Abstract
Case reports describing familial clustering of eclampsia were first reported in the late 1800s, but Chesley was one of the first to perform a true genetic analysis. Chesley’s first edition text summarized his early investigations in hundreds of mother-daughter pairs. He reported that among daughters of women with eclampsia, 26% had preeclampsia in their first pregnancies. By contrast, the daughters-in-law control group had only an 8% rate of first-pregnancy preeclampsia. This comprehensively updated chapter will “fast-forward” the reader into the postgenomic era. As molecular analyses become less expensive and bioinformatic tools become more powerful, we are gaining new appreciation for the complexity of the etiologies, management strategies, and prevention of this syndrome.
Original language | English |
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Title of host publication | Chesley’s Hypertensive Disorders in Pregnancy |
Editors | Robert N. Taylor, Kirk P. Conrad, Sandra T. Davidge, Anne Catherine Staff, James M. Roberts |
Publisher | Academic Press |
Pages | 45-69 |
Number of pages | 25 |
Edition | 5th |
ISBN (Electronic) | 9780128184172 |
ISBN (Print) | 9780128184189 |
DOIs | |
Publication status | Published - 2022 |
Publication type | A3 Book chapter |
Keywords
- Complex disease
- Exome and genome sequencing
- Genetics
- Genomics
- Immunogenetics
- Polygenic
- Polymorphism
- Preeclampsia
Publication forum classification
- Publication forum level 2
ASJC Scopus subject areas
- General Medicine