Genetic Factors in the Etiology of Preeclampsia/Eclampsia

Kenneth Ward, Hannele Laivuori, Robert N. Taylor

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

1 Citation (Scopus)


Case reports describing familial clustering of eclampsia were first reported in the late 1800s, but Chesley was one of the first to perform a true genetic analysis. Chesley’s first edition text summarized his early investigations in hundreds of mother-daughter pairs. He reported that among daughters of women with eclampsia, 26% had preeclampsia in their first pregnancies. By contrast, the daughters-in-law control group had only an 8% rate of first-pregnancy preeclampsia. This comprehensively updated chapter will “fast-forward” the reader into the postgenomic era. As molecular analyses become less expensive and bioinformatic tools become more powerful, we are gaining new appreciation for the complexity of the etiologies, management strategies, and prevention of this syndrome.

Original languageEnglish
Title of host publicationChesley’s Hypertensive Disorders in Pregnancy
EditorsRobert N. Taylor, Kirk P. Conrad, Sandra T. Davidge, Anne Catherine Staff, James M. Roberts
PublisherAcademic Press
Number of pages25
ISBN (Electronic)9780128184172
ISBN (Print)9780128184189
Publication statusPublished - 2022
Publication typeA3 Book chapter


  • Complex disease
  • Exome and genome sequencing
  • Genetics
  • Genomics
  • Immunogenetics
  • Polygenic
  • Polymorphism
  • Preeclampsia

Publication forum classification

  • Publication forum level 2

ASJC Scopus subject areas

  • Medicine(all)


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