Experimental use of photodynamic therapy in high grade gliomas: a review focused on 5-aminolevulinic acid

Marie Charlotte Tetard; Maximilien Vermandel; Serge Mordon; Jean Paul Lejeune; Nicolas Reyns

doi:10.1016/j.pdpdt.2014.04.004

Experimental use of photodynamic therapy in high grade gliomas: a review focused on 5-aminolevulinic acid

Marie Charlotte Tetard, Maximilien Vermandel, Serge Mordon, Jean Paul Lejeune, Nicolas Reyns

Research output: Contribution to journal › Review Article › peer-review

49 Citations (Scopus)

Abstract

Photodynamic therapy (PDT) consists of a laser light exposure of tumor cells photosensitized by general or local administration of a pharmacological agent. Nowadays, PDT is a clinically established modality for treatment of many cancers. 5-Aminolevulinic acid (ALA) induced protoporphyrin IX (PpIX) has proven its rational in fluoro-guided resection of malignant gliomas due to a selective tumor uptake and minimal skin sensitization. Moreover, the relatively specific accumulation of photosensitizing PPIX within the tumor cells has gained interest in the PDT of malignant gliomas. Several experimental and clinical studies have then established ALA-PDT as a valuable adjuvant therapy in the management of malignant gliomas. However, the procedure still requires optimizations in the fields of tissue oxygenation status, photosensitizer concentration or scheme of laser light illumination. In this extensive review, we focused on the methods and results of ALA-PDT for treating malignant gliomas in experimental conditions. The biological mechanisms, the effects on tumor and normal brain tissue, and finally the critical issues to optimize the efficacy of ALA-PDT were discussed.

Original language	English
Pages (from-to)	319-330
Number of pages	12
Journal	PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/j.pdpdt.2014.04.004
Publication status	Published - 1 Sept 2014
Publication type	A2 Review article in a scientific journal

Keywords

5-Aminolevulinic acid (ALA)
Brain tumor
High-grade glioma
Photodynamic therapy
Preclinical model

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pdpdt.2014.04.004

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title = "Experimental use of photodynamic therapy in high grade gliomas: a review focused on 5-aminolevulinic acid",

abstract = "Photodynamic therapy (PDT) consists of a laser light exposure of tumor cells photosensitized by general or local administration of a pharmacological agent. Nowadays, PDT is a clinically established modality for treatment of many cancers. 5-Aminolevulinic acid (ALA) induced protoporphyrin IX (PpIX) has proven its rational in fluoro-guided resection of malignant gliomas due to a selective tumor uptake and minimal skin sensitization. Moreover, the relatively specific accumulation of photosensitizing PPIX within the tumor cells has gained interest in the PDT of malignant gliomas. Several experimental and clinical studies have then established ALA-PDT as a valuable adjuvant therapy in the management of malignant gliomas. However, the procedure still requires optimizations in the fields of tissue oxygenation status, photosensitizer concentration or scheme of laser light illumination. In this extensive review, we focused on the methods and results of ALA-PDT for treating malignant gliomas in experimental conditions. The biological mechanisms, the effects on tumor and normal brain tissue, and finally the critical issues to optimize the efficacy of ALA-PDT were discussed. ",

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AU - Lejeune, Jean Paul

AU - Reyns, Nicolas

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Experimental use of photodynamic therapy in high grade gliomas: a review focused on 5-aminolevulinic acid

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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