Familial aggregation of early-onset cancers in early-onset breast cancer families

Jasmiina N.J. Rantala, Sanna M.M. Heikkinen, Elli M. Hirvonen, Tomas Tanskanen, Nea K. Malila, Janne M. Pitkäniemi

Research output: Contribution to journalArticleScientificpeer-review

2 Downloads (Pure)


The risk of early-onset (EO) breast cancer is known to be increased in relatives of EO breast cancer patients, but less is known about the familial risk of other EO cancers. We assessed familial risks of EO cancers (aged ≤40 years) other than breast cancer in 54 753 relatives of 5562 women with EO breast cancer (probands) by using a population-based cohort from Finland. Standardized incidence ratios (SIRs) and 95% confidence intervals (CI) were estimated by using gender-, age- and period-specific cancer incidences of the general population as reference. The risk of any cancer excluding breast cancer in first-degree relatives was comparable to population cancer risk (SIR 0.99, 95% CI: 0.84-1.16). Siblings' children of women with EO breast cancer were at an elevated risk of EO testicular and ovarian cancer (SIR = 1.74, 95% CI: 1.07-2.69 and 2.69, 95% CI: 1.08-5.53, respectively). The risk of EO pancreatic cancer was elevated in siblings of the probands (7.61, 95% CI: 1.57-22.23) and an increased risk of any other cancer than breast cancer was observed in children of the probands (1.27, 95% CI: 1.03-1.55). In conclusion, relatives of women with EO breast cancer are at higher familial risk of certain discordant EO cancers, with the risk extending beyond first-degree relatives.

Original languageEnglish
Pages (from-to)331-340
Number of pages10
JournalInternational journal of cancer
Issue number2
Publication statusPublished - 2023
Publication typeA1 Journal article-refereed


  • early-onset breast cancer
  • familial aggregation
  • ovarian cancer
  • pancreatic cancer
  • testicular cancer

Publication forum classification

  • Publication forum level 2

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Familial aggregation of early-onset cancers in early-onset breast cancer families'. Together they form a unique fingerprint.

Cite this