Existence of snoRNA, microRNA, piRNA characteristics in a novel non-coding RNA: x-ncRNA and its biological implication in Homo sapiens

Meenakshisundaram Kandhavelu, Carmen Lammi, Michela Buccioni, Diego Dal Ben, Rosaria Volpini, Gabriella Marucci

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Comparative genomic analysis constitutes a powerful approach for the systematic understanding of genome. The comparative and evolutionary analysis of known microRNAs in Homo sapiens elucidates the discovery of the existence of the novel non-coding RNA, which is transcribed from the unique gene precursor and produces three different non coding RNAs such as piRNA, snoRNA and microRNA. This new characteristics RNA is named as x-non coding RNA (x-ncRNA). This characteristic pattern shows evolutionary signatures dictated by its precise selective significance and synteny. The evidence of x-ncRNA processing and functionality from hairpin arms were proven by systematic analysis. x-ncRNA analysis proven the bio genesis of human piRNA is originated from the dsDNA, which is also involved in the synthesis of piRNA and/or microRNA, through dicer. These data also shows the presence of human sno-microRNA. Our data demonstrates that the existence of x-ncRNA, genomic origin, conceivable bio genesis pathway, evolutionary relationship and its functions.
Original languageEnglish
Pages (from-to)31-40
JournalJournal of Bioinformatics and Sequence Analysis
Volume1(2)
Publication statusPublished - 2009
Externally publishedYes
Publication typeA1 Journal article-refereed

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