From in silico astrocyte cell models to neuron-astrocyte network models: A review

Franziska Oschmann, Hugues Berry, Klaus Obermayer, Kerstin Lenk

    Research output: Contribution to journalReview Articlepeer-review

    21 Citations (Scopus)

    Abstract

    The idea that astrocytes may be active partners in synaptic information processing has recently emerged from abundant experimental reports. Because of their spatial proximity to neurons and their bidirectional communication with them, astrocytes are now considered as an important third element of the synapse. Astrocytes integrate and process synaptic information and by doing so generate cytosolic calcium signals that are believed to reflect neuronal transmitter release. Moreover, they regulate neuronal information transmission by releasing gliotransmitters into the synaptic cleft affecting both pre- and postsynaptic receptors. Concurrent with the first experimental reports of the astrocytic impact on neural network dynamics, computational models describing astrocytic functions have been developed. In this review, we give an overview over the published computational models of astrocytic functions, from single-cell dynamics to the tripartite synapse level and network models of astrocytes and neurons.

    Original languageEnglish
    Pages (from-to)76-84
    JournalBRAIN RESEARCH BULLETIN
    Volume136
    Early online date8 Feb 2017
    DOIs
    Publication statusPublished - 2018
    Publication typeA2 Review article in a scientific journal

    Keywords

    • Astrocyte
    • In silico
    • Network
    • Neuron
    • Simulation
    • Tripartite synapse

    Publication forum classification

    • Publication forum level 1

    ASJC Scopus subject areas

    • Neuroscience(all)

    Fingerprint Dive into the research topics of 'From in silico astrocyte cell models to neuron-astrocyte network models: A review'. Together they form a unique fingerprint.

    Cite this