Familial aggregation of early-onset haematological malignancies

Rosa Rönkkö, Elli Hirvonen, Nea Malila, Outi Kilpivaara, Ulla Wartiovaara-Kautto, Janne Pitkäniemi

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Abstract

Population-based studies on familial aggregation of haematological malignancies (HM) have rarely focused specifically on early-onset HMs. We estimated standardized incidence ratios (SIR) and cumulative risks of relatives with Hodgkin lymphoma (HL), non-Hodgkin lymphomas (NHL), acute lymphoblastic leukaemia/lymphoma (ALL/LBL) and acute myeloid leukaemia (AML) when index persons and relatives were diagnosed with early-onset HM. A total of 8791 patients aged ≤40 years and diagnosed with primary HM in Finland from 1970 to 2012 were identified from the Finnish Cancer Registry and their 75 774 family members were retrieved from the population registry. SIRs for concordant HMs were elevated among first-degree relatives in all of the most common HMs of children and adolescents and young adults (AYA). The risk was highest among siblings with HL (SIR 9·09, 95% confidence interval 5·55–14·04) and AML (8·29, 1·00–29·96). HL also had the highest cumulative risk for siblings at ≤40 years of age (0·92% vs. 0·11% in the population). In conclusion, significantly elevated SIRs indicate a role of shared aetiological factors in some families, which should be noted in the clinical setting when caring for patients with early-onset HMs.

Original languageEnglish
Number of pages8
JournalBritish Journal of Haematology
Volume193
Issue number6
DOIs
Publication statusPublished - 2021
Publication typeA1 Journal article-refereed

Keywords

  • aetiology
  • epidemiology
  • genetics
  • haematological malignancies
  • leukaemia
  • lymphomas

Publication forum classification

  • Publication forum level 2

ASJC Scopus subject areas

  • Hematology

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