General principles for the validation of proarrhythmia risk prediction models: an extension of the CiPA In Silico strategy

Zhihua Li; Gary Mirams; Takashi Yoshinaga; Bradley Ridder; Xiaomei Han; Janell E. Chen; Norman L. Stockbridge; Todd A. Wisialowski; Bruce Damiano; Stefano Severi; Pierre Morissette; Peter R. Kowey; Mark Holbrook; Godfrey Smith; Randall L. Rasmusson; Michael Liu; Zhen Song; Zhilin Qu; Derek J. Leishman; Jill Steidl‐Nichols; Blanca Rodriguez; Alfonso Bueno-Orovio; Xin Zhou; Elisa Passini; Andrew G. Edwards; Stefano Morotti; Haibo Ni; Eleonora Grandi; Colleen E. Clancy; Jamie Vandenberg; Adam Hill; Mikiko Nakamura; Thomas Singer; Liudmila Polonchuk; Michelangelo Paci; Andrea Greiter‐Wilke; Ken Wang; Stephane Nave; Aaron Fullerton; Eric A. Sobie; Flora Musuamba Tshinanu; David G. Strauss

doi:10.1002/cpt.1647

General principles for the validation of proarrhythmia risk prediction models: an extension of the CiPA In Silico strategy

Zhihua Li, Gary Mirams, Takashi Yoshinaga, Bradley Ridder, Xiaomei Han, Janell E. Chen, Norman L. Stockbridge, Todd A. Wisialowski, Bruce Damiano, Stefano Severi, Pierre Morissette, Peter R. Kowey, Mark Holbrook, Godfrey Smith, Randall L. Rasmusson, Michael Liu, Zhen Song, Zhilin Qu, Derek J. Leishman, Jill Steidl‐NicholsBlanca Rodriguez, Alfonso Bueno-Orovio, Xin Zhou, Elisa Passini, Andrew G. Edwards, Stefano Morotti, Haibo Ni, Eleonora Grandi, Colleen E. Clancy, Jamie Vandenberg, Adam Hill, Mikiko Nakamura, Thomas Singer, Liudmila Polonchuk, Michelangelo Paci, Andrea Greiter‐Wilke, Ken Wang, Stephane Nave, Aaron Fullerton, Eric A. Sobie, Flora Musuamba Tshinanu, David G. Strauss

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Original language	English
Number of pages	10
Journal	CLINICAL PHARMACOLOGY AND THERAPEUTICS
DOIs	https://doi.org/10.1002/cpt.1647
Publication status	Published - 2019
Publication type	A1 Journal article-refereed

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Publication forum level 3

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10.1002/cpt.1647

Li_et_al-2019-Clinical_Pharmacology_&_TherapeuticsFinal published version, 452 KBLicence: CC BY

http://urn.fi/urn:nbn:fi:tuni-201912026470

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Li, Z., Mirams, G., Yoshinaga, T., Ridder, B., Han, X., Chen, J. E., Stockbridge, N. L., Wisialowski, T. A., Damiano, B., Severi, S., Morissette, P., Kowey, P. R., Holbrook, M., Smith, G., Rasmusson, R. L., Liu, M., Song, Z., Qu, Z., Leishman, D. J., ... Strauss, D. G. (2019). General principles for the validation of proarrhythmia risk prediction models: an extension of the CiPA In Silico strategy. CLINICAL PHARMACOLOGY AND THERAPEUTICS. https://doi.org/10.1002/cpt.1647

Li, Zhihua ; Mirams, Gary ; Yoshinaga, Takashi ; Ridder, Bradley ; Han, Xiaomei ; Chen, Janell E. ; Stockbridge, Norman L. ; Wisialowski, Todd A. ; Damiano, Bruce ; Severi, Stefano ; Morissette, Pierre ; Kowey, Peter R. ; Holbrook, Mark ; Smith, Godfrey ; Rasmusson, Randall L. ; Liu, Michael ; Song, Zhen ; Qu, Zhilin ; Leishman, Derek J. ; Steidl‐Nichols, Jill ; Rodriguez, Blanca ; Bueno-Orovio, Alfonso ; Zhou, Xin ; Passini, Elisa ; Edwards, Andrew G. ; Morotti, Stefano ; Ni, Haibo ; Grandi, Eleonora ; Clancy, Colleen E. ; Vandenberg, Jamie ; Hill, Adam ; Nakamura, Mikiko ; Singer, Thomas ; Polonchuk, Liudmila ; Paci, Michelangelo ; Greiter‐Wilke, Andrea ; Wang, Ken ; Nave, Stephane ; Fullerton, Aaron ; Sobie, Eric A. ; Tshinanu, Flora Musuamba ; Strauss, David G. / General principles for the validation of proarrhythmia risk prediction models: an extension of the CiPA In Silico strategy. In: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2019.

@article{32dbdf9be1d34d31909dcd90016ba278,

title = "General principles for the validation of proarrhythmia risk prediction models: an extension of the CiPA In Silico strategy",

author = "Zhihua Li and Gary Mirams and Takashi Yoshinaga and Bradley Ridder and Xiaomei Han and Chen, {Janell E.} and Stockbridge, {Norman L.} and Wisialowski, {Todd A.} and Bruce Damiano and Stefano Severi and Pierre Morissette and Kowey, {Peter R.} and Mark Holbrook and Godfrey Smith and Rasmusson, {Randall L.} and Michael Liu and Zhen Song and Zhilin Qu and Leishman, {Derek J.} and Jill Steidl‐Nichols and Blanca Rodriguez and Alfonso Bueno-Orovio and Xin Zhou and Elisa Passini and Edwards, {Andrew G.} and Stefano Morotti and Haibo Ni and Eleonora Grandi and Clancy, {Colleen E.} and Jamie Vandenberg and Adam Hill and Mikiko Nakamura and Thomas Singer and Liudmila Polonchuk and Michelangelo Paci and Andrea Greiter‐Wilke and Ken Wang and Stephane Nave and Aaron Fullerton and Sobie, {Eric A.} and Tshinanu, {Flora Musuamba} and Strauss, {David G.}",

note = "DUPL=50914053, Merkitty Julk0000 Virta-siirtoa varten",

year = "2019",

doi = "10.1002/cpt.1647",

language = "English",

journal = "CLINICAL PHARMACOLOGY AND THERAPEUTICS",

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Li, Z, Mirams, G, Yoshinaga, T, Ridder, B, Han, X, Chen, JE, Stockbridge, NL, Wisialowski, TA, Damiano, B, Severi, S, Morissette, P, Kowey, PR, Holbrook, M, Smith, G, Rasmusson, RL, Liu, M, Song, Z, Qu, Z, Leishman, DJ, Steidl‐Nichols, J, Rodriguez, B, Bueno-Orovio, A, Zhou, X, Passini, E, Edwards, AG, Morotti, S, Ni, H, Grandi, E, Clancy, CE, Vandenberg, J, Hill, A, Nakamura, M, Singer, T, Polonchuk, L, Paci, M, Greiter‐Wilke, A, Wang, K, Nave, S, Fullerton, A, Sobie, EA, Tshinanu, FM & Strauss, DG 2019, 'General principles for the validation of proarrhythmia risk prediction models: an extension of the CiPA In Silico strategy', CLINICAL PHARMACOLOGY AND THERAPEUTICS. https://doi.org/10.1002/cpt.1647

General principles for the validation of proarrhythmia risk prediction models: an extension of the CiPA In Silico strategy. / Li, Zhihua; Mirams, Gary; Yoshinaga, Takashi; Ridder, Bradley; Han, Xiaomei; Chen, Janell E.; Stockbridge, Norman L.; Wisialowski, Todd A.; Damiano, Bruce; Severi, Stefano; Morissette, Pierre; Kowey, Peter R.; Holbrook, Mark; Smith, Godfrey; Rasmusson, Randall L.; Liu, Michael; Song, Zhen; Qu, Zhilin; Leishman, Derek J.; Steidl‐Nichols, Jill; Rodriguez, Blanca; Bueno-Orovio, Alfonso; Zhou, Xin; Passini, Elisa; Edwards, Andrew G.; Morotti, Stefano; Ni, Haibo; Grandi, Eleonora; Clancy, Colleen E.; Vandenberg, Jamie; Hill, Adam; Nakamura, Mikiko; Singer, Thomas; Polonchuk, Liudmila; Paci, Michelangelo; Greiter‐Wilke, Andrea; Wang, Ken; Nave, Stephane; Fullerton, Aaron; Sobie, Eric A.; Tshinanu, Flora Musuamba; Strauss, David G.

In: CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2019.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - General principles for the validation of proarrhythmia risk prediction models: an extension of the CiPA In Silico strategy

AU - Li, Zhihua

AU - Mirams, Gary

AU - Yoshinaga, Takashi

AU - Ridder, Bradley

AU - Han, Xiaomei

AU - Chen, Janell E.

AU - Stockbridge, Norman L.

AU - Wisialowski, Todd A.

AU - Damiano, Bruce

AU - Severi, Stefano

AU - Morissette, Pierre

AU - Kowey, Peter R.

AU - Holbrook, Mark

AU - Smith, Godfrey

AU - Rasmusson, Randall L.

AU - Liu, Michael

AU - Song, Zhen

AU - Qu, Zhilin

AU - Leishman, Derek J.

AU - Steidl‐Nichols, Jill

AU - Rodriguez, Blanca

AU - Bueno-Orovio, Alfonso

AU - Zhou, Xin

AU - Passini, Elisa

AU - Edwards, Andrew G.

AU - Morotti, Stefano

AU - Ni, Haibo

AU - Grandi, Eleonora

AU - Clancy, Colleen E.

AU - Vandenberg, Jamie

AU - Hill, Adam

AU - Nakamura, Mikiko

AU - Singer, Thomas

AU - Polonchuk, Liudmila

AU - Paci, Michelangelo

AU - Greiter‐Wilke, Andrea

AU - Wang, Ken

AU - Nave, Stephane

AU - Fullerton, Aaron

AU - Sobie, Eric A.

AU - Tshinanu, Flora Musuamba

AU - Strauss, David G.

N1 - DUPL=50914053, Merkitty Julk0000 Virta-siirtoa varten

PY - 2019

Y1 - 2019

U2 - 10.1002/cpt.1647

DO - 10.1002/cpt.1647

M3 - Article

JO - CLINICAL PHARMACOLOGY AND THERAPEUTICS

JF - CLINICAL PHARMACOLOGY AND THERAPEUTICS

SN - 0009-9236

ER -