Growth of immobilized DNA by polymerase: Bridging nanoelectrodes with individual dsDNA molecules

Veikko Linko, Jenni Leppiniemi, Boxuan Shen, Einari Niskanen, Vesa P. Hytönen, J. Jussi Toppari

    Research output: Contribution to journalArticleScientificpeer-review

    4 Citations (Scopus)

    Abstract

    We present a method for controlled connection of gold electrodes with dsDNA molecules (locally on a chip) by utilizing polymerase to elongate single-stranded DNA primers attached to the electrodes. Thiol-modified oligonucleotides are directed and immobilized to nanoscale electrodes by means of dielectrophoretic trapping, and extended in a procedure mimicking PCR, finally forming a complete dsDNA molecule bridging the gap between the electrodes. The technique opens up opportunities for building from the bottom-up, for detection and sensing applications, and also for molecular electronics.

    Original languageEnglish
    Pages (from-to)3788-3792
    Number of pages5
    JournalNanoscale
    Volume3
    Issue number9
    DOIs
    Publication statusPublished - 2011
    Publication typeA1 Journal article-refereed

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