TY - JOUR
T1 - ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents with Celiac Disease
AU - Mearin, Maria Luisa
AU - Agardh, Daniel
AU - Antunes, Henedina
AU - Al-Toma, Abdul
AU - Auricchio, Renata
AU - Castillejo, Gemma
AU - Catassi, Carlo
AU - Ciacci, Carolina
AU - Discepolo, Valentina
AU - Dolinsek, Jernej
AU - Donat, Ester
AU - Gillett, Peter
AU - Guandalini, Steffano
AU - Husby, Md, Dmsc, Steffen
AU - Koletzko, Md, Sibylle
AU - Koltai, Tunde
AU - Korponay-Szabó, Ilma Rita
AU - Kurppa, Kalle
AU - Lionetti, Elena
AU - Mårild, Karl
AU - Martinez Ojinaga, Eva
AU - Meijer, Caroline
AU - Monachesi, Chiara
AU - Polanco, Isabel
AU - Popp, Alina
AU - Roca, Maria
AU - Rodriguez-Herrera, Alfonso
AU - Shamir, Raanan
AU - Stordal, Ketil
AU - Troncone, Riccardo
AU - Valitutti, Francesco
AU - Vreugdenhil, Anita
AU - Wessels, Margreet
AU - Whiting, Penny
N1 - Funding Information:
The guideline was funded by ESPGHAN and was developed in collaboration with AOECS.
Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022
Y1 - 2022
N2 - There is a need for consensus on the recommendations for follow-up of children and adolescents with celiac disease. Objectives: To gather the current evidence and to offer recommendations for follow-up and management. Methods: The Special Interest Group on Celiac Diseases of the European Society of Paediatric Gastroenterology Hepatology and Nutrition formulated ten questions considered to be essential for follow-up care. A literature search (January 2010-March 2020) was performed in PubMed or Medline. Relevant publications were identified and potentially eligible studies were assessed. Statements and recommendations were developed and discussed by all coauthors. Recommendations were voted upon: joint agreement was set as at least 85%. Results: Publications (n = 2775) were identified and 164 were included. Using evidence or expert opinion, 37 recommendations were formulated on: The need to perform follow-up, its frequency and what should be assessed, how to assess adherence to the gluten-free diet, when to expect catch-up growth, how to treat anemia, how to approach persistent high serum levels of antibodies against tissue-transglutaminase, the indication to perform biopsies, assessment of quality of life, management of children with unclear diagnosis for which a gluten-challenge is indicated, children with associated type 1 diabetes or IgA deficiency, cases of potential celiac disease, which professionals should perform follow-up, how to improve the communication to patients and their parents/caregivers and transition from pediatric to adult health care. Conclusions: We offer recommendations to improve follow-up of children and adolescents with celiac disease and highlight gaps that should be investigated to further improve management.
AB - There is a need for consensus on the recommendations for follow-up of children and adolescents with celiac disease. Objectives: To gather the current evidence and to offer recommendations for follow-up and management. Methods: The Special Interest Group on Celiac Diseases of the European Society of Paediatric Gastroenterology Hepatology and Nutrition formulated ten questions considered to be essential for follow-up care. A literature search (January 2010-March 2020) was performed in PubMed or Medline. Relevant publications were identified and potentially eligible studies were assessed. Statements and recommendations were developed and discussed by all coauthors. Recommendations were voted upon: joint agreement was set as at least 85%. Results: Publications (n = 2775) were identified and 164 were included. Using evidence or expert opinion, 37 recommendations were formulated on: The need to perform follow-up, its frequency and what should be assessed, how to assess adherence to the gluten-free diet, when to expect catch-up growth, how to treat anemia, how to approach persistent high serum levels of antibodies against tissue-transglutaminase, the indication to perform biopsies, assessment of quality of life, management of children with unclear diagnosis for which a gluten-challenge is indicated, children with associated type 1 diabetes or IgA deficiency, cases of potential celiac disease, which professionals should perform follow-up, how to improve the communication to patients and their parents/caregivers and transition from pediatric to adult health care. Conclusions: We offer recommendations to improve follow-up of children and adolescents with celiac disease and highlight gaps that should be investigated to further improve management.
KW - celiac disease
KW - children and adolescents
KW - follow-up
KW - position paper European Society of Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN)
U2 - 10.1097/MPG.0000000000003540
DO - 10.1097/MPG.0000000000003540
M3 - Article
C2 - 35758521
AN - SCOPUS:85136851907
SN - 0277-2116
VL - 75
SP - 369
EP - 386
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
IS - 3
ER -