Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi

Zhifei Liu; Yue-Mei Fan; Per Ashorn; Yin Bun Cheung; Lotta Hallamaa; Heikki Hyöty; Kenneth Maleta; Kirsi-Maarit Lehto; Sami Oikarinen; Seppo Parkkila; Ulla Ashorn

doi:10.1111/jpc.15231

Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi

Zhifei Liu, Yue-Mei Fan, Per Ashorn, Yin Bun Cheung, Lotta Hallamaa, Heikki Hyöty, Kenneth Maleta, Kirsi-Maarit Lehto, Sami Oikarinen, Seppo Parkkila, Ulla Ashorn

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Abstract

AIM: This study was designed to determine whether faecal regenerating 1B protein (REG1B) concentration is associated with physical growth among 6-30-month-old children in rural Malawi.

METHODS: This was a secondary analysis from a randomised controlled trial in rural Malawi in which we followed-up 790 live-born infants from birth to 30 months of age. We collected anthropometric data at the age of 6, 12, 18, 24 and 30 months. We measured faecal REG1B concentration by enzyme-linked immunosorbent assay (ELISA) technique using stool samples collected at 6, 18 and 30 months of age. We assessed the association between faecal REG1B concentration and children's physical growth using linear regression and longitudinal data analysis.

RESULTS: Of 790 live-born infants enrolled, 694 (87%) with at least one faecal REG1B concentration measurement were included in the analysis. Faecal REG1B concentration was not associated with the children's concurrent length-for-age z-score (LAZ), weight-for-age z-score (WAZ), weight-for-length z-score (WLZ) and mid-upper arm circumference-for-age z-score (MUACZ) at any time point (P > 0.05), nor with a change in their anthropometric indices in the subsequent 6-month period (P > 0.05).

CONCLUSIONS: Faecal REG1B concentration is not associated with LAZ, WAZ, WLZ and MUACZ among 6-30-month-old infants and children in rural Malawi.

Original language	English
Pages (from-to)	388-394
Journal	JOURNAL OF PAEDIATRICS AND CHILD HEALTH
Volume	57
Issue number	3
Early online date	28 Oct 2020
DOIs	https://doi.org/10.1111/jpc.15231
Publication status	Published - Mar 2021
Publication type	A1 Journal article-refereed

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http://urn.fi/URN:NBN:fi:tuni-202012148782Licence: CC BY

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@article{3cce06b757fc4c3887bafd2bb84672e3,

title = "Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi",

abstract = "AIM: This study was designed to determine whether faecal regenerating 1B protein (REG1B) concentration is associated with physical growth among 6-30-month-old children in rural Malawi.METHODS: This was a secondary analysis from a randomised controlled trial in rural Malawi in which we followed-up 790 live-born infants from birth to 30 months of age. We collected anthropometric data at the age of 6, 12, 18, 24 and 30 months. We measured faecal REG1B concentration by enzyme-linked immunosorbent assay (ELISA) technique using stool samples collected at 6, 18 and 30 months of age. We assessed the association between faecal REG1B concentration and children's physical growth using linear regression and longitudinal data analysis.RESULTS: Of 790 live-born infants enrolled, 694 (87%) with at least one faecal REG1B concentration measurement were included in the analysis. Faecal REG1B concentration was not associated with the children's concurrent length-for-age z-score (LAZ), weight-for-age z-score (WAZ), weight-for-length z-score (WLZ) and mid-upper arm circumference-for-age z-score (MUACZ) at any time point (P > 0.05), nor with a change in their anthropometric indices in the subsequent 6-month period (P > 0.05).CONCLUSIONS: Faecal REG1B concentration is not associated with LAZ, WAZ, WLZ and MUACZ among 6-30-month-old infants and children in rural Malawi.",

author = "Zhifei Liu and Yue-Mei Fan and Per Ashorn and Cheung, {Yin Bun} and Lotta Hallamaa and Heikki Hy{\"o}ty and Kenneth Maleta and Kirsi-Maarit Lehto and Sami Oikarinen and Seppo Parkkila and Ulla Ashorn",

note = "{\textcopyright} 2020 The Authors. Journal of Paediatrics and Child Health published by John Wiley & Sons Australia, Ltd on behalf of Paediatrics and Child Health Division (The Royal Australasian College of Physicians).",

year = "2021",

month = mar,

doi = "10.1111/jpc.15231",

language = "English",

volume = "57",

pages = "388--394",

journal = "JOURNAL OF PAEDIATRICS AND CHILD HEALTH",

issn = "1034-4810",

publisher = "John Wiley and Sons Inc.",

number = "3",

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TY - JOUR

T1 - Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi

AU - Liu, Zhifei

AU - Fan, Yue-Mei

AU - Ashorn, Per

AU - Cheung, Yin Bun

AU - Hallamaa, Lotta

AU - Hyöty, Heikki

AU - Maleta, Kenneth

AU - Lehto, Kirsi-Maarit

AU - Oikarinen, Sami

AU - Parkkila, Seppo

AU - Ashorn, Ulla

N1 - © 2020 The Authors. Journal of Paediatrics and Child Health published by John Wiley & Sons Australia, Ltd on behalf of Paediatrics and Child Health Division (The Royal Australasian College of Physicians).

PY - 2021/3

Y1 - 2021/3

N2 - AIM: This study was designed to determine whether faecal regenerating 1B protein (REG1B) concentration is associated with physical growth among 6-30-month-old children in rural Malawi.METHODS: This was a secondary analysis from a randomised controlled trial in rural Malawi in which we followed-up 790 live-born infants from birth to 30 months of age. We collected anthropometric data at the age of 6, 12, 18, 24 and 30 months. We measured faecal REG1B concentration by enzyme-linked immunosorbent assay (ELISA) technique using stool samples collected at 6, 18 and 30 months of age. We assessed the association between faecal REG1B concentration and children's physical growth using linear regression and longitudinal data analysis.RESULTS: Of 790 live-born infants enrolled, 694 (87%) with at least one faecal REG1B concentration measurement were included in the analysis. Faecal REG1B concentration was not associated with the children's concurrent length-for-age z-score (LAZ), weight-for-age z-score (WAZ), weight-for-length z-score (WLZ) and mid-upper arm circumference-for-age z-score (MUACZ) at any time point (P > 0.05), nor with a change in their anthropometric indices in the subsequent 6-month period (P > 0.05).CONCLUSIONS: Faecal REG1B concentration is not associated with LAZ, WAZ, WLZ and MUACZ among 6-30-month-old infants and children in rural Malawi.

AB - AIM: This study was designed to determine whether faecal regenerating 1B protein (REG1B) concentration is associated with physical growth among 6-30-month-old children in rural Malawi.METHODS: This was a secondary analysis from a randomised controlled trial in rural Malawi in which we followed-up 790 live-born infants from birth to 30 months of age. We collected anthropometric data at the age of 6, 12, 18, 24 and 30 months. We measured faecal REG1B concentration by enzyme-linked immunosorbent assay (ELISA) technique using stool samples collected at 6, 18 and 30 months of age. We assessed the association between faecal REG1B concentration and children's physical growth using linear regression and longitudinal data analysis.RESULTS: Of 790 live-born infants enrolled, 694 (87%) with at least one faecal REG1B concentration measurement were included in the analysis. Faecal REG1B concentration was not associated with the children's concurrent length-for-age z-score (LAZ), weight-for-age z-score (WAZ), weight-for-length z-score (WLZ) and mid-upper arm circumference-for-age z-score (MUACZ) at any time point (P > 0.05), nor with a change in their anthropometric indices in the subsequent 6-month period (P > 0.05).CONCLUSIONS: Faecal REG1B concentration is not associated with LAZ, WAZ, WLZ and MUACZ among 6-30-month-old infants and children in rural Malawi.

U2 - 10.1111/jpc.15231

DO - 10.1111/jpc.15231

M3 - Article

C2 - 33112481

SN - 1034-4810

VL - 57

SP - 388

EP - 394

JO - JOURNAL OF PAEDIATRICS AND CHILD HEALTH

JF - JOURNAL OF PAEDIATRICS AND CHILD HEALTH

IS - 3

ER -

Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi

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