Genetics of 35 blood and urine biomarkers in the UK Biobank

Nasa Sinnott-Armstrong, Yosuke Tanigawa, David Amar, Nina Mars, Christian Benner, Matthew Aguirre, Guhan Ram Venkataraman, Michael Wainberg, Hanna M. Ollila, Tuomo Kiiskinen, Aki S. Havulinna, James P. Pirruccello, Junyang Qian, Anna Shcherbina, Fatima Rodriguez, Themistocles L. Assimes, Vineeta Agarwala, Robert Tibshirani, Trevor Hastie, Samuli RipattiJonathan K. Pritchard, Mark J. Daly, Manuel A. Rivas, FinnGen, Kimmo Savinainen, Reijo Laaksonen, Jukka Peltola, Airi Jussila, Pia Isomäki, Tarja Laitinen, Hannu Kankaanranta, Mika Kähönen, Annika Auranen, Hannu Uusitalo, Hannele Uusitalo-Järvinen, Teea Salmi, Harri Siirtola, Javier Gracia Tabuenca

Research output: Contribution to journalArticleScientificpeer-review

5 Citations (Scopus)

Abstract

Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n = 363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations and additional sets of large-effect (>0.1 s.d.) protein-altering, human leukocyte antigen (HLA) and copy number variant (CNV) associations. Through Mendelian randomization (MR) analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores (PRSs) for each biomarker and build ‘multi-PRS’ models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout and alcoholic cirrhosis genetic risk stratification in an independent dataset (FinnGen; n = 135,500) relative to single-disease PRSs. Together, our results delineate the genetic basis of biomarkers and their causal influences on diseases and improve genetic risk stratification for common diseases.

Original languageEnglish
Pages (from-to)185-194
Number of pages10
JournalNature Genetics
Volume53
Issue number2
DOIs
Publication statusPublished - 2021
Publication typeA1 Journal article-refereed

Publication forum classification

  • Publication forum level 3

ASJC Scopus subject areas

  • Genetics

Fingerprint

Dive into the research topics of 'Genetics of 35 blood and urine biomarkers in the UK Biobank'. Together they form a unique fingerprint.

Cite this