Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes

Antti Mathias Taka; Anna But; Johanna Lempainen; Tommi Vatanen; Taina Härkönen; Jorma Ilonen; Mikael Knip

doi:10.1016/j.diabres.2023.110256

Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes

Antti Mathias Taka
, Anna But
, Johanna Lempainen
, Tommi Vatanen
, Taina Härkönen
, Jorma Ilonen
, Mikael Knip^*

^*Corresponding author for this work

LAST, Paediatrics

Research output: Contribution to journal › Article › Scientific › peer-review

2 Citations (Scopus)

14 Downloads (Pure)

Abstract

The association between HLA genotypes and type 1 diabetes is well known. We set out to examine incidence rates and ratios of type 1 diabetes depending on the risk afflicted by HLA genotype. Children with the high-risk genotype have a 45-fold disease risk compared to peers with neutral or protective genotypes.

Original language	English
Article number	110256
Number of pages	3
Journal	Diabetes Research and Clinical Practice
Volume	197
DOIs	https://doi.org/10.1016/j.diabres.2023.110256
Publication status	Published - Mar 2023
Publication type	A1 Journal article-refereed

Funding

This work was supported by Helsinki University Hospital Research Funds, Finska Läkaresällskapet, Lastentautien tutkimussäätiö and Medicinska understödsföreningen Liv och Hälsa.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Genetic risk
HLA genotype
Incidence
Type 1 diabetes

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

Access to Document

10.1016/j.diabres.2023.110256Licence: CC BY

1-s2.0-S0168822723000219-mainFinal published version, 317 KBLicence: CC BY

https://urn.fi/URN:NBN:fi:tuni-202307067132Licence: CC BY

Cite this

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title = "Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes",

abstract = "The association between HLA genotypes and type 1 diabetes is well known. We set out to examine incidence rates and ratios of type 1 diabetes depending on the risk afflicted by HLA genotype. Children with the high-risk genotype have a 45-fold disease risk compared to peers with neutral or protective genotypes.",

keywords = "Genetic risk, HLA genotype, Incidence, Type 1 diabetes",

author = "Taka, \{Antti Mathias\} and Anna But and Johanna Lempainen and Tommi Vatanen and Taina H{\"a}rk{\"o}nen and Jorma Ilonen and Mikael Knip",

note = "Funding Information: This work was supported by Helsinki University Hospital Research Funds, Finska L{\"a}kares{\"a}llskapet, Lastentautien tutkimuss{\"a}{\"a}ti{\"o} and Medicinska underst{\"o}dsf{\"o}reningen Liv och H{\"a}lsa. Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = mar,

doi = "10.1016/j.diabres.2023.110256",

language = "English",

volume = "197",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

publisher = "Elsevier",

}

Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes. / Taka, Antti Mathias; But, Anna; Lempainen, Johanna et al.
In: Diabetes Research and Clinical Practice, Vol. 197, 110256, 03.2023.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes

AU - Taka, Antti Mathias

AU - But, Anna

AU - Lempainen, Johanna

AU - Vatanen, Tommi

AU - Härkönen, Taina

AU - Ilonen, Jorma

AU - Knip, Mikael

N1 - Funding Information: This work was supported by Helsinki University Hospital Research Funds, Finska Läkaresällskapet, Lastentautien tutkimussäätiö and Medicinska understödsföreningen Liv och Hälsa. Publisher Copyright: © 2023 The Authors

PY - 2023/3

Y1 - 2023/3

N2 - The association between HLA genotypes and type 1 diabetes is well known. We set out to examine incidence rates and ratios of type 1 diabetes depending on the risk afflicted by HLA genotype. Children with the high-risk genotype have a 45-fold disease risk compared to peers with neutral or protective genotypes.

AB - The association between HLA genotypes and type 1 diabetes is well known. We set out to examine incidence rates and ratios of type 1 diabetes depending on the risk afflicted by HLA genotype. Children with the high-risk genotype have a 45-fold disease risk compared to peers with neutral or protective genotypes.

KW - Genetic risk

KW - HLA genotype

KW - Incidence

KW - Type 1 diabetes

U2 - 10.1016/j.diabres.2023.110256

DO - 10.1016/j.diabres.2023.110256

M3 - Article

C2 - 36640866

AN - SCOPUS:85147807725

SN - 0168-8227

VL - 197

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

M1 - 110256

ER -

Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes

Abstract

Funding

UN SDGs

Keywords

Publication forum classification

ASJC Scopus subject areas

Access to Document

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