Gut-on-chip devices as intestinal inflammation models and their future for studying multifactorial diseases

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Inflammatory bowel disease (IBD), celiac disease, and other inflammatory conditions of the gastrointestinal tract are highly prevalent in society. Due to the complexity of factors involved, detailed pathogenesis is difficult to determine and thus remains elusive in many cases. The advent of gut-on-chip devices has permitted more accurate modeling of the gut microenvironment with the inclusion of fluid flow and mechanical cues that are true to intestinal architecture and physiology. This review outlines the evolution of gut-on-chip platforms towards greater physiological relevance and elucidates how these devices have been used to model and study intestinal inflammation in humans. In addition, we identify key elements from both technological and disease standpoints that are integral for accurate gut-on-chip models of IBD and celiac disease.
Original languageEnglish
Number of pages13
JournalFrontiers in Lab on a Chip Technologies
Volume2
DOIs
Publication statusPublished - 11 Jan 2024
Publication typeA1 Journal article-refereed

Keywords

  • Gut-On-Chip
  • inflammatory bowel disease
  • celiac disease
  • IBD

Publication forum classification

  • Publication forum level 0

ASJC Scopus subject areas

  • General Health Professions
  • General Engineering
  • General Materials Science
  • General Biochemistry,Genetics and Molecular Biology

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