-challenge is indicated, children with associated type 1 diabetes or IgA deficiency, cases of potential celiac disease, which professionals should perform follow-up, how to improve the communication to patients and their parents/caregivers and transition from pediatric to adult health care. Conclusions: We offer recommendations to improve follow-up of children and adolescents with celiac disease and highlight gaps that should be investigated to further improve management.",

keywords = "celiac disease, children and adolescents, follow-up, position paper European Society of Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN)",

author = "Mearin, {Maria Luisa} and Daniel Agardh and Henedina Antunes and Abdul Al-Toma and Renata Auricchio and Gemma Castillejo and Carlo Catassi and Carolina Ciacci and Valentina Discepolo and Jernej Dolinsek and Ester Donat and Peter Gillett and Steffano Guandalini and {Husby, Md, Dmsc}, Steffen and {Koletzko, Md}, Sibylle and Tunde Koltai and Korponay-Szab{\'o}, {Ilma Rita} and Kalle Kurppa and Elena Lionetti and Karl M{\aa}rild and {Martinez Ojinaga}, Eva and Caroline Meijer and Chiara Monachesi and Isabel Polanco and Alina Popp and Maria Roca and Alfonso Rodriguez-Herrera and Raanan Shamir and Ketil Stordal and Riccardo Troncone and Francesco Valitutti and Anita Vreugdenhil and Margreet Wessels and Penny Whiting",

note = "Funding Information: The guideline was funded by ESPGHAN and was developed in collaboration with AOECS. Publisher Copyright: {\textcopyright} 2022 Lippincott Williams and Wilkins. All rights reserved.",

year = "2022",

doi = "10.1097/MPG.0000000000003540",

language = "English",

volume = "75",

pages = "369--386",

journal = " Journal of Pediatric Gastroenterology and Nutrition",

issn = "0277-2116",

publisher = "Lippincott, Williams & Wilkins",

number = "3",

}

Mearin, ML, Agardh, D, Antunes, H, Al-Toma, A, Auricchio, R, Castillejo, G, Catassi, C, Ciacci, C, Discepolo, V, Dolinsek, J, Donat, E, Gillett, P, Guandalini, S, Husby, Md, Dmsc, S, Koletzko, Md, S, Koltai, T, Korponay-Szabó, IR, Kurppa, K, Lionetti, E, Mårild, K, Martinez Ojinaga, E, Meijer, C, Monachesi, C, Polanco, I, Popp, A, Roca, M, Rodriguez-Herrera, A, Shamir, R, Stordal, K, Troncone, R, Valitutti, F, Vreugdenhil, A, Wessels, M & Whiting, P 2022, 'ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents with Celiac Disease', Journal of Pediatric Gastroenterology and Nutrition, vol. 75, no. 3, pp. 369-386. https://doi.org/10.1097/MPG.0000000000003540

TY - JOUR

T1 - ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents with Celiac Disease

AU - Mearin, Maria Luisa

AU - Agardh, Daniel

AU - Antunes, Henedina

AU - Al-Toma, Abdul

AU - Auricchio, Renata

AU - Castillejo, Gemma

AU - Catassi, Carlo

AU - Ciacci, Carolina

AU - Discepolo, Valentina

AU - Dolinsek, Jernej

AU - Donat, Ester

AU - Gillett, Peter

AU - Guandalini, Steffano

AU - Husby, Md, Dmsc, Steffen

AU - Koletzko, Md, Sibylle

AU - Koltai, Tunde

AU - Korponay-Szabó, Ilma Rita

AU - Kurppa, Kalle

AU - Lionetti, Elena

AU - Mårild, Karl

AU - Martinez Ojinaga, Eva

AU - Meijer, Caroline

AU - Monachesi, Chiara

AU - Polanco, Isabel

AU - Popp, Alina

AU - Roca, Maria

AU - Rodriguez-Herrera, Alfonso

AU - Shamir, Raanan

AU - Stordal, Ketil

AU - Troncone, Riccardo

AU - Valitutti, Francesco

AU - Vreugdenhil, Anita

AU - Wessels, Margreet

AU - Whiting, Penny

PY - 2022

Y1 - 2022

N2 - There is a need for consensus on the recommendations for follow-up of children and adolescents with celiac disease. Objectives: To gather the current evidence and to offer recommendations for follow-up and management. Methods: The Special Interest Group on Celiac Diseases of the European Society of Paediatric Gastroenterology Hepatology and Nutrition formulated ten questions considered to be essential for follow-up care. A literature search (January 2010-March 2020) was performed in PubMed or Medline. Relevant publications were identified and potentially eligible studies were assessed. Statements and recommendations were developed and discussed by all coauthors. Recommendations were voted upon: joint agreement was set as at least 85%. Results: Publications (n = 2775) were identified and 164 were included. Using evidence or expert opinion, 37 recommendations were formulated on: The need to perform follow-up, its frequency and what should be assessed, how to assess adherence to the gluten-free diet, when to expect catch-up growth, how to treat anemia, how to approach persistent high serum levels of antibodies against tissue-transglutaminase, the indication to perform biopsies, assessment of quality of life, management of children with unclear diagnosis for which a gluten-challenge is indicated, children with associated type 1 diabetes or IgA deficiency, cases of potential celiac disease, which professionals should perform follow-up, how to improve the communication to patients and their parents/caregivers and transition from pediatric to adult health care. Conclusions: We offer recommendations to improve follow-up of children and adolescents with celiac disease and highlight gaps that should be investigated to further improve management.

AB - There is a need for consensus on the recommendations for follow-up of children and adolescents with celiac disease. Objectives: To gather the current evidence and to offer recommendations for follow-up and management. Methods: The Special Interest Group on Celiac Diseases of the European Society of Paediatric Gastroenterology Hepatology and Nutrition formulated ten questions considered to be essential for follow-up care. A literature search (January 2010-March 2020) was performed in PubMed or Medline. Relevant publications were identified and potentially eligible studies were assessed. Statements and recommendations were developed and discussed by all coauthors. Recommendations were voted upon: joint agreement was set as at least 85%. Results: Publications (n = 2775) were identified and 164 were included. Using evidence or expert opinion, 37 recommendations were formulated on: The need to perform follow-up, its frequency and what should be assessed, how to assess adherence to the gluten-free diet, when to expect catch-up growth, how to treat anemia, how to approach persistent high serum levels of antibodies against tissue-transglutaminase, the indication to perform biopsies, assessment of quality of life, management of children with unclear diagnosis for which a gluten-challenge is indicated, children with associated type 1 diabetes or IgA deficiency, cases of potential celiac disease, which professionals should perform follow-up, how to improve the communication to patients and their parents/caregivers and transition from pediatric to adult health care. Conclusions: We offer recommendations to improve follow-up of children and adolescents with celiac disease and highlight gaps that should be investigated to further improve management.

KW - celiac disease

KW - children and adolescents

KW - follow-up

KW - position paper European Society of Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN)

U2 - 10.1097/MPG.0000000000003540

DO - 10.1097/MPG.0000000000003540

M3 - Article

C2 - 35758521

AN - SCOPUS:85136851907

SN - 0277-2116

VL - 75

SP - 369

EP - 386

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

IS - 3

ER -

ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents with Celiac Disease

Abstract

Keywords

Publication forum classification

ASJC Scopus subject areas

UN SDGs

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