Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-y l)-3-oxopropanenitrile (CP-690,550).

JK Jiang; W Leister; S Costanzi; JJ O'Shea; CJ Thomas; K Ghoreschi; F Deflorian; Z Chen; M Perreira; M Pesu; J Smith; DT Nguyen; EH Liu

doi:10.1021/jm801142b

Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-y l)-3-oxopropanenitrile (CP-690,550).

JK Jiang
, W Leister
, S Costanzi
, JJ O'Shea
, CJ Thomas
, K Ghoreschi
, F Deflorian
, Z Chen
, M Perreira
, M Pesu
, J Smith
, DT Nguyen
, EH Liu

Research output: Contribution to journal › Article › Scientific › peer-review

116 Citations (Scopus)

Original language	English
Pages (from-to)	8012-8
Journal	Journal of Medicinal Chemistry
Volume	51
Issue number	24
DOIs	https://doi.org/10.1021/jm801142b
Publication status	Published - 2008
Externally published	Yes
Publication type	A1 Journal article-refereed

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10.1021/jm801142b

Cite this

Jiang, JK., Leister, W., Costanzi, S., O'Shea, JJ., Thomas, CJ., Ghoreschi, K., Deflorian, F., Chen, Z., Perreira, M., Pesu, M., Smith, J., Nguyen, DT., & Liu, EH. (2008). Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-y l)-3-oxopropanenitrile (CP-690,550). Journal of Medicinal Chemistry, 51(24), 8012-8. https://doi.org/10.1021/jm801142b

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title = "Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-y l)-3-oxopropanenitrile (CP-690,550).",

author = "JK Jiang and W Leister and S Costanzi and JJ O'Shea and CJ Thomas and K Ghoreschi and F Deflorian and Z Chen and M Perreira and M Pesu and J Smith and DT Nguyen and EH Liu",

year = "2008",

doi = "10.1021/jm801142b",

language = "English",

volume = "51",

pages = "8012--8",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "24",

}

Jiang, JK, Leister, W, Costanzi, S, O'Shea, JJ, Thomas, CJ, Ghoreschi, K, Deflorian, F, Chen, Z, Perreira, M, Pesu, M, Smith, J, Nguyen, DT & Liu, EH 2008, 'Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-y l)-3-oxopropanenitrile (CP-690,550).', Journal of Medicinal Chemistry, vol. 51, no. 24, pp. 8012-8. https://doi.org/10.1021/jm801142b

Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-y l)-3-oxopropanenitrile (CP-690,550). / Jiang, JK; Leister, W; Costanzi, S et al.
In: Journal of Medicinal Chemistry, Vol. 51, No. 24, 2008, p. 8012-8.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-y l)-3-oxopropanenitrile (CP-690,550).

AU - Jiang, JK

AU - Leister, W

AU - Costanzi, S

AU - O'Shea, JJ

AU - Thomas, CJ

AU - Ghoreschi, K

AU - Deflorian, F

AU - Chen, Z

AU - Perreira, M

AU - Pesu, M

AU - Smith, J

AU - Nguyen, DT

AU - Liu, EH

PY - 2008

Y1 - 2008

U2 - 10.1021/jm801142b

DO - 10.1021/jm801142b

M3 - Article

SN - 0022-2623

VL - 51

SP - 8012

EP - 8018

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 24

ER -