Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

S. Ligthart; A. Vaez; U. Võsa; M.G. Stathopoulou; P.S. de Vries; B.P. Prins; P.J. Van der Most; T. Tanaka; E. Naderi; L.M. Rose; Y. Wu; R. Karlsson; M. Barbalic; H. Lin; R. Pool; G. Zhu; A. Macé; C. Sidore; S. Trompet; M. Mangino; M. Sabater-Lleal; J.P. Kemp; A. Abbasi; T. Kacprowski; N. Verweij; A.V. Smith; T. Huang; C. Marzi; M.F. Feitosa; K.K. Lohman; M.E. Kleber; Y. Milaneschi; C. Mueller; M. Huq; E. Vlachopoulou; Leo-Pekka Lyytikäinen; C. Oldmeadow; J. Deelen; M. Perola; J.H. Zhao; B. Feenstra; B.Z. Alizadeh; H.M. Boezen; L. Franke; P van der Harst; Mika Kähönen; Terho Lehtimäki

doi:10.1016/j.ajhg.2018.09.009

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

S. Ligthart
, A. Vaez
, U. Võsa
, M.G. Stathopoulou
, P.S. de Vries
, B.P. Prins
, P.J. Van der Most
, T. Tanaka
, E. Naderi
, L.M. Rose
, Y. Wu
, R. Karlsson
, M. Barbalic
, H. Lin
, R. Pool
, G. Zhu
, A. Macé
, C. Sidore
, S. Trompet
, M. Mangino

M. Sabater-Lleal, J.P. Kemp, A. Abbasi, T. Kacprowski, N. Verweij, A.V. Smith, T. Huang, C. Marzi, M.F. Feitosa, K.K. Lohman, M.E. Kleber, Y. Milaneschi, C. Mueller, M. Huq, E. Vlachopoulou, Leo-Pekka Lyytikäinen, C. Oldmeadow, J. Deelen, M. Perola, J.H. Zhao, B. Feenstra, B.Z. Alizadeh, H.M. Boezen, L. Franke, P van der Harst, Mika Kähönen, Terho Lehtimäki

Department of Clinical Chemistry

Research output: Contribution to journal › Article › Scientific › peer-review

327 Citations (Scopus)

Original language	English
Pages (from-to)	691-706
Journal	American Journal of Human Genetics
Volume	103
Issue number	5
DOIs	https://doi.org/10.1016/j.ajhg.2018.09.009
Publication status	Published - 2018
Publication type	A1 Journal article-refereed

Keywords

C-reactive protein
DEPICT
Mendelian randomization
coronary artery disease
genome-wide association study
inflammation
inflammatory disorders
schizophrenia
system biology

Publication forum classification

Publication forum level 3

Access to Document

10.1016/j.ajhg.2018.09.009

Cite this

Ligthart, S., Vaez, A., Võsa, U., Stathopoulou, M. G., de Vries, P. S., Prins, B. P., Van der Most, P. J., Tanaka, T., Naderi, E., Rose, L. M., Wu, Y., Karlsson, R., Barbalic, M., Lin, H., Pool, R., Zhu, G., Macé, A., Sidore, C., Trompet, S., ... Lehtimäki, T. (2018). Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. American Journal of Human Genetics, 103(5), 691-706. https://doi.org/10.1016/j.ajhg.2018.09.009

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title = "Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders",

keywords = "C-reactive protein, DEPICT, Mendelian randomization, coronary artery disease, genome-wide association study, inflammation, inflammatory disorders, schizophrenia, system biology, C-reactive protein, DEPICT, Mendelian randomization, coronary artery disease, genome-wide association study, inflammation, inflammatory disorders, schizophrenia, system biology",

author = "S. Ligthart and A. Vaez and U. V{\~o}sa and M.G. Stathopoulou and \{de Vries\}, P.S. and B.P. Prins and \{Van der Most\}, P.J. and T. Tanaka and E. Naderi and L.M. Rose and Y. Wu and R. Karlsson and M. Barbalic and H. Lin and R. Pool and G. Zhu and A. Mac{\'e} and C. Sidore and S. Trompet and M. Mangino and M. Sabater-Lleal and J.P. Kemp and A. Abbasi and T. Kacprowski and N. Verweij and A.V. Smith and T. Huang and C. Marzi and M.F. Feitosa and K.K. Lohman and M.E. Kleber and Y. Milaneschi and C. Mueller and M. Huq and E. Vlachopoulou and Leo-Pekka Lyytik{\"a}inen and C. Oldmeadow and J. Deelen and M. Perola and J.H. Zhao and B. Feenstra and B.Z. Alizadeh and H.M. Boezen and L. Franke and \{van der Harst\}, P and Mika K{\"a}h{\"o}nen and Terho Lehtim{\"a}ki",

year = "2018",

doi = "10.1016/j.ajhg.2018.09.009",

language = "English",

volume = "103",

pages = "691--706",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "5",

}

Ligthart, S, Vaez, A, Võsa, U, Stathopoulou, MG, de Vries, PS, Prins, BP, Van der Most, PJ, Tanaka, T, Naderi, E, Rose, LM, Wu, Y, Karlsson, R, Barbalic, M, Lin, H, Pool, R, Zhu, G, Macé, A, Sidore, C, Trompet, S, Mangino, M, Sabater-Lleal, M, Kemp, JP, Abbasi, A, Kacprowski, T, Verweij, N, Smith, AV, Huang, T, Marzi, C, Feitosa, MF, Lohman, KK, Kleber, ME, Milaneschi, Y, Mueller, C, Huq, M, Vlachopoulou, E, Lyytikäinen, L-P, Oldmeadow, C, Deelen, J, Perola, M, Zhao, JH, Feenstra, B, Alizadeh, BZ, Boezen, HM, Franke, L, van der Harst, P, Kähönen, M & Lehtimäki, T 2018, 'Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders', American Journal of Human Genetics, vol. 103, no. 5, pp. 691-706. https://doi.org/10.1016/j.ajhg.2018.09.009

TY - JOUR

T1 - Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

AU - Ligthart, S.

AU - Vaez, A.

AU - Võsa, U.

AU - Stathopoulou, M.G.

AU - de Vries, P.S.

AU - Prins, B.P.

AU - Van der Most, P.J.

AU - Tanaka, T.

AU - Naderi, E.

AU - Rose, L.M.

AU - Wu, Y.

AU - Karlsson, R.

AU - Barbalic, M.

AU - Lin, H.

AU - Pool, R.

AU - Zhu, G.

AU - Macé, A.

AU - Sidore, C.

AU - Trompet, S.

AU - Mangino, M.

AU - Sabater-Lleal, M.

AU - Kemp, J.P.

AU - Abbasi, A.

AU - Kacprowski, T.

AU - Verweij, N.

AU - Smith, A.V.

AU - Huang, T.

AU - Marzi, C.

AU - Feitosa, M.F.

AU - Lohman, K.K.

AU - Kleber, M.E.

AU - Milaneschi, Y.

AU - Mueller, C.

AU - Huq, M.

AU - Vlachopoulou, E.

AU - Lyytikäinen, Leo-Pekka

AU - Oldmeadow, C.

AU - Deelen, J.

AU - Perola, M.

AU - Zhao, J.H.

AU - Feenstra, B.

AU - Alizadeh, B.Z.

AU - Boezen, H.M.

AU - Franke, L.

AU - van der Harst, P

AU - Kähönen, Mika

AU - Lehtimäki, Terho

PY - 2018

Y1 - 2018

KW - C-reactive protein

KW - DEPICT

KW - Mendelian randomization

KW - coronary artery disease

KW - genome-wide association study

KW - inflammation

KW - inflammatory disorders

KW - schizophrenia

KW - system biology

KW - C-reactive protein

KW - DEPICT

KW - Mendelian randomization

KW - coronary artery disease

KW - genome-wide association study

KW - inflammation

KW - inflammatory disorders

KW - schizophrenia

KW - system biology

U2 - 10.1016/j.ajhg.2018.09.009

DO - 10.1016/j.ajhg.2018.09.009

M3 - Article

SN - 0002-9297

VL - 103

SP - 691

EP - 706

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 5

ER -