Guanidinium cations pair with positively charged arginine side chains in water

Anna Kubíčková; Tomáš Křížek; Pavel Coufal; Erik Wernersson; Jan Heyda; Pavel Jungwirth

doi:10.1021/jz2005495

Guanidinium cations pair with positively charged arginine side chains in water

Anna Kubíčková, Tomáš Křížek, Pavel Coufal, Erik Wernersson, Jan Heyda, Pavel Jungwirth

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Using capillary electrophoresis and molecular dynamics simulations, we directly demonstrate that guanidinium cations exhibit an affinity for the positively charged side chains of arginine-containing peptides in aqueous solutions, while no such effect is observed for sodium cations and/or lysine. Such a counterintuitive pairing between these two positively charged moieties has implications for destabilization and aggregation of arginine-rich proteins in guanidinium salt solutions.

Original language	English
Pages (from-to)	1387-1389
Number of pages	3
Journal	Journal of Physical Chemistry Letters
Volume	2
Issue number	12
DOIs	https://doi.org/10.1021/jz2005495
Publication status	Published - 16 Jun 2011
Publication type	A1 Journal article-refereed

ASJC Scopus subject areas

General Materials Science

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10.1021/jz2005495

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abstract = "Using capillary electrophoresis and molecular dynamics simulations, we directly demonstrate that guanidinium cations exhibit an affinity for the positively charged side chains of arginine-containing peptides in aqueous solutions, while no such effect is observed for sodium cations and/or lysine. Such a counterintuitive pairing between these two positively charged moieties has implications for destabilization and aggregation of arginine-rich proteins in guanidinium salt solutions.",

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AU - Kubíčková, Anna

AU - Křížek, Tomáš

AU - Coufal, Pavel

AU - Wernersson, Erik

AU - Heyda, Jan

AU - Jungwirth, Pavel

PY - 2011/6/16

Y1 - 2011/6/16

N2 - Using capillary electrophoresis and molecular dynamics simulations, we directly demonstrate that guanidinium cations exhibit an affinity for the positively charged side chains of arginine-containing peptides in aqueous solutions, while no such effect is observed for sodium cations and/or lysine. Such a counterintuitive pairing between these two positively charged moieties has implications for destabilization and aggregation of arginine-rich proteins in guanidinium salt solutions.

AB - Using capillary electrophoresis and molecular dynamics simulations, we directly demonstrate that guanidinium cations exhibit an affinity for the positively charged side chains of arginine-containing peptides in aqueous solutions, while no such effect is observed for sodium cations and/or lysine. Such a counterintuitive pairing between these two positively charged moieties has implications for destabilization and aggregation of arginine-rich proteins in guanidinium salt solutions.

UR - https://www.scopus.com/pages/publications/79959413305

U2 - 10.1021/jz2005495

DO - 10.1021/jz2005495

M3 - Article

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EP - 1389

JO - Journal of Physical Chemistry Letters

JF - Journal of Physical Chemistry Letters

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ER -

Guanidinium cations pair with positively charged arginine side chains in water

Abstract

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