Genetic Factors in the Etiology of Preeclampsia/Eclampsia

Kenneth Ward, Hannele Laivuori, Robert N. Taylor

    Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

    5 Citations (Scopus)

    Abstract

    Case reports describing familial clustering of eclampsia were first reported in the late 1800s, but Chesley was one of the first to perform a true genetic analysis. Chesley’s first edition text summarized his early investigations in hundreds of mother-daughter pairs. He reported that among daughters of women with eclampsia, 26% had preeclampsia in their first pregnancies. By contrast, the daughters-in-law control group had only an 8% rate of first-pregnancy preeclampsia. This comprehensively updated chapter will “fast-forward” the reader into the postgenomic era. As molecular analyses become less expensive and bioinformatic tools become more powerful, we are gaining new appreciation for the complexity of the etiologies, management strategies, and prevention of this syndrome.

    Original languageEnglish
    Title of host publicationChesley’s Hypertensive Disorders in Pregnancy
    EditorsRobert N. Taylor, Kirk P. Conrad, Sandra T. Davidge, Anne Catherine Staff, James M. Roberts
    PublisherAcademic Press
    Pages45-69
    Number of pages25
    Edition5th
    ISBN (Electronic)9780128184172
    ISBN (Print)9780128184189
    DOIs
    Publication statusPublished - 2022
    Publication typeA3 Book chapter

    Keywords

    • Complex disease
    • Exome and genome sequencing
    • Genetics
    • Genomics
    • Immunogenetics
    • Polygenic
    • Polymorphism
    • Preeclampsia

    Publication forum classification

    • Publication forum level 2

    ASJC Scopus subject areas

    • General Medicine

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